 | | Vol. 8.04 – 7 February, 2022 |
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| Investigators examined human atopic dermatitis (AD) skin samples and found that human AD fibroblasts also overexpressed C-C motif chemokine ligand 11 (CCL11) and that perturbation of Ikkb–NF-κB in primary human dermal fibroblasts up-regulated CCL11.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers investigated the impact of CD26 deficiency in human primary fibroblasts on the regeneration of human tissue-engineered skin substitutes in vivo.
[Scientific Reports] |
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| Scientists evaluated the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and revealed the Wnt/β-catenin pathway and telomerase reverse transcriptase involved mechanisms.
[Journal of Ethnopharmacology] |
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| Glucose 6-phosphate dehydrogenase (G6PD) mutant melanomas had significantly decreased G6PD enzymatic activity and depletion of intermediates in the oxidative pentose phosphate pathway.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists assessed the composition and production mechanisms, as well as the clinical significance and biological properties, of soluble CD74 in melanoma.
[Cell Death & Disease] |
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| The authors explored the mechanisms of extracellular vesicles-carried long non-coding RNA NEAT1 involvement in melanoma.
[Cancer Gene Therapy] |
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| High-throughput sequencing and bioinformatic analysis were employed to identify differentially expressed RNAs in platelet signatures of mice injected with a suboptimal number of melanoma cells compared with mice with macroscopic melanomas and negative controls.
[Journal of Translational Medicine] |
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| Hepatic metastases was induced by intrasplenic injection of five different murine melanoma cell lines. The efficiencies of hepatic colonization, morphologic patterns, gene expression profiles and degree of vascularization were analyzed and Sorafenib was applied as anti-angiogenic treatment.
[Journal of Translational Medicine] |
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| Investigators co-cultured immortalized balding and non-balding human dermal papilla cells derived from male androgenetic alopecia patients with epidermal keratinocytes using a multi-interfacial polyelectrolyte complexation technique.
[Experimental Dermatology] |
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| The authors provide an update of what has currently been reported in the last 30 year literature about several new or emerging conditions of acquired cutaneous mucinoses in adults.
[Journal of the European Academy of Dermatology and Venereology] |
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| Clinicians should anticipate palmoplantar pustulosis or palmoplantar pustular psoriasis as potential drug reactions to biologics such as adalimumab and infliximab.
[International Journal of Dermatology] |
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| Evelo Biosciences, Inc. announced the results of immunological biomarker analyses from its previously reported Phase II trial of orally-dosed EDP1815 in mild and moderate psoriasis.
[Evelo Biosciences, Inc.] |
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| NeoImmuneTech, Inc. announced that the first patient has been dosed in the Phase IIa portion of a study evaluating NT-I7 in combination with the PD-L1 targeting drug atezolizumab, in patients with advanced high-risk skin cancers including melanoma, merkel cell carcinoma, and cutaneous squamous cell carcinoma.
[NeoImmuneTech, Inc. (Businesswire, Inc.)] |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | University of California Los Angeles – Los Angeles, California, United States |
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| | Howard Hughes Medical Institute – Dallas, Texas, United States |
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