Dermal Cell News Volume 7.25 | Jul 12 2021

    By
    Justin.choi
    -
    0
    54







    2021-07-12 | DCN 7.25


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.25 – 12 July, 2021
    TOP STORY

    NNT Mediates Redox-Dependent Pigmentation via a UVB- and MITF-Independent Mechanism

    Researchers described an ultraviolet (UV)- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation.
    [Cell]

    AbstractGraphical Abstract

    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Niche Stiffening Compromises Hair Follicle Stem Cell Potential during Ageing by Reducing Bivalent Promoter Accessibility

    Investigators addressed the mechanisms of aging in murine hair follicle stem cells (HFSCs) and observed a widespread reduction in chromatin accessibility in aged HFSCs, particularly at key self-renewal and differentiation genes, characterized by bivalent promoters occupied by active and repressive chromatin marks.
    [Nature Cell Biology]

    Abstract

    Alginate/Chitosan-Based Hydrogel Loaded with Gene Vectors to Deliver Polydeoxyribonucleotide for Effective Wound Healing

    Scientists released gene carrier, polydeoxyribonucleotide (PDRN)-loaded CaCO3 nanoparticle, to be effectively taken up by skin fibroblasts. Under the action of PDRN, the wound healing rate was confirmed to be significantly accelerated.
    [Biomaterials Science]

    Abstract

    Resveratrol Promotes Skin Wound Healing by Regulating the miR-212/CASP8 Axis

    Human epidermal keratinocyte cells were treated with lipopolysaccharide, and a mouse skin wound-healing model was established.
    [Laboratory Investigation]

    Abstract

    GJB5 Association with BRAF Mutation and Survival in Cutaneous Malignant Melanoma

    Researchers investigated Connexin 31.1 (GJB5) expression and identified any association with BRAF mutational status, melanoma patient prognosis and MAPK inhibitors treatment.
    [British Journal of Dermatology]

    Abstract

    STAT3-Induced ZBED3-AS1 Promotes the Malignant Phenotypes of Melanoma Cells by Activating PI3K/AKT Signaling Pathway

    Investigators discovered that ZBED3 antisense RNA 1 (ZBED3-AS1) was overexpressed in melanoma cells compared with human epidermal melanocytes.
    [RNA Biology]

    Abstract

    NCK1-AS1 Promotes the Progression of Melanoma by Accelerating Cell Proliferation and Migration via Targeting miR-526b-5p/ADAM15 Axis

    NCK1-antisense 1 (NCK1-AS1) was overexpressed in melanoma cell lines and NCK1-AS1 knockdown hampered the proliferation and migration of melanoma cells.
    [Cancer Cell International]

    Full Article

    MicroRNA-378a-3p Is Overexpressed in Psoriasis and Modulates Cell Cycle Arrest in Keratinocytes via Targeting BMP2 Gene

    Scientists reported a significant up-regulation of miR-378a-3p in skin biopsies from active psoriatic lesions while it was down-regulated after treatment with methotrexate or narrow-band ultraviolet B phototherapy.
    [Scientific Reports]

    Full Article

    Delineating Papillary Dermis around Basal Cell Carcinomas by High and Ultrahigh Resolution Optical Coherence Tomography – a Pilot Study

    Scientists investigated the delicate signal of papillary dermis using an in-house developed ultrahigh resolution coherence tomography (OCT) system with shadow compensation and a commercial multi-focus high resolution OCT system for clinical basal cell carcinoma imaging.
    [Journal of Biophotonics]

    Abstract

    Explore virtual support and resources to stay productive and connected with your field.
    REVIEWS

    Hair Follicle Stem Cells for Tissue Regeneration

    The authors discuss the various stem cell types identified in rodent and human hair follicles and ongoing studies on the potential use of hair follicle stem cells for skin, bone, cardio-vascular, and nerve tissue engineering.
    [Tissue Engineering Part B-Reviews]

    Abstract

    The Extracellular Matrix in Skin Inflammation and Infection

    Researchers review the composition, structure and function of the extracellular matrix in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Approves Pembrolizumab for Locally Advanced Cutaneous Squamous Cell Carcinoma

    The FDA has expanded the label for pembrolizumab for use as a monotherapy in the treatment of patients with locally advanced cutaneous squamous cell carcinoma that was not curable by surgery or radiation.
    [OncLive, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Tumorigenesis in Melanoma and Glioblastoma

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Fellow – Nanocellulose Electrodes

    KTH Royal Institute of Technology – Stockholm, Sweden

    Professorship – Immunodermatology

    University of Erlangen-Nuremberg – Erlangen, Germany

    Postdoctoral Fellow – In-Situ Gene Therapy

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Immunology or Bacteriology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    Brought to you by