| Vol. 8.22 – 27 June, 2022 |
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| By using hair follicles (HFs) to study regulatory T cell (Treg)-stem cell crosstalk, the authors showed an unrecognized function of the steroid hormone glucocorticoid in instructing skin-resident Tregs to facilitate HF stem-cell activation and HF regeneration. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| While intradermally injected vascular endothelial growth factor (VEGF)-loaded nanoparticles sufficed to induce a molecular rejuvenation signature in aged human skin on old mice, VEGF-A treatment also improved key aging parameters in isolated, organ-cultured aged human skin. [Science Advances] |
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| An in vitro wound healing model that mimicked re-epithelialization was established to examine the effect of cobalt protoporphyrin on the migratory capability of human keratinocytes in either normal glucose or high glucose media, as well as in the presence of either H2O2 or lipopolysaccharide. [Molecular Medicine] |
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| Researchers suggested that gel-like silver doped phosphate-based coacervates were promising multifunctional materials for smart wound dressings, being capable of simultaneously inhibiting pathogenic bacteria and maintaining good cell viability. [Scientific Reports] |
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| Scientists coupled dual acting inverted site array barcoding with single-cell RNA-seq to recover lineages and gene expression profiles from ∼47,000 human melanoma cells. [Molecular Cell] |
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| FRET-based biosensor screening revealed that cannabidiol elicited a sharp rise in cytosolic calcium, and activation of AMPK in human keratinocyte and neuroblastoma cell lines. [Molecular & Cellular Proteomics] |
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| The synergistic antiproliferative effect of TAP7f in combination with thapsigargin was studied in vitro in murine B16-F0 melanoma cells, and in human A375 and SB2 melanoma cells. [Journal of Cancer Research and Clinical Oncology] |
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| Lipopolysaccharide suppressed melanin synthesis, downregulated the expression of melanin synthesis-related proteins, and activated autophagy in vitiligo melanocytes. [Experimental Dermatology] |
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| Researchers found that the effects of soybean cell culture extract on alpha-melanocyte-stimulating hormone induced melanogenesis in B16-F10 murine melanoma cells. [Molecular Biology Reports] |
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| Scientists focus on the morphologic and immunohistochemical characteristics of the tumor microenvironment, and on the molecular determinants of resistance to immunotherapy, differentiating between inflamed and non-inflamed melanomas. [Seminars in Cancer Biology] |
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| The authors review the latest research advances in the field of hydrogels from a variety of natural tissue sources, including bone tissue, blood vessels, nerve tissue, adipose tissue, skin tissue, and muscle tissue, including preparation methods, advantages, and applications in tissue engineering, and regenerative medicine. [International Journal of Biological Macromolecules] |
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| Krystal Biotech, Inc. announced the submission of a Biologics License Application FDA seeking approval of B-VEC for the treatment of patients with dystrophic epidermolysis bullosa. [Krystal Biotech, Inc.] |
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| December 3 – 7, 2022 Washington, DC, United States |
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| Pennsylvania State University – State College, Pennsylvania, United States |
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| Washington University School of Medicine – St. Louis, Missouri, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University College Dublin – Dublin, Ireland |
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| Columbia University – New York City, New York, United States |
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