Dermal Cell News Volume 7.32 | Sep 13 2021

    0
    85






    2021-09-13 | DCN 7.32


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.32 – 13 September, 2021
    TOP STORY

    Developmental Chromatin Programs Determine Oncogenic Competence in Melanoma

    During development, neural crest cells give rise to melanoblasts, which then further differentiate into melanocytes. Using a combination of zebrafish transgenesis and human pluripotent stem cell models, researchers assessed oncogenic response to BRAFV600E in each of these three cell states.
    [Science]

    AbstractGraphical Abstract

    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    JUN Promotes Hypertrophic Skin Scarring via CD36 in Preclinical In Vitro and In Vivo Models

    Scientists used a hypertrophic scarring mouse model in which Jun was overexpressed globally or specifically in α-smooth muscle or collagen type I–expressing cells to cause excessive extracellular matrix deposition by skin fibroblasts in the skin after wounding.
    [Science Translational Medicine]

    Abstract

    Human Amniotic Stem Cells-Derived Exosmal miR-181a-5p and miR-199a Inhibit Melanogenesis and Promote Melanosome Degradation in Skin Hyperpigmentation, Respectively

    Researchers reported that both human amniotic stem cells and their conditional medium had a potent anti-hyperpigmentation in skin in vivo and in vitro.
    [Stem Cell Research & Therapy]

    Full Article

    Arsenic Leads to Autophagy of Keratinocytes by Increasing Aquaporin 3 Expression

    Scientists examined if blocking aquaporin 3 could interfere arsenic-induced autophagy in keratinocytes. Expression of aquaporin 3 was increased in arsenical cancers and in arsenic-treated keratinocytes.
    [Scientific Reports]

    Full Article

    Adipose-Derived Stem Cells Inhibit Dermal Fibroblast Growth and Induce Apoptosis in Keloids through the Arachidonic Acid-Derived Cyclooxygenase-2/Prostaglandin E2 Cascade by Paracrine

    Investigators found out how the conditioned medium of adipose-derived stem cells exerted an anti-fibrotic effect in keloid dermis-derived fibroblasts.
    [Burns & Trauma]

    Full Article

    Involvement of Felis catus Papillomavirus Type II in the Tumorigenesis of Feline Merkel Cell Carcinoma

    Scientists hypothesized that Felis catus papillomavirus was involved in the development of merkel cell carcinoma in cats, similar to Squamous cell carcinoma and basal cell carcinoma.
    [Veterinary Pathology]

    Abstract

    Hair Growth-Promotion Effects at the Cellular Level and Antioxidant Activity of the Plant-Based Extract Phyllotexâ„¢

    In vitro studies showed that the herbal formula stimulated cell proliferation of both dermal papilla and HaCaT cells and increased the phosphorylated form of the extracellular signal-regulated kinase 1 and 2, a well-known marker for cell proliferation.
    [Heliyon]

    Full Article

    Human Melanocyte Development and Melanoma Dedifferentiation at Single-Cell Resolution

    Researchers used a single-cell enrichment and RNA-sequencing pipeline to study human epidermal melanocytes directly from the skin, capturing transcriptomes across different anatomical sites, developmental age, sexes and multiple skin tones.
    [Nature Cell Biology]

    Abstract

    METTL14 Facilitates Global Genome Repair and Suppresses Skin Tumorigenesis

    Scientists showed that methyltransferase-like 14 (METTL14) , a critical component of the N6-methyladenosine (m6A) RNA methyltransferase complex, promoted global genome repair through regulating m6A mRNA methylation–mediated DDB2 translation and suppressed ultraviolet B radiation-induced skin tumorigenesis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Melanoma Cells Adopt Features of Both Mesenchymal and Amoeboid Migration within Confining Channels

    Using micro-fabricated channels, researchers demonstrated that metastatic, A375-M2, melanoma cells adopted features of both mesenchymal and bleb-based migration.
    [Scientific Reports]

    Full Article

    Irinotecan and Its Metabolite SN38 Inhibits Procollagen I Production of Dermal Fibroblasts from Systemic Sclerosis Patients

    Scientists evaluated the effects of noncytotoxic doses of irinotecan or its active metabolite SN38 on collagen production in systemic sclerosis fibroblasts.
    [Scientific Reports]

    Full Article

    Loss of miR-1469 Expression Mediates Melanoma Cell Migration and Invasion

    Researchers hypothesized that loss of miR-1469 expression in melanoma contributed to altered tumor cell functions mediating disease progression.
    [PLoS One]

    Full Article

    Virtual Conference Exhibition: Organoids
    REVIEWS

    How Good Is the Evidence That Cellular Senescence Causes Skin Aging?

    In case of skin, accumulation of senescence in all major compartments with aging is well documented and might be responsible for most, if not all, the molecular changes observed during aging. Incorporation of senescent cells into in vitro skin models recapitulates changes typically associated with skin aging.
    [Ageing Research Reviews]

    Abstract

    Analytical Approaches to Assess Metabolic Changes in Psoriasis

    Psoriasis is known to alter the expression of proteins that are involved in the inflammatory and antioxidant response, as well as protein biosynthesis, degradation, as well as cell proliferation and apoptosis.
    [Journal of Pharmaceutical and Biomedical Analysis]

    Abstract

    INDUSTRY AND POLICY NEWS

    Can-Fite Completes Patient Enrollment in Phase III Psoriasis Study

    Can-Fite BioPharma Ltd. announced that it has completed enrollment of all patients planned for its Phase III Comfortâ„¢ study in patients with moderate to severe plaque psoriasis.
    [Can-Fite BioPharma Ltd.]

    Press Release

    FEATURED EVENT

    Annual London Stem Cell Network Symposium

    October 19, 2021
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Senior Scientist/Postdoctoral Fellow – Human Skin Disease and Regenerative Medicine

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Assistant Professor – Immunology, Microbiology of Skin and Vaginal Mucosa

    University of Colorado – Aurora, Colorado, United States

    Postdoctoral Researcher – Skin Organoid

    University of California Irvine – Irvine, California, United States

    Research Assistant – Pharmacology

    The Scripps Research Institute – La Jolla, California, United States

    Postdoctoral Fellow – Liquid Chromatography-Mass Spectrometry

    Buck Institute for Research on Aging – Novato, California, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter