 | | Vol. 7.27 – 26 July, 2021 |
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| The authors evaluated the effects of cannabidiol, a phytocannabinoid known for its antioxidant and anti-inflammatory properties, on the proteome of keratinocyte membranes exposed to hydrogen peroxide.
[Redox Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Severe injuries to skin including hypodermis require full-thickness skin replacement. Investigators bio-engineered a tri-layered human skin substitute containing the epidermis, dermis, and hypodermis.
[Acta Biomaterialia] |
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| Researchers showed that Ly6G deficiency decreased the initial infection rate of neutrophils recruited to the site of skin infection.
[Scientific Reports] |
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| Scientists showed that treatment with burn serum could significantly upregulated the phosphorylation level of extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase and the expression of cleaved caspase-3 and downregulated the expression of Bcl2 when compared with those in negative control of small interfering RNA transfected H9C2 cells
[Cell Biochemistry and Biophysics] |
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| Researchers investigated the effect of the 3D-fibroblast dermis on the expression of tight junction (TJ)-related proteins and TJ function in layer-by-layer-3D Skin.
[ACS Biomaterials Science & Engineering] |
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| In vitro experiments showed that a subset of combination therapy melanoma cells was sensitive to mTORC1 inhibition.
[Oncogene] |
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| The authors showed that dedifferentiation of melanocytic-type melanoma cells into mesenchymal-like cells and acquisition of tolerance to targeted therapies was achieved through chronic inhibition of CDK7.
[EMBO Reports] |
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| SIRT7 has evoked an interest in the study of hair follicle stem cells, but its role in melanin synthesis remains unclear. Investigators developed SIRT7 gene knock out melanoma cells using the CRISPR/Cas9 system.
[Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease] |
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| Researchers investigated combined effects of cold atmospheric plasma and the chemotherapeutic drug doxorubicin on murine and human melanoma cells, and normal cells.
[Scientific Reports] |
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| Scientists revealed that TβRI‑TβRII‑Fc chimeric receptor suppressed the epithelial‑mesenchymal transition program in melanoma cells in vitro induced by any of the three TGF‑β isoforms, as revealed by decreased expression of mesenchymal markers.
[Oncology Reports] |
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| Increased autoantigen presentation by HLA molecules, cross-activation of pathogen-induced T cells against autologous structures, altered metabolism of self-proteins, and excessive production of proinflammatory signals may all contribute to the breakdown of immune tolerance and the development of autoimmune skin diseases.
[Journal of Investigative Dermatology] |
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| PolarityTE, Inc. announced the submission of an investigational new drug application to the US FDA seeking authorization to commence a clinical trial to evaluate its SkinTE® product for the proposed indication of treatment of chronic cutaneous ulcers.
[PolarityTE, Inc.] |
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| September 5 – 8, 2021
Exeter, England, United Kingdom |
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| | CRUK Manchester Institute – Manchester, England, United Kingdom |
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| | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| KTH Royal Institute of Technology – Stockholm, Sweden |
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| University of Erlangen-Nuremberg – Erlangen, Germany |
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