Dermal Cell News Volume 7.34 | Sep 27 2021

    By
    Justin.choi
    -
    0
    55







    2021-09-27 | DCN 7.34


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.34 – 27 September, 2021
    TOP STORY

    Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin

    By forced expression of the ectodysplasin-A in human epidermal keratinocytes sweat gland (SwG) culture medium, human epidermal keratinocytes were efficiently converted into SwG cells.
    [Advanced Science]

    Full Article
    Request a free copy of the Growing Organoids from Stem Cells Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Norrie Disease Protein Is Essential for Cochlear Hair Cell Maturation

    Norrie disease causes deafness, blindness, and intellectual disability. Scienitsts showed that Norrie disease protein controls a network of transcriptional regulators required for maturation and maintenance of cochlear hair cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    EGFR-Mediated Epidermal Stem Cell Motility Drives Skin Regeneration through COL17A1 Proteolysis

    Researchers conducted culture experiments that proved epidermal growth factor receptor (EGFR) activation drove human keratinocyte stem cell motility.
    [Journal of Cell Biology]

    Abstract

    Integrin α5β1 Nano-Presentation Regulates Collective Keratinocyte Migration Independent of Substrate Rigidity

    The authors used a highly specific integrin α5β1 peptidomimetic combined with nanopatterned hydrogels to show that keratinocyte sheets regulated their migration ability at an optimal integrin α5β1 nanospacing.
    [eLife]

    Full Article

    GPCR-Mediated EGFR Transactivation Ameliorates Skin Toxicities Induced by Afatinib

    Scientists examined the ability of three different G-protein-coupled receptor (GPCR) agonists to reverse signaling inhibition and ameliorate rash induced by epidermal growth factor receptor inhibitors (EGFRi).
    [Acta Pharmacologica Sinica]

    Abstract

    Effect of 1-MHz Ultrasound on the Proinflammatory Interleukin-6 Secretion in Human Keratinocytes

    Researchers investigated whether mechanical energy transported by low intensity ultrasound could generate a mechanical stress able to induce the release of inflammatory cytokine such as interleukin-6 in the human keratinocyte cell line, HaCaT.
    [Scientific Reports]

    Abstract

    Establishment of a Striped Catfish Skin Explant Model for Studying the Skin Response in Aeromonas hydrophila Infections

    The authors used striped catfish to establish an ex vivo skin explant tissue culture model to explore host pathogen interaction. They concluded that this ex vivo skin explant model could serve as a teleost skin infection model for monitoring pathogenesis under various infection conditions.
    [Scientific Reports]

    Full Article

    Silencing of Nesprin-2 Inhibits the Differentiation of Myofibroblasts from Fibroblasts Induced by Mechanical Stretch

    Investigators constructed a cell model of hypertrophic scar (HTs) and explored the role of Nesprin-2 in this process. Myofibroblasts and fibroblasts were isolated from HTs and healthy skin tissues of the same patient.
    [International Wound Journal]

    Full Article

    Antitumorigenic Effect of Insect-Derived Peptide Poecilocorisin-1 in Human Skin Cancer Cells through Regulation of Sp1 Transcription Factor

    The insect-derived peptide poecilocorisin-1 (PCC-1) did not induce toxicity in the human epithelial cell line HaCaT, but its potential as an anticancer agent was confirmed through specific effects of antiproliferation, apoptosis, and cell cycle arrest in two melanoma cell lines, SK-MEL-28 and G361.
    [Scientific Reports]

    Abstract

    Antiproliferative Activity of Aqueous and Polyphenol-Rich Extracts of Larrea divaricata Cav. on a Melanoma Cell Line

    The effects of Larrea divaricata, polyphenols and quercetin-3-methyl ether were assessed on B16F10 melanoma cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3.
    [Natural Product Research]

    AbstractGraphical Abstract

    Start Fast. Finish Faster. Streamline your assays with purified human primary cells from STEMCELL Technologies. View products now.
    REVIEWS

    Dynamic Changes in Epithelial Cell Packing during Tissue Morphogenesis

    Scientists highlight how morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. They describe approaches that have the potential to engineer 3D tissues for both basic science and translational purposes.
    [Current Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Sebia and Metafora Biosystems Form Strategic Partnership to Develop Advanced In Vitro Diagnostics Tests

    Sebia, a world leader in diagnostics in the fields of multiple myeloma and chronic diseases, and Metafora biosystems announced a strategic partnership to develop a portfolio of in vitro diagnostics solutions based on Metafora’s technology platform.
    [Sebia (BioSpace, Inc.)]

    Press Release

    Athenex Announces Phased European Launch of Klisyri® (Tirbanibulin) for the Treatment of Actinic Keratosis

    Anthenex launched Klisyri® in Germany and the UK. Klisyri received approval by the European Commission and the UK Medicines & Healthcare products Regulatory Agency in July and August of 2021, respectively, for the topical treatment of actinic keratosis of the face and scalp in adults.
    [Athenex, Inc.]

    Press Release
    FEATURED EVENT

    AACR Virtual Special Conference: Tumor Immunology and Immunotherapy

    October 5 – 6, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Faculty and Leadership Positions – Cancer-Focused Target and Drug Discovery

    The University of New Mexico – Albuquerque, New Mexico, United States

    Scientist – Endocrine Disease Specialist

    Novo Nordisk – Indianapolis, Indiana, United States

    Postdoctoral Associate – Skin Tumorigenesis

    University of Minnesota – Austin, Minnesota, United States

    Senior Scientist/ Postdoctoral Fellow – Human Skin Disease and Regenerative Medicine

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Assistant Professor – Immunology, Microbiology of Skin and Vaginal Mucosa

    University of Colorado – Aurora, Colorado, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter