Dermal Cell News Volume 8.21 | Jun 20 2022

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    2022-06-20 | DCN 8.21


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.21 – 20 June, 2022
    TOP STORY

    Bioprinting of Hair Follicle Germs for Hair Regenerative Medicine

    Scientists proposed an approach for the scalable and automated preparation of highly hair-inductive tissue grafts using a bioprinter.
    [Acta Biomaterialia]

    Full ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Activin B-Activated Cdc42 Signaling Plays a Key Role in Regulating Adipose-Derived Mesenchymal Stem Cells-Mediated Skin Wound Healing

    The dominant-negative mutant of Cdc42 was used to explore the role of Cdc42 in activin B-induced adipose-derived mesenchymal stem cell migration, proliferation, and secretion in vitro.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    UVB Drives Metabolic Rewiring and Epigenetic Reprograming and Protection by Sulforaphane in Human Skin Keratinocytes

    Investigators studied the metabolome, epigenome, and transcriptome of human keratinocytes exposed to ultraviolet B (UVB) with or without sulforaphane using liquid chromatography–mass spectroscopy, DNA methylation sequencing, and RNA sequencing.
    [Chemical Research in Toxicology]

    AbstractGraphical Abstract

    Sprouty1 Exerts a Preventive Effect on the Initiation of Psoriasis by Inhibiting Innate Immune Antimicrobial Peptide Cathelicidin and Immunocytes

    Human psoriasis skin and primary human keratinocyte were detected in vitro. Epidermis specific transgenic mouse strain was used to further investigate psoriasis-like skin inflammation in vivo.
    [Cell Proliferation]

    Full Article

    Integrated Analysis Reveals the Pivotal Interactions between Immune Cells in the Melanoma Tumor Microenvironment

    Combined analysis of microarray data and single-cell RNA sequencing data revealed the key interactions between immune cells in the melanoma microenvironment.
    [Scientific Reports]

    Full Article

    Anti-Tumor Effect of IDF-11774, an Inhibitor of Hypoxia-Inducible Factor-1, on Melanoma

    The inhibitory effects of IDF-11774, an inhibitor of HIF-1α, on melanoma growth and metastasis were examined using cultured B16F10 mouse melanoma cells and nude mice transplanted with B16F10 melanoma cells in the presence or absence of CoCl2-induced hypoxia.
    [Biomolecules & therapeutics]

    Abstract

    A Novel 7-Hypoxia-Related Long Non-Coding RNA Signature Associated with Prognosis and Proliferation in Melanoma

    Researchers explored the potential relationship between melanoma and hypoxia‑related long non-coding RNAs and demonstrated that MIR205HG could promote melanoma cell proliferation partly via the canonical Wnt/β‑catenin signaling pathway.
    [Molecular Medicine Reports]

    Abstract

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    REVIEWS

    Research Progress of Microneedles in the Treatment of Melanoma

    The authors introduce an update on the progress of microneedles (MNs) as an innovative strategy for melanoma, especially when combining MNs with different therapies against melanoma.
    [Journal of Controlled Release]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    FDA Approves First Systemic Treatment for Alopecia Areata

    The US FSA approved Olumiant oral tablets to treat adult patients with severe alopecia areata, marking the first FDA approval of a systemic treatment for alopecia areata.
    [FDA]

    Press Release

    VYNE Therapeutics Completes Enrollment in Phase IIa Trial of FMX114 for the Treatment of Mild-to-Moderate Atopic Dermatitis

    VYNE Therapeutics, announced the completion of enrollment in the Phase IIa study of FMX114 for the treatment of mild-to-moderate atopic dermatitis.
    [VYNE Therapeutics Inc.]

    Press Release
    FEATURED EVENT

    Advances in Therapeutic Applications of Stem Cells

    December 8 – 10, 2022
    Los Angeles, California, United States

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    JOB OPPORTUNITIES

    Associate Professor – Skin Cancer

    University College Dublin – Dublin, Ireland

    Postdoctoral Fellow – Interorgan Crosstalk

    Washington University School of Medicine – St. Louis, Missouri, United States

    Postdoctoral Research Scientist – Skin Cancer

    Columbia University – New York City, New York, United States

    Research Fellows – Computational Biologists

    NTU Lee Kong Chian School of Medicine – Singapore, Singapore

    Research Associate – Pluripotent Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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