Dermal Cell News Volume 7.42 | Nov 29 2021

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    2021-11-29 | DCN 7.42


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.42 – 29 November, 2021
    TOP STORY

    TBX2 Controls a Proproliferative Gene Expression Program in Melanoma

    Using melanoma as a model, researchers showed that TBX2 lied downstream from PI3K signaling and that TBX2 binds and was required for expression of E2F1, a key antisenescence cell cycle regulator.
    [Genes & Development]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Novel Combination of Bioactive Agents in Bilayered Dermal Patches Provides Superior Wound Healing

    Multifunctional bilayered dermal patches with antibacterial, antioxidant and anti-inflammatory properties were developed and compared for performance. Soluble eggshell membrane protein improved the migration of human adult dermal fibroblasts, suggesting its contribution to wound healing.
    [Nanomedicine-Nanotechnology Biology and Medicine]

    AbstractGraphical Abstract

    Polymethoxyflavones from Kaempferia parviflora Ameliorate Skin Aging in Primary Human Dermal Fibroblasts and Ex Vivo Human Skin

    Scientists demonstrated that polymethoxyflavones purified from K. parviflora rhizomes suppressed cellular senescence, reactive oxygen species, and the senescence-associated secretory phenotype in primary human dermal fibroblasts.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Studying the In Vivo Application of a Liquid Dermal Scaffold in Promoting Wound Healing in a Mouse Model

    The authors evaluated the in vitro and in vivo properties of a novel liquid dermal scaffold in a delayed murine full thickness wound model. They compared this scaffold with two commercially-available granular collagen-based products
    [Experimental Dermatology]

    Abstract

    Effect of the Flavonoids Quercetin and Taxifolin on UVA-Induced Damage to Human Primary Skin Keratinocytes and Fibroblasts

    Investigators evaluated the potential of quercetin and its structurally related flavonoid taxifolin to reduce UVA-caused damage to human primary dermal fibroblasts and epidermal keratinocytes obtained from identical donors.
    [Photochemical & Photobiological Sciences]

    Full ArticleGraphical Abstract

    Role of Hematopoietic Cell-Specific Protein 1-Associated Protein X-1 Gene in Lipopolysaccharide-Induced Apoptosis of Human Dermal Fibroblasts

    Scientists comprehensively identified the role of hematopoietic cell-specific protein 1-associated protein X-1 in the inhibition of lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in human dermal fibroblasts.
    [Wound Repair and Regeneration]

    Abstract

    The Contribution of LIGHT to the Development of Systemic Sclerosis by Modulating IL-6 and Th1 Chemokine Expression in Dermal Fibroblasts

    Researchers investigated the potential contribution of LIGHT to systemic sclerosis (SSc) development using clinical samples and animal models. In SSc-involved skin, LIGHT was up-regulated in inflammatory cells, while HVEM, a receptor of LIGHT, was down-regulated in dermal fibroblasts.
    [Journal of Investigative Dermatology]

    Abstract

    High-Throughput Ex Vivo Drug Testing Identifies Potential Drugs and Drug Combinations for NRAS-Positive Malignant Melanoma

    Three patient-derived cancer cells (PDCs) were established from NRAS Q61-positive metastatic melanoma patients. The response of PDCs and five established melanoma cell lines was evaluated toward a panel of 527 oncology drugs using high-throughput drug sensitivity and resistance testing.
    [Translational Oncology]

    Full Article

    Exosomes Produced by Melanoma Cells Significantly Influence the Biological Properties of Normal and Cancer-Associated Fibroblasts

    Scientists demonstrated that melanoma-produced exosomes significantly stimulated the tumor-promoting proinflammatory activity of cancer-associated fibroblasts.
    [Histochemistry and Cell Biology]

    Full Article
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    REVIEWS

    New Perspectives on the Treatment of Hidradenitis Suppurativa

    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the presence of painful nodules, abscesses, chronically draining fistulas, and scarring in apocrine gland-bearing areas of the body. The authors describe evidence for the effectiveness of current and emerging HS therapies.
    [Therapeutic Advances in Chronic Disease]

    Full Article

    Targeting the NLRP3 Inflammasome to Improve Healing of Diabetic Wounds

    Scientists summarize available evidence of the role of the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome in impaired wound healing and describe strategies to inhibit the inflammasome to improve wound healing.
    [Advances in Wound Care]

    Abstract
    INDUSTRY AND POLICY NEWS

    Bristol Myers Squibb’s Applications for Deucravacitinib for the Treatment of Moderate to Severe Plaque Psoriasis Accepted by US Food and Drug Administration and Validated by European Medicines Agency

    Bristol Myers Squibb announced that the US FDA has accepted the New Drug Application and the European Medicines Agency has validated the Marketing Authorization Application for deucravacitinib for the treatment of adults with moderate to severe plaque psoriasis.
    [Bristol Myers Squibb]

    Press Release
    FEATURED EVENT

    AACR: Cancer Metastasis

    January 9 – 12, 2022
    Portland, Oregon, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Mechanisms of Allergic Disease

    Heidelberg University – Heidelberg, Germany

    Research Technician – Adult Mammalian Skin

    European Molecular Biology Laboratory – Heidelberg, Germany

    Postdoctoral Fellow – Melanoma Development

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Automation Scientist – Pluripotent Cells

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Researcher – Materials Science

    Ulsan National Institute of Science and Technology – Ulsan, South Korea

    > See All Jobs

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