Dermal Cell News Volume 8.06 | Feb 28 2022

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    2022-02-28 | DCN 8.06


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.06 – 28 February, 2022
    TOP STORY

    Dermal αSMA+ Myofibroblasts Orchestrate Skin Wound Repair via β1 Integrin and Independent of Type I Collagen Production

    Researchers demonstrated that genetic depletion of αSMA+ myofibroblasts led to pleiotropic wound healing defects, including lack of reepithelialization, dampened angiogenesis, and heightened hypoxia.
    [EMBO Journal]

    AbstractGraphical Abstract
    ON987CXN-mar-728x90-2022
    PUBLICATIONSRanked by the impact factor of the journal

    Thymic Stromal Lymphopoietin Controls Hair Growth

    The authors demonstrated that thymic stromal lymphopoietin was produced in response to skin injury and during the anagen phase of the hair cycle.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Tofacitinib and Metformin Reduce the Dermal Thickness and Fibrosis in Mouse Model of Systemic Sclerosis

    Researchers investigated the therapeutic efficacy of tofacitinib and metformin on IL-17 and transforming growth factor beta cytokines, skin fibrosis and inflammation in mouse model of systemic sclerosis.
    [Scientific Reports]

    Full Article

    Spatiotemporal Dynamics of PIEZO1 Localization Controls Keratinocyte Migration during Wound Healing

    Investigators showed through molecular, cellular and organismal studies that the mechanically-activated ion channel PIEZO1 regulated keratinocyte migration and wound healing.
    [Biophysical Journal]

    Abstract

    Antimicrobial Production by Perifollicular Dermal Preadipocytes Is Essential to the Pathophysiology of Acne

    Scientists investigated the potential role of adipogenesis by dermal fibroblasts in acne and performed single-cell RNA sequencing on human acne lesions and mouse skin challenged by Cutibacterium acnes.
    [Science Translational Medicine]

    Full ArticlePress Release

    The Histone Demethylase PHF8 Regulates TGFβ Signaling and Promotes Melanoma Metastasis

    Loss- and gain-of-function approaches demonstrated that plant homeodomain finger protein 8 (PHF8) promoted cell invasion without affecting proliferation in vitro and increased dissemination.
    [Science Advances]

    Full Article

    Oxeiptosis: A Novel Pathway of Melanocytes Death in Response to Oxidative Stress in Vitiligo

    Researchers found that other cell death modalities may exist in addition to the well-recognized apoptosis and necroptosis in H2O2-treated melanocytes.
    [Cell Death Discovery]

    Full Article

    PLP2-Derived Peptide Rb4 Triggers PARP-1-Mediated Necrotic Death in Murine Melanoma Cells

    Investigators studied the antitumor activity of peptide Rb4 derived from Proteolipid protein 2 (PLP2). In vitro Rb4 induced F-actin polymerization, prevented F-actin depolymerization and increased the ER-derived cytosolic calcium.
    [Scientific Reports]

    Full Article

    Hotspot Analysis by Confocal Microscopy Can Help to Differentiate Challenging Melanocytic Skin Lesions

    Scientists conducted a study which included 110 melanocytic lesions and three confocal features that were statistically able to distinguish benign melanocytic lesions from melanomas.
    [PLoS One]

    Full Article
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    REVIEWS

    Single-Cell Transcriptomics in Human Skin Research: Available Technologies, Technical Considerations, and Disease Applications

    The authors discuss the available technologies and technical considerations of single-cell RNA sequencing and describes its applications to a broad spectrum of dermatological diseases.
    [Experimental Dermatology]

    AbstractFull Article

    Autophagy and Skin Wound Healing

    Understanding the relationship between autophagy and skin wound healing may provide novel strategies for the clinical treatment of wound healing.
    [Burns & Trauma]

    Full Article
    INDUSTRY AND POLICY NEWS

    TGen Partners with Deepcell to Advance Detection, Analysis and Treatment of Disease

    The Translational Genomics Research Institute (TGen) has partnered with Deepcell, Inc. to become one of the first research institutes in the world to employ a new artificial intelligence-powered imaging and sorting technology to classify and isolate individual diseased cells.
    [Translational Genomics Research Institute]

    Press Release

    Durable and Deepening Clinical Responses Observed in Post-Treatment Period of Evelo Bioscience’s Phase II Clinical Trial of Oral EDP1815 in Psoriasis

    Evelo Biosciences, Inc. announced data from the post-treatment follow-up of its Phase II trial of EDP1815 in mild and moderate psoriasis including durable and deeper clinical responses.
    [Evelo Biosciences, Inc.]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2022

    2022-04-08-2022-04-13 |

    New Orleans, Louisiana, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Skin Equivalents and Skin Cell Biology

    Durham University – Durham, England, United Kingdom

    Postdoctoral Positions – Translational 3D Pathology

    University of Washington – Seattle, Washington, United States

    Postdoctoral Researcher – 3D Advanced Microscopy

    IRB Barcelona – Barcelona, Spain

    Postdoctoral Research Fellow – Tumor Metabolism

    Wayne State University School of Medicine – Detroit, Michigan, United States

    Postdoctoral Fellow – Mammalian Skin Regeneration

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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