| Vol. 8.08 – 14 March, 2022 |
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| Researchers demonstrated that the beta-human papillomavirus 49 wild-type genome was transcriptionally active in normal human keratinocytes but lacked immortalizing activity unless the E8 gene was inactivated. [Proceedings of the National Academy of Sciences of the United States of America] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| Investigators showed that miR-378a was induced by IL-17A in keratinocytes through NF-κB, C/EBP-β and IκBζ, and was overexpressed in psoriasis epidermis. [British Journal of Dermatology] |
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| Scientists identified a high expression of miRNA-181a-5p in the low-passage exosomes derived from dermal papilla cell (DPC-Exos), revealing the transportation patterns of the DPC-Exos-derived miRNA-181a-5p entering the hair follicle stem cell. [International Journal of Biological Macromolecules] |
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| Researchers found that blue light-induced oxidative stress triggered the endoplasmic reticulum stress-C/EBP homologous protein signal and affected the protein levels of B-cell lymphoma-2 (Bcl-2) and Bcl2-associated X, thereby promoting apoptosis. [Journal of Photochemistry and Photobiology B-Biology] |
| | Investigators revealed that PLA2G6 was up-regulated in cutaneous malignant melanoma tissues compared to nevus tissues, as well as increased in vitro in SK-MEL-28 and M14 melanoma cell lines compared to human melanocytes. [Frontiers in Oncology] |
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| The authors reported that nobiletin, a natural product isolated from citrus peel, exhibited antitumor activity by inducing ferroptosis in melanoma cells. [Frontiers in Genetics] |
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| Researchers evaluated cell viability, apoptosis rate, and reactive species injection efficiency of melanoma cells and human keratinocyte cells treated with cold atmospheric plasma and analyzed its biological safety. [Journal of Biophotonics] |
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| LINC01063 knockdown impeded melanoma cell proliferation, migration, invasion, and epithelial-mesenchymal transition as well as melanoma tumor growth. [Melanoma Research] |
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| Scientists investigated the structural and functional changes in the localized scleroderma (LSc) epidermis and further explored the underlying mechanisms, providing a new angle to treat LSc in the clinic. [Clinical Rheumatology] |
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| The authors describe the most recent progress on post-translational modifications, and their regulative factors in the context of Merkel cell carcinoma (MCC) onset/development, providing an overview of current findings on both MCC subtypes. [Frontiers in Oncology] |
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| Investigators summarize the key features of psoriasis and atopic dermatitis, the different types of in vitro models available to study their pathophysiology and evaluate their efficacy in addition to discussing future research opportunities. [Frontiers in Bioengineering and Biotechnology] |
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| Abeona Therapeutics, Inc. announced that target enrollment has been achieved in its pivotal Phase III VIITAL™ study. The objective of VIITAL™ is to evaluate the safety and effectiveness of Abeona’s investigational EB-101 product for the treatment of recessive dystrophic epidermolysis bullosa (RDEB). [Abeona Therapeutics Inc.] |
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| Biofrontera, Inc. announced that the previously granted US patent No. 11,235,169 for the BF-RhodoLED® XL illumination device is now listed in the FDA publication “Approved Drug Products with Therapeutic Equivalence Evaluations,” commonly known as the Orange Book. [Biofrontera Inc.] |
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| May 9 – 12, 2022 Montreal, Quebec, Canada |
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| Columbia University Medical Center – New York, NY, United States |
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| Berlin Institute of Health – Berlin, Germany |
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| Technical University of Denmark – Lyngby, Denmark |
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| King’s College London – London, England, United Kingdom |
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| Lee Kong Chian School of Medicine – Singapore, Singapore |
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