 | | Vol. 7.31 – 30 August, 2021 |
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| Investigators analyzed the gene expression profile of STING and related downstream targets in the skin samples of healthy people and psoriasis patients from GEO database. Cellular inhibitory activity of H-151 on STING pathway was confirmed via qPCR and western blotting.
[British Journal of Pharmacology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers, activation markers, differentiation markers, apoptosis factors, and proliferation/differentiation regulators was investigated to compared with that of those in keratinocytes derived from normal skin tissue.
[Scientific Reports] |
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| Scientists investigated the relationship between melanin production and lipofuscin synthesis in normal mouse melanoma cell line B16F1 cells and Tyrosinase gene knockout cells.
[Life Sciences] |
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| Test compounds were applied to the ears of female BALB/c mice daily for three days in a primary irritancy/local lymph node assay. Sensitization was assessed in vitro in the direct peptide reactivity assay, KeratinoSens™ assay, and human cell line activation test.
[Journal of Applied Toxicology] |
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| Prolonged skin exposure to ultraviolet radiation can lead to development of several acute and chronic diseases, with UVA exposure considered a primary cause of dermal photodamage. Researchers prepared a wild ginseng adventitious root extract that could alleviate UVA irradiation-induced NIH-3T3 cell viability decline.
[Wound Repair and Regeneration] |
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| Quantitative real-time PCR analysis was carried out to detect the RNA expression of IGF2BP3 in the A375 cell line, melanoma tissues, and normal tissues.
[Cancer Cell International] |
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| Psoriatic HaCat cells were used to investigate the function of NEAT1 and Galectin-7 as well as the effect and mechanism of paeoniflorin in psoriasis.
[Anti-Cancer Drugs] |
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| Dermal mesenchymal stem cells were cocultured with primary keratinocytes either from psoriatic lesions or from normal subjects using Transwell plate. Expression levels of proteins were analyzed by Western blotting.
[International Journal of Dermatology] |
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| The expression of three-hydroxy-3-methylglutaryl coenzyme A synthase 1 in cultured keratinocytes was up-regulated by exogenous Gal-7 and down-regulated in Gal-7 siRNA transfected cells.
[Journal of Investigative Dermatology] |
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| The therapeutic landscape for non-melanoma skin cancer has recently expanded with the development of effective and targeted immunotherapy. The authors provide an overview of the role of immunotherapy in the management of advanced cutaneous carcinomas.
[Current Oncology Reports] |
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| Scientists Dr. Cristina Puig-Saus and Dr. Daniel Shin from the UCLA Jonsson Comprehensive Cancer Center have received a $1 million Translational Research Award from the US Department of Defense Melanoma Research Program to help advance the use of chimeric antigen receptor, or CAR, T cell therapy as a treatment for people with acral, mucosal and uveal melanomas.
[News-Medical.Net] |
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| Castle Biosciences, Inc. announced that it has been awarded a five-year US Federal Supply Schedule contract from the Veterans Health Administration for its DecisionDx®-Melanoma gene expression profile test.
[Castle Biosciences, Inc] |
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| June 5 – 10, 2022
Ventura, California, United States |
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| University of Colorado – Aurora, Colorado, United States |
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| University Medical Center Schleswig-Holstein – Kiel, Germany |
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| University of California Irvine – Irvine, California, United States |
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| | The Scripps Research Institute – La Jolla, California, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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