| Vol. 7.42 – 29 November, 2021 |
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| Using melanoma as a model, researchers showed that TBX2 lied downstream from PI3K signaling and that TBX2 binds and was required for expression of E2F1, a key antisenescence cell cycle regulator. [Genes & Development] |
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PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| Multifunctional bilayered dermal patches with antibacterial, antioxidant and anti-inflammatory properties were developed and compared for performance. Soluble eggshell membrane protein improved the migration of human adult dermal fibroblasts, suggesting its contribution to wound healing. [Nanomedicine-Nanotechnology Biology and Medicine] |
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| Scientists demonstrated that polymethoxyflavones purified from K. parviflora rhizomes suppressed cellular senescence, reactive oxygen species, and the senescence-associated secretory phenotype in primary human dermal fibroblasts. [Biomedicine & Pharmacotherapy] |
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| The authors evaluated the in vitro and in vivo properties of a novel liquid dermal scaffold in a delayed murine full thickness wound model. They compared this scaffold with two commercially-available granular collagen-based products [Experimental Dermatology] |
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| Investigators evaluated the potential of quercetin and its structurally related flavonoid taxifolin to reduce UVA-caused damage to human primary dermal fibroblasts and epidermal keratinocytes obtained from identical donors. [Photochemical & Photobiological Sciences] |
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| Scientists comprehensively identified the role of hematopoietic cell-specific protein 1-associated protein X-1 in the inhibition of lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in human dermal fibroblasts. [Wound Repair and Regeneration] |
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| Researchers investigated the potential contribution of LIGHT to systemic sclerosis (SSc) development using clinical samples and animal models. In SSc-involved skin, LIGHT was up-regulated in inflammatory cells, while HVEM, a receptor of LIGHT, was down-regulated in dermal fibroblasts. [Journal of Investigative Dermatology] |
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| Three patient-derived cancer cells (PDCs) were established from NRAS Q61-positive metastatic melanoma patients. The response of PDCs and five established melanoma cell lines was evaluated toward a panel of 527 oncology drugs using high-throughput drug sensitivity and resistance testing. [Translational Oncology] |
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| Scientists demonstrated that melanoma-produced exosomes significantly stimulated the tumor-promoting proinflammatory activity of cancer-associated fibroblasts. [Histochemistry and Cell Biology] |
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| Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the presence of painful nodules, abscesses, chronically draining fistulas, and scarring in apocrine gland-bearing areas of the body. The authors describe evidence for the effectiveness of current and emerging HS therapies. [Therapeutic Advances in Chronic Disease] |
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| Scientists summarize available evidence of the role of the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome in impaired wound healing and describe strategies to inhibit the inflammasome to improve wound healing. [Advances in Wound Care] |
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| Bristol Myers Squibb announced that the US FDA has accepted the New Drug Application and the European Medicines Agency has validated the Marketing Authorization Application for deucravacitinib for the treatment of adults with moderate to severe plaque psoriasis. [Bristol Myers Squibb] |
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| January 9 – 12, 2022 Portland, Oregon, United States |
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| Heidelberg University – Heidelberg, Germany |
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| European Molecular Biology Laboratory – Heidelberg, Germany |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Ulsan National Institute of Science and Technology – Ulsan, South Korea |
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