Dermal Cell News Volume 7.36 | Oct 18 2021

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    2021-10-18 | DCN 7.36


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.36- 18 October, 2021
    TOP STORY

    Hair Shaft Miniaturization Causes Stem Cell Depletion through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis

    Investigators demonstrated that hair shaft loss or reduced diameter shrunk the physical niche size, which resulted in mechanical compression of hair follicle stem cells and their apoptotic loss.
    [Cell Stem Cell]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Integrated Spatial Multiomics Reveals Fibroblast Fate during Tissue Repair

    Scientists presented a multimodal -omics platform for the comprehensive study of cell populations in complex tissue, which allowed them to characterize the cells involved in wound healing across both time and space.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Oleuropein Multicompartment Nanovesicles Enriched with Collagen as a Natural Strategy for the Treatment of Skin Wounds Connected with Oxidative Stress

    Collagen-enriched transfersomes, glycerosomes and glytransfersomes were specifically tailored by investigators for skin delivery of oleuropein.
    [Nanomedicine]

    Abstract

    Novel Scaffold Based Graphene Oxide Doped Electrospun Iota Carrageenan/Polyvinyl Alcohol for Wound Healing and Pathogen Reduction: In Vitro and In Vivo Study

    The authors worked with electrospun nanofiber scaffold named that was composed of polyvinyl alcohol/iota carrageenan and doped with partially reduced graphene oxide that was successfully synthesized for wound healing and skin repair.
    [Scientific Reports]

    Full Article

    Therapeutic Melanoma Inhibition by Local Micelle-Mediated Cyclic Nucleotide Repression

    Researchers demonstrated that single-cell sequencing of melanoma-infiltrating immune cells showed that adenylate cyclase inhibitor micelles reduced the number of anti-inflammatory myeloid cells and checkpoint receptor expression on T cells.
    [Nature Communications]

    Full Article

    C-FOS Drives Reversible Basal to Squamous Cell Carcinoma Transition

    Investigators used surface markers of resistant basal cell carcinomas and patient single-cell and bulk transcriptomic data, and uncovered the dynamic roadmap of basal to squamous cell carcinoma transition.
    [Cell Reports]

    Full ArticleGraphical Abstract

    IER2-Induced Senescence Drives Melanoma Invasion through Osteopontin

    The authors observed coordinate expression of IER2, p53/p21, and osteopontin in primary human melanomas and metastases, which highlighted the pathophysiological relevance of IER2-mediated senescence in melanoma progression.
    [Oncogene]

    Full Article

    Metastatic and Non-Metastatic Melanoma Imaging Using Sgc8-C Aptamer PTK7-Recognizer

    Scientists evaluated Sgc8-c in a metastatic melanoma model as a molecular imaging probe for in vivo diagnostic, and two probes were in vitro evaluated verifying the high specific PTK7 recognition and its internalization in tumor cells by the endosomal route.
    [Scientific Reports]

    Full Article

    Nobiletin-Loaded Composite Penetration Enhancer Vesicles Restore the Normal miRNA Expression and the Chief Defence Antioxidant Levels in Skin Cancer

    The authors loaded nobiletin in various vesicular systems to improve its cytotoxicity against skin cancer. Vesicles were prepared using the thin film hydration method, and characterized for particle size, zeta potential, entrapment efficiency, TEM, ex-vivo skin deposition and physical stability.
    [Scientific Reports]

    Full Article

    Molecular Characterization of Biphenotypic Epithelioid and Plexiform Melanoma with Deep Penetrating Nevus (DPN)-Like Features

    Researchers investigated a case of melanoma that displayed a dual phenotype: a DPN-like/plexiform portion in conjunction with a conventional epithelioid morphology.
    [Pigment Cell & Melanoma Research]

    Abstract
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    REVIEWS

    Building and Maintaining the Skin

    Investigators review diverse cellular interactions and highlight how far-reaching signals can be transmitted at the local level to enable skin stem cells to tailor their actions to suit the particular occasion and optimize fitness.
    [Cold Spring Harbor Perspectives in Biology]

    Abstract

    Insight into the Role of Dermal White Adipose Tissue Loss in Dermal Fibrosis

    The authors indicate that the adipocytes-to-myofibroblasts transition in dermal white adipose tissue reflects the direct contribution to the dermal fibrosis formation.
    [Journal of Cellular Physiology]

    Abstract

    Combining Systemic and Locally Applied Cellular Therapies for the Treatment of Systemic Sclerosis

    Scientists provide an overview of the cellular therapies available for the management of systemic sclerosis, including systemically injected therapies and locally administered regenerative cell therapies.
    [Bone Marrow Transplantation]

    Abstract
    INDUSTRY AND POLICY NEWS

    Krystal Biotech and GeneDx Announce Collaboration to Provide No-Charge Genetic Testing for Patients with Suspected Dystrophic Epidermolysis Bullosa (DEB)

    Krystal Biotech, Inc. and GeneDx, Inc. announced a collaboration offering no-charge genetic testing for all types of Epidermolysis Bullosa.
    [Krystal Biotech, Inc.]

    Press Release

    RedDress Earns a Strategic Partnership with MediGroup

    RedDress announced that it has entered into a partnership with MediGroup to deliver its innovative wound care solution, ActiGraft® system to MediGroup’s members.
    [RedDress (GlobeNewsWire, Inc.)]

    Press Release
    FEATURED EVENT

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    Society for Neuroscience 2021

    November 8 – 16, 2021
    Chicago, Ilinois, United States & Online
    JOB OPPORTUNITIES

    Postdoctoral Scientist – Skin Cancer and Aging Group

    Cancer Research UK Manchester Institute – Manchester, United Kingdom

    Faculty and Leadership Positions – Cancer-Focused Target and Drug Discovery

    The University of New Mexico – Albuquerque, New Mexico, United States

    Scientist – Endocrine Disease Specialist

    Novo Nordisk – Indianapolis, Indiana, United States

    Postdoctoral Associate – Skin Tumorigenesis

    University of Minnesota – Austin, Minnesota, United States

    Senior Scientist/ Postdoctoral Fellow – Human Skin Disease and Regenerative Medicine

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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