 | | Vol. 7.41 – 22 November, 2021 |
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| Researchers showed that mice having a keratinocyte-specific deletion of Fn14, the receptor for the tumor necrosis factor (TNF) superfamily cytokine TWEAK, displayed reduced imiquimod-induced skin inflammation, diminished epidermal hyperplasia and less expression of psoriasis signature genes.
[Science Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Melittin (MEL)-diclofenac (DCL) nano-complexes exhibited better regenerated epithelium, keratinization, epidermal proliferation, and granulation tissue formation and better wound healing activity than controls. Treatment of wounded skin with MEL-DCL nano-complexes showed increased mRNA levels of collagen.
[Pharmacological Research] |
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| Scientists investigated if α-tocopherol phosphate, a promising new antioxidant, could protect against long-wave UVA1 induced cell death and scavenge UVA1 induced reactive oxygen species in a skin cell model.
[Scientific Reports] |
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| The authors investigated the wound healing potential of okra fruit by in vitro and in vivo experimental models. The biocompatibility of the gel formulations prepared with the best performing extract were evaluated by human Epidermâ„¢ reconstituted skin irritation test model.
[Journal of Ethnopharmacology] |
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| To clarify the role of ERK5 in melanoma growth, scientists performed transcriptomic analyses following ERK5 knockdown in melanoma cells expressing BRAFV600E and found that cellular senescence was among the most affected processes.
[Cancer Research] |
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| Emerging evidence indicated B cell activating factor (BAFF) to be an important cytokine for anti-tumor immunity. Investigators generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grew more slowly in vivo than control tumors.
[Cancer Research] |
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| Scientists reported that matrix metalloproteinase 9 (MMP-9) localized to the nucleus of melanoma cells and potentiated gene expression by proteolytically clipping the histone H3 N-terminal tail.
[Oncogene] |
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| Tumor growth and metastasis are heavily affected by the P2X7 receptor and microvesicles and exosomes released into the microenvironment. Researchers showed that P2X7 was overexpressed in patients affected by metastatic malignant melanoma and its expression was closely correlated with reduced overall survival.
[Cell Death & Disease] |
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| The authors demonstrated that 5-(4-hydroxyphenyl)−3H-1,2-dithiocyclopentene-3-thione (ADT-OH) inhibited the epithelial-mesenchymal transition process in melanoma cells by suppressing the CSE/CBS and FAK signaling pathways, thereby exerting its antimetastatic activity.
[Acta Pharmacologica Sinica] |
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| Scientists investigated the efficacy of the histone deacetylase inhibitor, Vorinostat, in targeting hyperproliferation and impaired apoptosis in psoriatic skin.
[Experimental Dermatology] |
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| Persistent pruritus and excessive scratching behavior can lead to the itch–scratch cycle that exacerbates inflammatory skin diseases. The authors discuss molecularly targeted drugs, such as IL-31 or IL-4 receptor–targeting antibodies, that have become available or are under clinical trials.
[Journal of Investigative Dermatology] |
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| Exogenous extracellular vesicles (EVs) demonstrate striking efficacy in resolution of preclinical wound models. Investigators provide a comprehensive review of procedural parameters and the subsequent tissue, cellular and molecular impact of the derived EVs in different skin wounds/disorders.
[Advances in Wound Care] |
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| Connect Biopharma Holdings Limited reported positive topline results from the global Phase II clinical trial of CBP-201 administered subcutaneously to adult patients with moderate-to-severe atopic dermatitis.
[Connect Biopharma Holdings Limited] |
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| Verrica Pharmaceuticals, Inc. announced that the US FDA has accepted the company’s Investigational New Drug Application (IND) for LTX-315 for the treatment of basal cell carcinoma.
[Verrica Pharmaceuticals, Inc.] |
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| December 5 – 9, 2021
Jupiter, Florida, United States |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Ulsan National Institute of Science and Technology – Ulsan, South Korea |
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