Dermal Cell News Volume 8.20 | Jun 13 2022

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    2022-06-13 | DCN 8.20


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.20 – 13 June, 2022
    TOP STORY

    Enhanced BRAF Engagement by NRAS Mutants Capable of Promoting Melanoma Initiation

    Researchers generated eight conditional, knock-in mouse models and showed that rare melanoma mutants were poor drivers of spontaneous melanoma formation, whereas common melanoma mutants induced rapid tumor onset with high penetrance.
    [Nature Communications]

    Full Article
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    Micromotor-Assisted Keratinocytes Migration in a Floating Paper Chip

    The authors reported an in vitro epidermis model using floating paper chips as a scaffold for the proliferation and differentiation of primary human keratinocytes.
    [Small]

    Full Article

    Post-Exposure Persistence of Nitric Oxide Upregulation in Skin Cells Irradiated by UV-A

    Scientists demonstrated persistence of nitric oxide release in a dark reaction after moderate ultraviolet-A (UV-A) exposure, peaking around 48 hours post-exposure; this effect was shown in keratinocytes, fibroblasts, and endothelial cells from neonatal donors and keratinocytes from aged donors.
    [Scientific Reports]

    Full Article

    MiR-203 Represses Keratinocyte Stemness by Targeting Survivin

    Researchers reported that the differentiation of keratinocytes was dependent on the level of miR-203 expression and that inhibition of miR-203 could increase the expression of survivin, an epidermal marker of stemness.
    [Journal of Cosmetic Dermatology]

    Abstract

    Living Skin on a Robot

    Investigators fabricated a three-joint robotic finger covered with skin equivalent by developing a method to cover 3D objects with skin equivalent.
    [Matter]

    Full ArticleGraphical AbstractPress Release

    Candidate Therapeutic Agents in a Newly Established Triple Wild-Type Mucosal Melanoma Cell Line

    A mucosal melanoma cell line, MM9H-1, was established which exhibited robust proliferation and tumorigenicity after more than 100 serial passages.
    [Cancer Communications]

    Full Article

    Activation of CEACAM1 with an Agonistic Monoclonal Antibody Results in Inhibition of Melanoma Cells

    Scientists assessed the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) on four different human melanoma cell lines by western blot and flow cytometry and determined its effect on cell viability in vitro by MTT assay.
    [Cancer Gene Therapy]

    Abstract

    Inhibitory Effect of Isatis tinctoria L. Water Extract on DNCB-Induced Atopic Dermatitis in BALB/C Mice and HaCaT Cells

    Investigators defined the pharmacological effects of Isatis tinctoria L. on inflammatory reactions and skin hyperkeratosis, which are the main symptoms of atopic dermatitis, in vivo and in vitro.
    [Chinese Medicine]

    Full Article
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    REVIEWS

    The Role of Exosomes in Skin Diseases

    The authors demonstrate the roles of exosomes in inflammatory skin disorders, stem cell, and tumor biology through a comprehensive evaluation of the diagnostic, prognostic, and therapeutic perspectives.
    [Journal of Cosmetic Dermatology]

    Abstract

    Role of Cultured Skin Fibroblasts in Regenerative Dermatology

    The use restorative medicine and therapeutic cells such as fibroblasts has tremendous potential in the treatment of skin diseases and can be a new window for the treatment of diseases with no definitive treatment.
    [Aesthetic Plastic Surgery]

    Abstract
    INDUSTRY AND POLICY NEWS

    ASLAN Pharmaceuticals Initiates Scientific Collaboration to Investigate the Distinct Role of IL-13 Receptor Signaling in Atopic Dermatitis

    ASLAN Pharmaceuticals announced that it has initiated a research collaboration with Dr. Shawn Kwatra and Dr. Madan Kwatra to investigate the unique role of the IL-13Rα1 subunit, distinct from the role of other pathway components, in Type 2-mediated inflammatory diseases, specifically atopic dermatitis.
    [ASLAN Pharmaceuticals]

    Press Release
    FEATURED EVENT

    3D Cell Culture Symposium

    December 1, 2022
    Virtual

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    JOB OPPORTUNITIES

    Research Fellows – Computational Biology

    NTU Lee Kong Chian School of Medicine – Singapore, Singapore

    Research Scientist – Melanoma Medical Oncology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Research Assistant – Melanoma Medical Oncology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Computational Genomics of UV-Induced DNA Damage

    University of Gothenburg – Gothenburg, Sweden

    Group Leader – Department of Molecular Biology

    Oslo University Hospital – Oslo, Norway

    > See All Jobs

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