Dermal Cell News Volume 8.22 | Jun 27 2022

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    2022-06-27 | DCN 8.22


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.22 – 27 June, 2022
    TOP
    STORY

    Glucocorticoid Signaling and Regulatory T Cells Cooperate to Maintain the Hair-Follicle Stem-Cell
    Niche

    By using hair follicles (HFs) to study regulatory T cell (Treg)-stem cell crosstalk, the authors showed an unrecognized
    function of the steroid hormone glucocorticoid in instructing skin-resident Tregs to facilitate HF stem-cell activation and HF regeneration.
    [Nature Immunology]

    Abstract

    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal
    DERMAL STEM CELLS & TISSUE REGENERATION

    Human Organ Rejuvenation by VEGF-A: Lessons from the Skin

    While intradermally injected vascular endothelial growth factor (VEGF)-loaded nanoparticles sufficed to induce a molecular
    rejuvenation signature in aged human skin on old mice, VEGF-A treatment also improved key aging parameters in isolated, organ-cultured aged human skin.
    [Science Advances]

    Full Article

    Cobalt Protoporphyrin Promotes Human Keratinocyte Migration under Hyperglycemic
    Conditions

    An in vitro wound healing model that mimicked re-epithelialization was established to examine the effect of
    cobalt protoporphyrin on the migratory capability of human keratinocytes in either normal glucose or high glucose media, as well as in the presence of either H2O2 or lipopolysaccharide.
    [Molecular Medicine]

    Full Article

    Silver-Doped Phosphate Coacervates to Inhibit Pathogenic Bacteria Associated with Wound Infections:
    An In Vitro Study

    Researchers suggested that gel-like silver doped phosphate-based coacervates were promising multifunctional materials for
    smart wound dressings, being capable of simultaneously inhibiting pathogenic bacteria and maintaining good cell viability.
    [Scientific Reports]

    Full Article

    SKIN CANCERS & DISORDERS

    Machine-Learning-Optimized Cas12a Barcoding Enables the Recovery of Single-Cell
    Lineages and Transcriptional Profiles

    Scientists coupled dual acting inverted site array barcoding with single-cell RNA-seq to recover lineages and gene
    expression profiles from ∼47,000 human melanoma cells.
    [Molecular Cell]

    Full ArticleGraphical Abstract

    Multi-Omic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in
    Human Cell Lines

    FRET-based biosensor screening revealed that cannabidiol elicited a sharp rise in cytosolic calcium, and activation of
    AMPK in human keratinocyte and neuroblastoma cell lines.
    [Molecular & Cellular Proteomics]

    Full ArticleGraphical Abstract

    Synergistic Antitumor Effect of a Penicillin Derivative Combined with Thapsigargin in
    Melanoma Cells

    The synergistic antiproliferative effect of TAP7f in combination with thapsigargin was studied in vitro in murine
    B16-F0 melanoma cells, and in human A375 and SB2 melanoma cells.
    [Journal of Cancer Research and Clinical Oncology]

    Abstract

    Lipopolysaccharide Reduces Melanin Synthesis in Vitiligo Melanocytes by Regulating
    Autophagy

    Lipopolysaccharide suppressed melanin synthesis, downregulated the expression of melanin synthesis-related proteins, and
    activated autophagy in vitiligo melanocytes.
    [Experimental Dermatology]

    Abstract

    Inhibitory Activity of Soybean (Glycine max L. Merr.) Cell Culture Extract on Tyrosinase
    Activity and Melanin Formation in Alpha-Melanocyte Stimulating Hormone-Induced B16-F10 Melanoma Cells

    Researchers found that the effects of soybean cell culture extract on alpha-melanocyte-stimulating hormone induced
    melanogenesis in B16-F10 murine melanoma cells.
    [Molecular Biology Reports]

    Abstract

    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Targeting Inflamed and Non-Inflamed Melanomas: Biological Background
    and Clinical Challenges

    Scientists focus on the morphologic and immunohistochemical characteristics of the tumor microenvironment, and on the
    molecular determinants of resistance to immunotherapy, differentiating between inflamed and non-inflamed melanomas.
    [Seminars in Cancer Biology]

    Abstract

    Research Progress of Natural Tissue-Derived Hydrogels for Tissue
    Repair and Reconstruction

    The authors review the latest research advances in the field of hydrogels from a variety of natural tissue sources,
    including bone tissue, blood vessels, nerve tissue, adipose tissue, skin tissue, and muscle tissue, including preparation methods, advantages, and applications in tissue engineering, and regenerative medicine.
    [International Journal of Biological Macromolecules]

    Abstract

    INDUSTRY AND POLICY
    NEWS

    Krystal Biotech Submits
    Biologics License Application to US FDA Seeking Approval of B-VEC for the Treatment of Patients with Dystrophic Epidermolysis Bullosa

    Krystal Biotech, Inc. announced the submission of a Biologics License Application FDA seeking approval of B-VEC for the
    treatment of patients with dystrophic epidermolysis bullosa.
    [Krystal Biotech, Inc.]

    Press Release

    FEATURED EVENT

    Cell Bio 2022

    December 3 – 7, 2022
    Washington, DC, United States

    > See All Events

    JOB OPPORTUNITIES

    Research
    Technologist – Pediatrics

    Pennsylvania State University – State College, Pennsylvania, United States

    Postdoctoral Fellow –
    Interorgan Crosstalk

    Washington University School of Medicine – St. Louis, Missouri, United States

    Research Associate – Pluripotent Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    Associate
    Professor – Skin Cancer

    University College Dublin – Dublin, Ireland

    Postdoctoral
    Research Scientist – Skin Cancer

    Columbia University – New York City, New York, United States

    > See All Jobs

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