Dermal Cell News Volume 8.10 | Mar 28 2022

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    Justin.choi
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    2022-03-28 | DCN 8.10


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.10 – 28 March, 2022
    TOP STORY

    A Dual-Cross-Linked Hydrogel Patch for Promoting Diabetic Wound Healing

    A hemostatic and anti-inflammatory hydrogel patch was designed for promoting diabetic wound healing, derived from dual-cross-linked methacryloyl-substituted Bletilla Striata polysaccharide and gelatin via ultraviolet light.
    [Small]

    Abstract
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Reconstructed Human Pigmented Skin/Epidermis Models Achieve Epidermal Pigmentation through Melanocore Transfer

    Scientists performed histology and immunohistochemistry analyses and demonstrated that a newly developed full-thickness 3D reconstructed human pigmented skin model and an epidermis-only model exhibit dispersed pigment throughout keratinocytes in the epidermis.
    [Pigment Cell & Melanoma Research]

    Abstract

    Olfactomedin 4 Regulates Migration and Proliferation of Immortalized Non-Transformed Keratinocytes through Modulation of the Cell Cycle Machinery and Actin Cytoskeleton Remodeling

    Researchers studied the outcomes of olfactomedin 4 downregulation in human immortalized keratinocytes – the HaCaT cells.
    [Experimental Cell Research]

    Full Article

    Ultraviolet Light Induces HERV Expression to Activate RIG-I Signaling Pathway in Keratinocytes

    UVB-induced human endogenous retrovirus (HERV)-associated double-stranded RNA transcription and subsequent activation of the innate antiviral retinoic acid-inducible gene I(RIG-I)/MDA5/IRF7 pathway led to downstream transcription of interferon-stimulated genes.
    [Experimental Dermatology]

    Abstract

    Discoidin Domain Receptor 2 Orchestrates Melanoma Resistance Combining Phenotype Switching and Proliferation

    Scientists showed that a majority of human melanoma overexpressed discoidin domain receptor 2 after treatment. The same results were found in resistant cell lines presenting phenotype switching compared to the corresponding sensitive cell lines.
    [Oncogene]

    Abstract

    A Multifunctional Composite Hydrogel as an Intrinsic and Extrinsic Coregulator for Enhanced Therapeutic Efficacy for Psoriasis

    A nanocomposite-based hydrogel was constructed by loading methotrexate into zinc oxide/silver to realize combined multiple target therapy of psoriasis.
    [Journal of Nanobiotechnology]

    Full Article

    C-Phycocyanin Decreases Proliferation and Migration of Melanoma Cells: In Silico and In Vitro Evidences

    Investigators evaluated the ability of pigment C-phycocyanin to bind to the main cellular targets related in the progression of melanoma through molecular docking, and the reflection of this bind in the biological effects in the B16F10 cell line through in vitro analysis.
    [Bioorganic Chemistry]

    AbstractGraphical Abstract

    Novel Chloroquine Derivative Suppresses Melanoma Cell Growth by DNA Damage through Increasing ROS Levels

    Researchers found a novel chloroquine derivative, lj-2-66, that increased the level of reactive oxygen species (ROS) in melanoma cells and induced DNA damage, thus leading to G2/M arrest and apoptosis.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    AXL Inhibition Improves BRAF-Targeted Treatment in Melanoma

    The authors investigated the therapeutic potential of the AXL inhibitor BGB324 alone or in combination with the clinically relevant BRAF inhibitor vemurafenib.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Emerging Precision Diagnostics in Advanced Cutaneous Squamous Cell Carcinoma

    Investigators highlight new insights into the mutational profile of cutaneous squamous cell carcinoma, summarize current diagnostic and therapeutic standards, and discuss emerging diagnostic approaches.
    [npj Precision Oncology]

    Full Article

    Dermal Extracellular Matrix Molecules in Skin Development, Homeostasis, Wound Regeneration and Diseases

    The authors describe the plasticity of dermal fibroblasts (dFBs) during development and wound healing and how various dFB-derived extracellular matrix (ECM) molecules are expressed and regulated, and in turn how these ECM molecules play a role in regulating the function of dFBs and immune cells.
    [Seminars in Cell & Developmental Biology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Janssen Initiates First-of-its-Kind Clinical Study to Bridge Critical Gaps in Care for People of Color with Moderate to Severe Plaque Psoriasis

    The Janssen Pharmaceutical Companies of Johnson & Johnson announced the initiation of VISIBLE, a first-of-its-kind, large-scale prospective clinical study dedicated to people of color living with moderate to severe plaque and/or scalp psoriasis.
    [Johnson & Johnson]

    Press Release

    Kane Biotech Successfully Completes Safety and Biocompatibility Studies for DispersinB® Wound Gel in Preparation for Human Clinical Trials

    Kane Biotech, Inc. announced positive results from biocompatibility and in vivo safety studies in preparation for human clinical trials set to begin later this year.
    [Kane Biotech, Inc.]

    Press Release
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    JOB OPPORTUNITIES

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    In4Derm Ltd – Dundee, Scotland, United Kingdom

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    Wellcome Sanger Institute – Cambridge, England, United Kingdom

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    University of Southern Denmark – Odense M, Denmark

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    Columbia University Medical Center – New York, NY, United States

    Postdoctoral Researcher – Bioengineering Human Disease Models

    Berlin Institute of Health – Berlin, Germany

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