Dermal Cell News Volume 7.30 | Aug 23 2021

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    Justin.choi
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    2021-08-23 | DCN 7.30


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.30 – 23 August, 2021
    TOP STORY

    Epigenetic Control of Melanoma Cell Invasiveness by the Stem Cell Factor SALL4

    Transcriptional profiling and in vitro assays using human melanoma cells demonstrated that SALL4 loss induced a phenotype switch and the acquisition of an invasive phenotype.
    [Nature Communications]

    Full Article

    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Biofabrication of Skin Tissue Constructs Using Alginate, Gelatin and Diethylaminoethyl Cellulose Bioink

    Researchers presented alginate, gelatin and diethylaminoethyl cellulose based bioink formulation and its application in bioprinting and biofabrication of skin tissue equivalents.
    [International Journal of Biological Macromolecules]

    AbstractGraphical Abstract

    Tandem Mass Spectrometry of Aqueous Extract from Ficus dubia Sap and Its Cell-Based Assessments for Use as a Skin Antioxidant

    Scientists investigated the chemical components of the Ficus dubia sap extracted by liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry and its potential use in cosmetics in terms of cellular antioxidation on keratinocytes, phototoxicity, and irritation on 3D skin cell models.
    [Scientific Reports]

    Full Article

    E-Cigarette Fluids and Aerosol Residues Cause Oxidative Stress and an Inflammatory Response in Human Keratinocytes and 3D Skin Models

    Investigators evaluated the effects of electronic cigarette (EC) refill fluids and EC exhaled aerosol residue on cultured human keratinocytes and MatTek EpiDerm™, a 3D air liquid interface human skin model.
    [Toxicology in Vitro]

    Abstract

    Characterizing DNA Methylation Signatures and Their Potential Functional Roles in Merkel Cell Carcinoma

    Scientists conducted global DNA methylation profiling of clinically annotated merkel cell carcinoma (MCC) primary tumors, metastatic skin tumors, metastatic lymph node tumors, paired normal tissues, and two human MCC cell lines using the Illumina Infinium EPIC DNA methylation BeadArray platform.
    [Genome Medicine]

    Full Article

    hnRNP-A1 Binds to the IRES of MELOE-1 Antigen to Promote Its Translation in Stressed Melanoma Cells

    Researchers explored the translation control of melanoma-overexpressed antigen 1 (MELOE-1) and provided evidence that heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) bound to the MELOE-1 internal ribosomal entry sequence (IRES) and acted as an IRES trans-activating factor to promote the translation of MELOE-1 in melanoma cells.
    [Molecular Oncology]

    Abstract

    Inhibition of Spindle and Kinetochore Associated Complex Subunit 3 Suppresses the Proliferation and Invasion and Induced the Apoptosis of Cutaneous Melanoma by Affecting the PI3K/Akt Pathway

    Scientists evaluated the possible role of SKA3 in cutaneous melanoma (CM). A high SKA3 level was found in CM tissues and predicted a poor prognosis.
    [Journal of Biochemical and Molecular Toxicology]

    Abstract

    Nanoliposomes Co-Encapsulating Ce6 and SB3CT against the Proliferation and Metastasis of Melanoma with the Integration of Photodynamic Therapy and NKG2D-Related Immunotherapy on A375 Cells

    Researchers designed a nanoliposome co-encapsulation of chlorin E6 (Ce6) and SB-3CT to realize significant antitumoral proliferation and metastasis efficacy after laser irradiation in A375 cells.
    [Nanotechnology]

    AbstractFull Article

    Particulate Matter-Induced Atmospheric Skin Aging Is Aggravated by UVA and Inhibited by a Topical L-Ascorbic Acid Compound

    Scientists analyzed whether ultraviolet A aggravated the particulate matter-induced inflammatory cascade, which contributed to the aging of skin-derived cells.
    [Photodermatology Photoimmunology & Photomedicine]

    Abstract

    Free Wallchart: Dynamic Modeling in Organoids
    REVIEWS

    3D Bioprinting Constructs to Facilitate Skin Regeneration

    The authors summarize bioink formulations, cell combinations, as well as manufacturing methods exploited to develop 3D bioprinted constructs for skin regeneration.
    [Advanced Functional Materials]

    Abstract

    Non-Coding RNA Dysregulation in Skin Cancers

    Scientists summarize the functional role of non-coding RNAs in skin cancers and their potential clinical application as biomarkers.
    [Essays in Biochemistry]

    Abstract

    INDUSTRY AND POLICY NEWS

    Kezar Life Sciences Announces Completion of Enrollment of Its Phase II PRESIDIO Clinical Trial of KZR-616 in Polymyositis and Dermatomyositis

    Kezar Life Sciences, Inc. announced that PRESIDIO, its Phase II clinical trial to evaluate the safety and efficacy of KZR-616 for the treatment of polymyositis and dermatomyositis completed the target enrollment of 24 subjects.
    [Kezar Life Sciences, Inc.]

    Press Release

    FEATURED EVENT

    Lymphocyte Antigen Receptor Signaling

    May 28 – June 1, 2022
    Castelnuovo Berardenga, Siena, Italy

    > See All Events

    JOB OPPORTUNITIES

    PhD position – Integrated Skin Transcriptomics

    University Medical Center Schleswig-Holstein – Kiel, Germany

    Postdoctoral Researcher – Skin Organoid

    University of California Irvine – Irvine, California, United States

    Research Assistant – Pharmacology

    The Scripps Research Institute – La Jolla, California, United States

    Postdocotral Fellow – Liquid Chromatography-Mass Spectrometry

    Buck Institute for Research on Aging – Novato, California, United States

    Postdoctoral Fellow – Cancer Genomics and Liquid Biopsies

    University of Gothenburg – Gothenburg, Sweden

    > See All Jobs

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