| Vol. 7.43 – 6 December, 2021 |
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| Scientists characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells. [Journal of Clinical Investigation] |
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PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| The authors reported that polypeptide hydrogels achieved scarless and full wound healing and regenerated thick dermis with some embedded hair follicles within 14 days, presenting superior full-thickness wound healing and skin scar-preventing capabilities. [Advanced Healthcare Materials] |
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| To establish a well-defined 3D cell culture model to mimic the tissue repair process, researchers utilized THP-1 human monocytic cells and a 3D collagen matrix as a biomimetic tissue model. [NPJ Regenerative Medicine] |
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| The authors illustrated that varying coating material for silver nanoparticles stabilization resulted in differential toxicity against dermal microbes and HaCaT keratinocytes in vitro and affected dermal absorption through intact/compromised skin in vivo. [Chemosphere] |
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| In vitro fibroblast cell viability and migration potential of the scaffolds were determined by MTT, live/dead staining, and scratch assay for wound healing. The scratch assessments determined better cell migration and wound closure in treating with polymeric and tetracalcium phosphate-containing scaffolds. [Journal of Biomaterials Science-Polymer Edition] |
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| Scientists investigated the in vitro cytotoxic effect of previously developed nanocapsules, nanoemulsion, and microemulsion based on bullfrog oil against human melanoma cells. [Biomedicine & Pharmacotherapy] |
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| Proteomic analysis was conducted to derive the cellular responses induced by an environmentally relevant dose of ultraviolet-A (UVA) in primary human keratinocytes. The authors investigated the effects of UVA on non-transformed immortalized keratinocytes. [Scientific Reports] |
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| Exposure to trametinib and azacitidine prevented development of trametinib resistance in NRAS-mutated human melanoma cells in vitro. Azacitidine acted synergistically with trametinib to inhibit the growth of trametinib-resistant melanoma cells. [Pediatric Blood & Cancer] |
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| Researchers reported that berberine had important antiproliferative effects and might be alone or in adjunct therapy a promising candidate for melanoma treatment, a cancer with great incidence and high lethality. [Molecular Biology Reports] |
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| The design and fabrication methods of conductive biomaterials with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, and acellular dermal matrix for applications in wound healing and skin tissue engineering is summarized. [Nano-Micro Letters] |
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| Investigators explain the principles of different approaches of gene therapy, summarize its journey and discuss its current and future impact in recessive dystrophic epidermolysis bullosa. [British Journal of Dermatology] |
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| Scientists summarize the recent findings concerning the application of mesenchymal stem/stromal stem cells and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports. [Stem Cell Research & Therapy] |
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| Merck announced that the US FDA has approved KEYTRUDA, Merck’s anti-PD-1 therapy, for the adjuvant treatment of adult and pediatric patients with stage IIB or IIC melanoma following complete resection. [Merck, Inc.] |
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| Ultimovacs ASA announces that the US FDA has granted orphan drug designation for the company’s universal cancer vaccine UV1 for the treatment of stage IIB – IV melanoma. [Ultimovacs ASA] |
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| January 16 – 20, 2022 Banff, Alberta, Canada |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| Heidelberg University – Heidelberg, Germany |
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| European Molecular Biology Laboratory – Heidelberg, Germany |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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