| Vol. 8.20 – 13 June, 2022 |
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Researchers generated eight conditional, knock-in mouse models and showed that rare melanoma mutants were poor drivers of spontaneous melanoma formation, whereas common melanoma mutants induced rapid tumor onset with high penetrance. [Nature Communications] |
| | PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| The authors reported an in vitro epidermis model using floating paper chips as a scaffold for the proliferation and differentiation of primary human keratinocytes. [Small] |
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| Scientists demonstrated persistence of nitric oxide release in a dark reaction after moderate ultraviolet-A (UV-A) exposure, peaking around 48 hours post-exposure; this effect was shown in keratinocytes, fibroblasts, and endothelial cells from neonatal donors and keratinocytes from aged donors. [Scientific Reports] |
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| Researchers reported that the differentiation of keratinocytes was dependent on the level of miR-203 expression and that inhibition of miR-203 could increase the expression of survivin, an epidermal marker of stemness. [Journal of Cosmetic Dermatology] |
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| Investigators fabricated a three-joint robotic finger covered with skin equivalent by developing a method to cover 3D objects with skin equivalent. [Matter] |
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| A mucosal melanoma cell line, MM9H-1, was established which exhibited robust proliferation and tumorigenicity after more than 100 serial passages. [Cancer Communications] |
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| Scientists assessed the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) on four different human melanoma cell lines by western blot and flow cytometry and determined its effect on cell viability in vitro by MTT assay. [Cancer Gene Therapy] |
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| Investigators defined the pharmacological effects of Isatis tinctoria L. on inflammatory reactions and skin hyperkeratosis, which are the main symptoms of atopic dermatitis, in vivo and in vitro. [Chinese Medicine] |
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| The authors demonstrate the roles of exosomes in inflammatory skin disorders, stem cell, and tumor biology through a comprehensive evaluation of the diagnostic, prognostic, and therapeutic perspectives. [Journal of Cosmetic Dermatology] |
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| The use restorative medicine and therapeutic cells such as fibroblasts has tremendous potential in the treatment of skin diseases and can be a new window for the treatment of diseases with no definitive treatment. [Aesthetic Plastic Surgery] |
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| ASLAN Pharmaceuticals announced that it has initiated a research collaboration with Dr. Shawn Kwatra and Dr. Madan Kwatra to investigate the unique role of the IL-13Rα1 subunit, distinct from the role of other pathway components, in Type 2-mediated inflammatory diseases, specifically atopic dermatitis. [ASLAN Pharmaceuticals] |
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| NTU Lee Kong Chian School of Medicine – Singapore, Singapore |
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| University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| University of Gothenburg – Gothenburg, Sweden |
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| Oslo University Hospital – Oslo, Norway |
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