Dermal Cell News Volume 7.43 | Dec 6 2021

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    2021-12-06 | DCN 7.43


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.43 – 6 December, 2021
    TOP STORY

    Congenital Deficiency Reveals Critical Role of ISG15 in Skin Homeostasis

    Scientists characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Multifunctional Single-Component Polypeptide Hydrogels: The Gelation Mechanism, Superior Biocompatibility, High Performance Hemostasis, and Scarless Wound Healing

    The authors reported that polypeptide hydrogels achieved scarless and full wound healing and regenerated thick dermis with some embedded hair follicles within 14 days, presenting superior full-thickness wound healing and skin scar-preventing capabilities.
    [Advanced Healthcare Materials]

    Abstract

    3D In Vitro M2 Macrophage Model to Mimic Modulation of Tissue Repair

    To establish a well-defined 3D cell culture model to mimic the tissue repair process, researchers utilized THP-1 human monocytic cells and a 3D collagen matrix as a biomimetic tissue model.
    [NPJ Regenerative Medicine]

    Full Article

    Unravelling the Role of Surface Modification in the Dermocompatibility of Silver Nanoparticles In Vitro and In Vivo

    The authors illustrated that varying coating material for silver nanoparticles stabilization resulted in differential toxicity against dermal microbes and HaCaT keratinocytes in vitro and affected dermal absorption through intact/compromised skin in vivo.
    [Chemosphere]

    AbstractGraphical Abstract

    Wound Closure, Angiogenesis and Antibacterial Behaviors of Tetracalcium Phosphate/Hydroxyethyl Cellulose/Hyaluronic Acid/Gelatin Composite Dermal Scaffolds

    In vitro fibroblast cell viability and migration potential of the scaffolds were determined by MTT, live/dead staining, and scratch assay for wound healing. The scratch assessments determined better cell migration and wound closure in treating with polymeric and tetracalcium phosphate-containing scaffolds.
    [Journal of Biomaterials Science-Polymer Edition]

    Abstract

    Nanostructured Systems Increase the In Vitro Cytotoxic Effect of Bullfrog Oil in Human Melanoma Cells (A2058)

    Scientists investigated the in vitro cytotoxic effect of previously developed nanocapsules, nanoemulsion, and microemulsion based on bullfrog oil against human melanoma cells.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    A Single Dose of Ultraviolet-A Induces Proteome Remodeling and Senescence in Primary Human Keratinocytes

    Proteomic analysis was conducted to derive the cellular responses induced by an environmentally relevant dose of ultraviolet-A (UVA) in primary human keratinocytes. The authors investigated the effects of UVA on non-transformed immortalized keratinocytes.
    [Scientific Reports]

    Full Article

    Combinatorial Effects of Azacitidine and Trametinib on NRAS-Mutated Melanoma

    Exposure to trametinib and azacitidine prevented development of trametinib resistance in NRAS-mutated human melanoma cells in vitro. Azacitidine acted synergistically with trametinib to inhibit the growth of trametinib-resistant melanoma cells.
    [Pediatric Blood & Cancer]

    Full Article

    Berberine Increases the Expression of Cytokines and Proteins Linked to Apoptosis in Human Melanoma Cells

    Researchers reported that berberine had important antiproliferative effects and might be alone or in adjunct therapy a promising candidate for melanoma treatment, a cancer with great incidence and high lethality.
    [Molecular Biology Reports]

    Abstract
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    REVIEWS

    Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

    The design and fabrication methods of conductive biomaterials with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, and acellular dermal matrix for applications in wound healing and skin tissue engineering is summarized.
    [Nano-Micro Letters]

    Full ArticleGraphical Abstract

    The Potential of Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa

    Investigators explain the principles of different approaches of gene therapy, summarize its journey and discuss its current and future impact in recessive dystrophic epidermolysis bullosa.
    [British Journal of Dermatology]

    Abstract

    MSCs and Their Exosomes: A Rapidly Evolving Approach in the Context of Cutaneous Wounds Therapy

    Scientists summarize the recent findings concerning the application of mesenchymal stem/stromal stem cells and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    FDA Approves Merck’s KEYTRUDA® (pembrolizumab) as Adjuvant Treatment for Adult and Pediatric (above 12 Years of Age) Patients With Stage IIB or IIC Melanoma Following Complete Resection

    Merck announced that the US FDA has approved KEYTRUDA, Merck’s anti-PD-1 therapy, for the adjuvant treatment of adult and pediatric patients with stage IIB or IIC melanoma following complete resection.
    [Merck, Inc.]

    Press Release

    Ultimovacs Granted Orphan Drug Designation by FDA for UV1 Cancer Vaccine in Metastatic Melanoma

    Ultimovacs ASA announces that the US FDA has granted orphan drug designation for the company’s universal cancer vaccine UV1 for the treatment of stage IIB – IV melanoma.
    [Ultimovacs ASA]

    Press Release
    FEATURED EVENT

    Immunometabolism at the Crossroads of Obesity and Cancer

    January 16 – 20, 2022
    Banff, Alberta, Canada

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    JOB OPPORTUNITIES

    Research Fellow – RNA Surveillance

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Position – Mechanisms of Allergic Disease

    Heidelberg University – Heidelberg, Germany

    Research Technician – Adult Mammalian Skin

    European Molecular Biology Laboratory – Heidelberg, Germany

    Postdoctoral Fellow – Melanoma Development

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Automation Scientist – Pluripotent Cells

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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