Dermal Cell News Volume 8.08 | Mar 14 2022

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    2022-03-14 | DCN 8.08


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.08 – 14 March, 2022
    TOP STORY

    Restriction of Viral Gene Expression and Replication Prevents Immortalization of Human Keratinocytes by a Beta-Human Papillomavirus

    Researchers demonstrated that the beta-human papillomavirus 49 wild-type genome was transcriptionally active in normal human keratinocytes but lacked immortalizing activity unless the E8 gene was inactivated.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article
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    MiR-378a Regulates Keratinocyte Responsiveness to IL-17A in Psoriasis

    Investigators showed that miR-378a was induced by IL-17A in keratinocytes through NF-κB, C/EBP-β and IκBζ, and was overexpressed in psoriasis epidermis.
    [British Journal of Dermatology]

    AbstractFull Article

    Exosomal MiRNA-181a-5p from the Cells of the Hair Follicle Dermal Papilla Promotes the Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway

    Scientists identified a high expression of miRNA-181a-5p in the low-passage exosomes derived from dermal papilla cell (DPC-Exos), revealing the transportation patterns of the DPC-Exos-derived miRNA-181a-5p entering the hair follicle stem cell.
    [International Journal of Biological Macromolecules]

    Abstract

    Blue Light Induces Skin Apoptosis and Degeneration through Activation of the Endoplasmic Reticulum Stress-Autophagy Apoptosis Axis: Protective Role of Hydrogen Sulfide

    Researchers found that blue light-induced oxidative stress triggered the endoplasmic reticulum stress-C/EBP homologous protein signal and affected the protein levels of B-cell lymphoma-2 (Bcl-2) and Bcl2-associated X, thereby promoting apoptosis.
    [Journal of Photochemistry and Photobiology B-Biology]

    Abstract

    PLA2G6 Silencing Suppresses Melanoma Progression and Affects Ferroptosis Revealed by Quantitative Proteomics

    Investigators revealed that PLA2G6 was up-regulated in cutaneous malignant melanoma tissues compared to nevus tissues, as well as increased in vitro in SK-MEL-28 and M14 melanoma cell lines compared to human melanocytes.
    [Frontiers in Oncology]

    Full Article

    Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signaling Pathway

    The authors reported that nobiletin, a natural product isolated from citrus peel, exhibited antitumor activity by inducing ferroptosis in melanoma cells.
    [Frontiers in Genetics]

    Full Article

    Biosafety and Differentially Expressed Genes Analysis of Melanoma Cells Treated with Cold Atmospheric Plasma

    Researchers evaluated cell viability, apoptosis rate, and reactive species injection efficiency of melanoma cells and human keratinocyte cells treated with cold atmospheric plasma and analyzed its biological safety.
    [Journal of Biophotonics]

    Abstract

    LINC01063 Functions as an Oncogene in Melanoma through Regulation of MiR-5194-Mediated SOX12 Expression

    LINC01063 knockdown impeded melanoma cell proliferation, migration, invasion, and epithelial-mesenchymal transition as well as melanoma tumor growth.
    [Melanoma Research]

    Abstract

    Abnormal Expression of Interleukin-6 Is Associated with Epidermal Alternations in Localized Scleroderma

    Scientists investigated the structural and functional changes in the localized scleroderma (LSc) epidermis and further explored the underlying mechanisms, providing a new angle to treat LSc in the clinic.
    [Clinical Rheumatology]

    Abstract
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    REVIEWS

    The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma

    The authors describe the most recent progress on post-translational modifications, and their regulative factors in the context of Merkel cell carcinoma (MCC) onset/development, providing an overview of current findings on both MCC subtypes.
    [Frontiers in Oncology]

    Full Article

    In Vitro Disease Models for Understanding Psoriasis and Atopic Dermatitis

    Investigators summarize the key features of psoriasis and atopic dermatitis, the different types of in vitro models available to study their pathophysiology and evaluate their efficacy in addition to discussing future research opportunities.
    [Frontiers in Bioengineering and Biotechnology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Abeona Therapeutics Achieves Target Enrollment in Pivotal Phase III VIITAL Study of EB-101 in RDEB

    Abeona Therapeutics, Inc. announced that target enrollment has been achieved in its pivotal Phase III VIITAL study. The objective of VIITAL is to evaluate the safety and effectiveness of Abeona’s investigational EB-101 product for the treatment of recessive dystrophic epidermolysis bullosa (RDEB).
    [Abeona Therapeutics Inc.]

    Press Release

    Biofrontera Inc. Announces FDA Orange Book Listing of U.S. Patent for BF-RhodoLED® XL, Extends Protection of Ameluz®-PDT Through October 2040

    Biofrontera, Inc. announced that the previously granted US patent No. 11,235,169 for the BF-RhodoLED® XL illumination device is now listed in the FDA publication “Approved Drug Products with Therapeutic Equivalence Evaluations,” commonly known as the Orange Book.
    [Biofrontera Inc.]

    Press Release
    FEATURED EVENT

    AACR Conference: Sarcomas

    May 9 – 12, 2022
    Montreal, Quebec, Canada

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    JOB OPPORTUNITIES

    Postdoctoral Research – Multimodal omics

    Columbia University Medical Center – New York, NY, United States

    Postdoctoral Researcher – Bioengineering Human Disease Models

    Berlin Institute of Health – Berlin, Germany

    Postdoctoral Researcher – Skin Barrier Function

    Technical University of Denmark – Lyngby, Denmark

    Research Assistant – Stem Cells and Regenerative Medicine

    King’s College London – London, England, United Kingdom

    Assistant Professor – Skin Immunology

    Lee Kong Chian School of Medicine – Singapore, Singapore

    > See All Jobs

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