Dermal Cell News Volume 8.18 | May 30 2022

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    2022-05-30 | DCN 8.18


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.18 – 30 May, 2022
    TOP STORY

    Gibbin Mesodermal Regulation Patterns Epithelial Development

    Investigators identified the protein Gibbin, encoded by the Xia–Gibbs AT-hook DNA-binding-motif-containing 1 disease gene as a key regulator of early epithelial morphogenesis.
    [Nature]

    Abstract
    ON712CXN-Cancer-728-x-90-1
    PUBLICATIONSRanked by the impact factor of the journal

    Targeting SLC7A11 Improves Efferocytosis by Dendritic Cells and Wound Healing in Diabetes

    In a mouse model of excisional skin wounding, inhibition or loss of solute carrier family 7 member 11 (SLC7A11) expression accelerated healing dynamics and reduced the apoptotic cell load in the wound. Mechanistic studies revealed a link between SLC7A11, glucose homeostasis, and diabetes.
    [Nature]

    Abstract

    In Vitro and In Vivo Evaluations of Tocotrienol-Rich Nanoemulsified System on Skin Wound Healing

    Keratinocyte migration and zebrafish tail regeneration experiments were used to evaluate the wound healing effect of a tocotrienol-based nanoemulsified system against ascorbic acid and phosphate-buffered saline as positive and negative controls, respectively.
    [PLoS One]

    Full Article

    The Interferon-β/STAT1 Axis Drives the Collective Invasion of Skin Squamous Cell Carcinoma with Sealed Intercellular Spaces

    Investigators successfully established subclones with various invasive potentials derived from human skin squamous carcinoma cells.
    [Oncogenesis]

    Full Article

    Loss of YY1, a Regulator of Metabolism in Melanoma, Drives Melanoma Cell Invasiveness and Metastasis Formation

    The authors demonstrated that transcription factor Yin Yang 1 (YY1), while being essential for primary melanoma formation, suppressed metastatic spreading.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    eIF6 as a Promising Diagnostic and Prognostic Biomarker for Poorer Survival of Cutaneous Melanoma

    Researchers revealed that eukaryotic initiation factor 6 (eIF6) was highly over-expressed in melanomas compared to normal skin specimens, and thus the abnormally high level of eIF6 could be a diagnostic marker for melanoma.
    [Frontiers in Oncology]

    Full Article

    5-Aza-DC Suppresses Melanoma Progression by Inhibiting GAS5 Hypermethylation

    Analysis of the tumor suppressor gene growth arrest‑specific transcript 5 (GAS5) demonstrated that its expression was downregulated in melanoma, and its expression level had a certain negative association with its methylation modification level.
    [Oncology Reports]

    Abstract
    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    Microbiota and Maintenance of Skin Barrier Function

    The authors examine how microbiota-based mechanisms can be targeted to prevent or manage skin disorders and impaired wound healing.
    [Science]

    Abstract
    INDUSTRY AND POLICY NEWS

    RAPT Therapeutics Announces Initiation of Phase IIb Trial of RPT193 in Patients with Moderate-to-Severe Atopic Dermatitis

    RAPT Therapeutics, Inc. announced it has initiated its 16-week randomized, double-blind, placebo-controlled Phase IIb clinical trial to further evaluate the efficacy and safety of RPT193 as monotherapy in patients with moderate-to-severe atopic dermatitis.
    [RAPT Therapeutics, Inc.]

    Press Release

    FDA Approves Dermavant’s VTAMA® (tapinarof) Cream, 1% for the Treatment of Plaque Psoriasis in Adults: First Topical Novel Chemical Entity Launched for Psoriasis in the US in 25 Years

    Dermavant Sciences announced that the FDA has approved VTAMA® cream, 1%, an aryl hydrocarbon receptor agonist, indicated for the topical treatment of plaque psoriasis in adults.
    [Dermavant Sciences]

    Press Release

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    Oslo University Hospital – Oslo, Norway

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    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

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    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

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    GSK – Collegeville, Pennsylvania, United States

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