Dermal Cell News Volume 8.12 | Apr 11 2022

May 12, 2022

2022-04-11 | DCN 8.12

Dermal Cell News by STEMCELL Technologies

Vol. 8.12 – 11 April, 2022

TOP STORY

STAG2 Regulates Interferon Signaling in Melanoma via Enhancer Loop Reprogramming

Scientists showed that depletion of stromal antigen 2 (STAG2) in melanoma cells led to the expansion of topologically associating domains and enhanced the formation of acetylated histone H3 lysine 27-associated DNA loops.
[Nature Communications]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

DERMAL STEM CELLS & TISSUE REGENERATION

Superoxide Anion Radical Induced Phototoxicity of 2,4, 5,6-Tetraminopyrimidine Sulfate via Mitochondrial-Mediated Apoptosis in Human Skin Keratinocytes at Ambient UVR Exposure

Researchers studied the photosensitization potential and mechanism involved in dermal phototoxicity of 2,4,5,6-tetraaminopyrimidine sulfate exposed to the dark and UVA/UVB/sunlight by using different in-chemico and mammalian cells, as test systems.
[Food and Chemical Toxicology]

Abstract Graphical Abstract

Altered Regulation of Mesenchymal Cell Senescence in Adipose Tissue Promotes Pathological Changes Associated with Diabetic Wound Healing

Investigators showed that the number of p15^INK4B + PDGFRα + senescent mesenchymal cells in adipose tissue increased transiently during the early phases of wound healing in both non-diabetic mice and humans.
[Communications Biology]

Full Article

Parental Uveitis Causes Elevated Hair Loss in Offspring of C57BL/6J Mice

Histopathological observation of samples showed increased melanin granules and hair follicles of skin in the affected offspring with hair loss.
[Experimental Eye Research]

Abstract

Comparison between Injectable Platelet-Rich Fibrin and Platelet-Rich Plasma in Ameliorating UVA-Induced Photoaging in Human Dermal Fibroblasts via the Activation of TGF-β/Smad Signaling Pathway

Scientists compared the anti-photoaging effects of injectable platelet-rich fibrin in UVA-irradiated human dermal fibroblasts with those of platelet-rich plasma by examining cell proliferation, migration, apoptosis, ROS generation, matrix metalloproteinase and collagen I levels.
[Photochemistry and Photobiology]

Abstract

SKIN CANCERS & DISORDERS

Aging-Conferred SIRT7 Decline Inhibits Rosacea-Like Skin Inflammation via Modulating TLR2-NF-κB Signaling

Investigators confirmed that the rosacea-like skin inflammation induced by Cathelicidin LL37 was alleviated in aged mice and mice with progeria.
[Journal of Investigative Dermatology]

Abstract

Topical Heparin as an Effective and Safe Treatment for Patients with Capecitabine-Induced Hand-Foot Syndrome: Results of a Phase IIA Trial Supported by Proteomic Profiling of Skin Biopsies

The authors evaluated the safety and effectiveness of a topical heparin treatment on the clinical manifestations and anatomopathological alterations of capecitabine-induced hand-foot syndrome.
[Therapeutic Advances in Medical Oncology]

Full Article

A Noncoding Regulatory RNA Gm31932 Induces Cell Cycle Arrest and Differentiation in Melanoma via the MiR-344d-3-5p/Prc1 (and Nuf2) Axis

Integrative analysis of whole transcriptome sequencing data demonstrated that lncRNA-Gm31932 was significantly decreased in all-trans retinoic acid-induced and sodium 4-phenylbutanoate-induced mouse melanoma B16 cells.
[Cell Death & Disease]

Full Article

Low-Metastatic Melanoma Cells Acquire Enhanced Metastatic Capability via Exosomal Transfer of MiR-199a-1-5p from Highly Metastatic Melanoma Cells

Scientists showed that exosomal crosstalk between metastatic cancer cells was a new mechanism that underlied cancer metastasis and heterogeneity.
[Cell Death Discovery]

Full Article

Novel Therapeutic Strategy for Melanoma Based on Albendazole and the CDK4/6 Inhibitor Palbociclib

Researchers demonstrated that albendazole, an FDA-approved broad-spectrum antiparasitic agent, significantly inhibited the proliferation of melanoma cells in vitro and in vivo.
[Scientific Reports]

