Dermal cell News Volume 7.26 | Jul 19 2021

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    2021-07-19 | DCN 7.26


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.26 – 19 July, 2021
    TOP STORY

    Myofibroblast Transcriptome Indicates SFRP2hi Fibroblast Progenitors in Systemic Sclerosis Skin

    Researchers showed that systemic sclerosis skin dermal myofibroblasts arose in two steps from an SFRP2hi/DPP4-expressing progenitor fibroblast population.
    [Nature Communications]

    Full Article

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Cyclic Growth of Dermal Papilla and Regeneration of Follicular Mesenchymal Components during Feather Cycling

    Scientists studied how dermal components of feather follicles undergo physiological and plucking injury-induced regeneration.
    [Development]

    Abstract

    Metformin-Induced ROS Upregulation as Amplified by Apigenin Causes Profound Anticancer Activity While Sparing Normal Cells

    Metformin combined with apigenin increased ROS levels dramatically and decreased cell viability in various cancer cells including AsPC-1 cells, with each drug used singly having a minimal effect.
    [Scientific Reports]

    Full Article

    Growth Arrest and DNA Damage-Inducible Proteins (GADD45) in Psoriasis

    Researchers analyzed the expression of GADD45a and GADD45b in the skin, dendritic cells and circulating T cells in a cohort of psoriasis patients and their regulation by inflammatory signals.
    [Scientific Reports]

    Full Article

    Development of a Novel Nanoemulgel Formulation Containing Cumin Essential Oil as Skin Permeation Enhancer

    Scientists explored the transdermal permeation enhancing capability of cumin essential oil in nanoemulgel systems containing diclofenac sodium.
    [Drug Delivery and Translational Research]

    Full Article

    PERK Mediates Resistance to BRAF Inhibition in Melanoma with Impaired PTEN

    Investigators showed that PERK played a critical role in BRAF inhibitor-acquired resistance in melanoma with impaired PTEN.
    [npj Precision Oncology]

    Full Article

    The Landscape of Driver Mutations in Cutaneous Squamous Cell Carcinoma

    Researchers provided a catalog of driver genes in cutaneous squamous cell carcinoma, offering points of therapeutic intervention and insights into the biology of cutaneous squamous cell carcinoma.
    [NPJ Genomic Medicine]

    Full Article

    A Secondary Role for Hypoxia and HIF1 in the Regulation of (IFNγ-Induced) PD-L1 Expression in Melanoma

    Investigators explored the hypoxic regulation of programmed death ligand 1 (PD-L1) expression in human melanoma, and its interaction with IFNγ-induced PD-L1 expression.
    [Cancer Immunology Immunotherapy]

    Full Article

    The BRD4 Inhibitor JQ1 Promotes Melanoma Cell Apoptosis by Regulating Mitochondrial Dynamics

    Scientists showed that the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 promoted the apoptosis of B16 melanoma cells by altering mitochondrial dynamics, thereby inducing mitochondrial dysfunction and increasing oxidative stress.
    [Cancer Science]

    Full Article

    Resources for Your T Cell Therapy Research
    REVIEWS

    Cannabinoids and Their Derivatives in Struggle against Melanoma

    The authors summarize recent advances in studies on cannabinoids used in the setting of melanoma treatment.
    [Pharmacological Reports]

    Full Article| Graphical Abstract

    INDUSTRY AND POLICY NEWS

    Lilly and Incyte Provide Update on Supplemental New Drug Application for Baricitinib for the Treatment of Moderate to Severe Atopic Dermatitis

    Eli Lilly and Company and Incyte announced that the US FDA will not meet the Prescription Drug User Fee Act action date for the supplemental new drug application for baricitinib for the treatment of adults with moderate to severe atopic dermatitis.
    [Eli Lilly and Company, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Principal/Senior Bioinformatician – Rare Skin Tumor

    Wellcome Trust Sanger Institute – Cambridge, United Kingdom

    Postdoctoral Researcher – Tumorigenesis in Melanoma and Glioblastoma

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Fellow – Nanocellulose Electrodes

    KTH Royal Institute of Technology – Stockholm, Sweden

    Professorship – Immunodermatology

    University of Erlangen-Nuremberg – Erlangen, Germany

    Postdoctoral Fellow – Immunology or Bacteriology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

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