| Vol. 7.32 – 13 September, 2021 |
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| During development, neural crest cells give rise to melanoblasts, which then further differentiate into melanocytes. Using a combination of zebrafish transgenesis and human pluripotent stem cell models, researchers assessed oncogenic response to BRAFV600E in each of these three cell states. [Science] |
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PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| Scientists used a hypertrophic scarring mouse model in which Jun was overexpressed globally or specifically in α-smooth muscle or collagen type I–expressing cells to cause excessive extracellular matrix deposition by skin fibroblasts in the skin after wounding. [Science Translational Medicine] |
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| Researchers reported that both human amniotic stem cells and their conditional medium had a potent anti-hyperpigmentation in skin in vivo and in vitro. [Stem Cell Research & Therapy] |
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| Scientists examined if blocking aquaporin 3 could interfere arsenic-induced autophagy in keratinocytes. Expression of aquaporin 3 was increased in arsenical cancers and in arsenic-treated keratinocytes. [Scientific Reports] |
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| Investigators found out how the conditioned medium of adipose-derived stem cells exerted an anti-fibrotic effect in keloid dermis-derived fibroblasts. [Burns & Trauma] |
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| Scientists hypothesized that Felis catus papillomavirus was involved in the development of merkel cell carcinoma in cats, similar to Squamous cell carcinoma and basal cell carcinoma. [Veterinary Pathology] |
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| In vitro studies showed that the herbal formula stimulated cell proliferation of both dermal papilla and HaCaT cells and increased the phosphorylated form of the extracellular signal-regulated kinase 1 and 2, a well-known marker for cell proliferation. [Heliyon] |
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| | Researchers used a single-cell enrichment and RNA-sequencing pipeline to study human epidermal melanocytes directly from the skin, capturing transcriptomes across different anatomical sites, developmental age, sexes and multiple skin tones. [Nature Cell Biology] |
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| Scientists showed that methyltransferase-like 14 (METTL14) , a critical component of the N6-methyladenosine (m6A) RNA methyltransferase complex, promoted global genome repair through regulating m6A mRNA methylation–mediated DDB2 translation and suppressed ultraviolet B radiation-induced skin tumorigenesis. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Using micro-fabricated channels, researchers demonstrated that metastatic, A375-M2, melanoma cells adopted features of both mesenchymal and bleb-based migration. [Scientific Reports] |
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| Scientists evaluated the effects of noncytotoxic doses of irinotecan or its active metabolite SN38 on collagen production in systemic sclerosis fibroblasts. [Scientific Reports] |
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| Researchers hypothesized that loss of miR-1469 expression in melanoma contributed to altered tumor cell functions mediating disease progression. [PLoS One] |
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| In case of skin, accumulation of senescence in all major compartments with aging is well documented and might be responsible for most, if not all, the molecular changes observed during aging. Incorporation of senescent cells into in vitro skin models recapitulates changes typically associated with skin aging. [Ageing Research Reviews] |
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| Psoriasis is known to alter the expression of proteins that are involved in the inflammatory and antioxidant response, as well as protein biosynthesis, degradation, as well as cell proliferation and apoptosis. [Journal of Pharmaceutical and Biomedical Analysis] |
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| Can-Fite BioPharma Ltd. announced that it has completed enrollment of all patients planned for its Phase III Comfortâ„¢ study in patients with moderate to severe plaque psoriasis. [Can-Fite BioPharma Ltd.] |
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| October 19, 2021 London, England, United Kingdom |
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| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| University of Colorado – Aurora, Colorado, United States |
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| University of California Irvine – Irvine, California, United States |
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| The Scripps Research Institute – La Jolla, California, United States |
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| Buck Institute for Research on Aging – Novato, California, United States |
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