| Vol. 8.06 – 28 February, 2022 |
| |
|
|
| Researchers demonstrated that genetic depletion of αSMA+ myofibroblasts led to pleiotropic wound healing defects, including lack of reepithelialization, dampened angiogenesis, and heightened hypoxia. [EMBO Journal] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
|
|
|
| The authors demonstrated that thymic stromal lymphopoietin was produced in response to skin injury and during the anagen phase of the hair cycle. [Stem Cell Reports] |
|
|
|
| Researchers investigated the therapeutic efficacy of tofacitinib and metformin on IL-17 and transforming growth factor beta cytokines, skin fibrosis and inflammation in mouse model of systemic sclerosis. [Scientific Reports] |
|
|
|
| Investigators showed through molecular, cellular and organismal studies that the mechanically-activated ion channel PIEZO1 regulated keratinocyte migration and wound healing. [Biophysical Journal] |
| |
|
|
| Scientists investigated the potential role of adipogenesis by dermal fibroblasts in acne and performed single-cell RNA sequencing on human acne lesions and mouse skin challenged by Cutibacterium acnes. [Science Translational Medicine] |
|
|
|
| Loss- and gain-of-function approaches demonstrated that plant homeodomain finger protein 8 (PHF8) promoted cell invasion without affecting proliferation in vitro and increased dissemination. [Science Advances] |
|
|
|
| Researchers found that other cell death modalities may exist in addition to the well-recognized apoptosis and necroptosis in H2O2-treated melanocytes. [Cell Death Discovery] |
|
|
|
| Investigators studied the antitumor activity of peptide Rb4 derived from Proteolipid protein 2 (PLP2). In vitro Rb4 induced F-actin polymerization, prevented F-actin depolymerization and increased the ER-derived cytosolic calcium. [Scientific Reports] |
|
|
|
| Scientists conducted a study which included 110 melanocytic lesions and three confocal features that were statistically able to distinguish benign melanocytic lesions from melanomas. [PLoS One] |
|
|
|
|
| The authors discuss the available technologies and technical considerations of single-cell RNA sequencing and describes its applications to a broad spectrum of dermatological diseases. [Experimental Dermatology] |
|
|
|
|
Understanding the relationship between autophagy and skin wound healing may provide novel strategies for the clinical treatment of wound healing. [Burns & Trauma] |
| |
|
|
| The Translational Genomics Research Institute (TGen) has partnered with Deepcell, Inc. to become one of the first research institutes in the world to employ a new artificial intelligence-powered imaging and sorting technology to classify and isolate individual diseased cells. [Translational Genomics Research Institute] |
|
|
|
| Evelo Biosciences, Inc. announced data from the post-treatment follow-up of its Phase II trial of EDP1815 in mild and moderate psoriasis including durable and deeper clinical responses. [Evelo Biosciences, Inc.] |
|
|
|
|
| New Orleans, Louisiana, United States |
|
|
|
|
|
| Durham University – Durham, England, United Kingdom |
|
|
|
| University of Washington – Seattle, Washington, United States |
|
|
|
| IRB Barcelona – Barcelona, Spain |
|
|
|
| Wayne State University School of Medicine – Detroit, Michigan, United States |
|
|
|
| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
|
|
|
|