Full Article

High Melanin Content in Melanoma Cells Contributes to Enhanced DNA Damage after Rose Bengal Photosensitization

Investigators examine DNA damage in melanoma cells with different melanin contents, subjected to O₂ generation and used the photosensitizer Rose Bengal acetate and irradiation with visible light.
[Photochemistry and Photobiology]

Abstract

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REVIEWS

The Crucial Roles of M⁶A RNA Modifications in Cutaneous Cancers: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies

The authors summarize the biological characteristics of m⁶A modification, its regulatory role and mechanism in skin cancers, and the recent research progress of m⁶A-related molecular drugs.
[Genes & Diseases]

Abstract

INDUSTRY AND POLICY NEWS

VYNE Therapeutics Announces Positive Phase Ib Efficacy Data for FMX114 from Phase Ib/IIa Trial for the Treatment of Mild-to-Moderate Atopic Dermatitis

VYNE Therapeutics Inc. announced positive efficacy results from the Phase Ib segment of a Phase Ib/IIa clinical trial evaluating FMX114 for the treatment of mild-to-moderate atopic dermatitis.
[VYNE Therapeutics Inc.]

Press Release

Can-Fite is Developing a Topical Piclidenoson Psoriasis Treatment that Shows Efficacy in a Preclinical Model: Potential Complementary Product to its Phase III Oral Psoriasis Drug

Can-Fite BioPharma Ltd. announced it is developing a topical psoriasis treatment with Piclidenoson, its Phase III psoriasis oral drug candidate.
[Can-Fite BioPharma Ltd.]

Press Release

FEATURED EVENT

STAG2 Regulates Interferon Signaling in Melanoma via Enhancer Loop Reprogramming

Superoxide Anion Radical Induced Phototoxicity of 2,4, 5,6-Tetraminopyrimidine Sulfate via Mitochondrial-Mediated Apoptosis in Human Skin Keratinocytes at Ambient UVR Exposure

Altered Regulation of Mesenchymal Cell Senescence in Adipose Tissue Promotes Pathological Changes Associated with Diabetic Wound Healing

Parental Uveitis Causes Elevated Hair Loss in Offspring of C57BL/6J Mice

Comparison between Injectable Platelet-Rich Fibrin and Platelet-Rich Plasma in Ameliorating UVA-Induced Photoaging in Human Dermal Fibroblasts via the Activation of TGF-β/Smad Signaling Pathway

Aging-Conferred SIRT7 Decline Inhibits Rosacea-Like Skin Inflammation via Modulating TLR2-NF-κB Signaling

Topical Heparin as an Effective and Safe Treatment for Patients with Capecitabine-Induced Hand-Foot Syndrome: Results of a Phase IIA Trial Supported by Proteomic Profiling of Skin Biopsies

A Noncoding Regulatory RNA Gm31932 Induces Cell Cycle Arrest and Differentiation in Melanoma via the MiR-344d-3-5p/Prc1 (and Nuf2) Axis

Low-Metastatic Melanoma Cells Acquire Enhanced Metastatic Capability via Exosomal Transfer of MiR-199a-1-5p from Highly Metastatic Melanoma Cells

Novel Therapeutic Strategy for Melanoma Based on Albendazole and the CDK4/6 Inhibitor Palbociclib

High Melanin Content in Melanoma Cells Contributes to Enhanced DNA Damage after Rose Bengal Photosensitization

The Crucial Roles of M⁶A RNA Modifications in Cutaneous Cancers: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies

VYNE Therapeutics Announces Positive Phase Ib Efficacy Data for FMX114 from Phase Ib/IIa Trial for the Treatment of Mild-to-Moderate Atopic Dermatitis

Can-Fite is Developing a Topical Piclidenoson Psoriasis Treatment that Shows Efficacy in a Preclinical Model: Potential Complementary Product to its Phase III Oral Psoriasis Drug

ISSCR 2022 Annual Meeting

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Postdoctoral Researcher – Molecular Tissue/Organ Regeneration

Advance Research Assistant – Cellular Generation & Phenotyping

Postdoctoral Fellowship – Dermatology

Senior Biologist – Skin Diseases

Postdoctoral Fellow – Melanoma/Glioblastoma Tumorigenesis

> See All Jobs