 | | Vol. 8.02 – 24 January, 2022 |
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| BRAF inhibitor induced BRAF-CRAF heterodimerization and subsequent activation of ERK signaling in cancer-associated fibroblasts, leading to inactivation of the β-catenin destruction complex.
[Cancer Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| The hit compound (Dwn1) suppressed circadian Npas2 expression, increased murine dermal fibroblast cell migration, and decreased collagen synthesis in vitro.
[eLife] |
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| The authors explained the incidence of hand-foot skin reaction in patients treated with tyrosine kinase inhibitors by focusing on keratinocyte toxicity and inhibition of vascular endothelial growth factor receptor, which played an essential role in angiogenesis.
[Biochemical Pharmacology] |
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| Researchers described a possible mechanism involved in skin aging focusing on the effect of trehangelins on epidermal cellular communication metwork factor 1 (CCN1).
[Scientific Reports] |
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| Investigators suggested that reconstructing the basement membrane promoted the secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis.
[Scientific Reports] |
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| Scientists found that matrix metalloproteinases were responsible for ultraviolet (UV)-mediated collagen 17A degradation in both in vitro keratinocytes and in vivo mouse skin.
[Journal of Cell Communication and Signaling] |
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| Investigators demonstrated that Kelch-like protein 24 (KLHL24) played a role in hair maintenance by regulating the cytoskeleton structure of hair follicle stem cells (HFSCs) and highlighted the importance of the ubiquitin-proteasome system in the stability of HFSCs.
[Journal of Investigative Dermatology] |
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| Researchers stimulated post-confluent human keratinocytes and living skin equivalent with TSLP to investigate the role of nuclear IL-33 in TSLP-induced epidermal barrier defects.
[Journal of Investigative Dermatology] |
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| Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and melanin content in B16F10 melanoma cells.
[Biomedicine & Pharmacotherapy] |
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| Investigators evaluated the simultaneous exposure of melanoma cells to flavones and the static magnetic fields that were generated by permanent magnets on the gene expression and the activity of the antioxidant enzymes that were associated with the antioxidant defence system.
[Molecular Biology Reports] |
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| The authors review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions.
[Cell Death & Disease] |
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| Scientists review the most recent evidence concerning mycobacterial skin infections, limiting the period of literature research to 2020–2021.
[Current Opinion in Infectious Diseases] |
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| ASLAN Pharmaceuticals announced that it has screened the first patient in its Phase IIb dose-ranging clinical study of eblasakimab in adults with moderate-to-severe atopic dermatitis.
[ASLAN Pharmaceuticals] |
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| VYNE Therapeutics, Inc. announced that it has completed the Phase Ib portion of a Phase Ib/IIa clinical trial evaluating FMX114 for the treatment of mild-to-moderate atopic dermatitis.
[VYNE Therapeutics, Inc.] |
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| March 9 – 11, 2022
Melbourne, Victoria, Australia |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | University of California Los Angeles – Los Angeles, California, United States |
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| | Howard Hughes Medical Institute – Dallas, Texas, United States |
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| | University Hospital of Lausanne – Lausanne, Vaud, Switzerland |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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