Dermal Cell News Volume 8.23 | Jul 4 2022

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    2022-07-04 | DCN 8.23


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.23 – 4 July, 2022
    TOP STORY

    A Strain-Programmed Patch for the Healing of Diabetic Wounds

    Scientists reported the development and preclinical therapeutic performance of a strain-programmed patch that rapidly and robustly adhered to diabetic wounds, and promoted wound closure and re-epithelialization.
    [Nature Biomedical Engineering]

    Abstract
    Explore scientific events this July with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State

    The authors showed that in normal mouse skin, Scube3 was expressed only in dermal papillae of growing, but not in resting follicles.
    [Developmental Cell]

    AbstractPress ReleaseGraphical Abstract

    Flexible, High-Strength and Multifunctional Polyvinyl Alcohol/MXene/Polyaniline Hydrogel Enhancing Skin Wound Healing

    Scientists found that polyvinyl alcohol/Ti3C2Tx (MXene)/polyaniline hydrogels accelerated skin wound healing by promoting angiogenesis and collagen deposition.
    [Biomaterials Science]

    AbstractGraphical Abstract

    Acacetin Resists UVA Photoaging by Mediating the SIRT3/ROS/MAPKs Pathway

    Researchers investigated the effect of Acacetin on skin photoaging in ultraviolet A (UVA)-irradiated mice and human dermal fibroblasts.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Evaluation of Different Methodologies for Primary Human Dermal Fibroblast Spheroid Formation: Automation through 3D Bioprinting Technology

    Investigators generated spheroids containing primary human dermal fibroblasts using the two-widely employed methods: hanging-drop and U-shape low adhesion plate.
    [Biomedical Materials]

    Full Article

    The Potential Role of Fibroblast-Derived Multi-Peptide Factors in Activation of Growth Factors and β-Catenin in Hair Follicle Cells

    Scientists investigated the stimulatory effects of multi-peptide factors-containing dermal fibroblast-conditioned medium on hair growth.
    [Journal of Cosmetic Dermatology]

    Abstract

    Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma

    Researchers utilized cell and murine models to demonstrate that oncogenic BRAF led to activation of the Hippo tumor suppressor pathway, both in melanocytes in vitro and nevus melanocytes in vivo.
    [Nature Communications]

    Full Article
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    REVIEWS

    -Omics Potential of In Vitro Skin Models for Radiation Exposure

    The authors explore the current state-of-the-art technology in terms of in vitro 3D skin models, as well as track the trajectory of MS-based -omics techniques and their application to ionizing radiation research.
    [Cellular and Molecular Life Sciences]

    Abstract

    Regulation of Signaling Pathways in Hair Follicle Stem Cells

    Investigators review the regulation of hair follicles, hair follicle stem cells (HFSCs), and related signaling pathways, with the aims of summarizing previous research results and revealing the regulatory mechanisms of HFSC proliferation and differentiation.
    [Burns & Trauma]

    Full Article
    INDUSTRY AND POLICY NEWS

    Zantrene Shows Impressive Synergy With BRAF & MEK Inhibitors In Treating Melanoma

    Race Oncology Limited shared the final results from our preclinical melanoma research program in collaboration with the University of Newcastle.
    [Race Oncology Ltd]

    Press Release

    FEATURED EVENT

    12th AACR-JCA Conference: Breakthroughs in Cancer Research

    December 10 – 14, 2022
    Maui, Hawai’i, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Technician – Skin Stem Cell Lab

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Research Associate – Pluripotent Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    Research Technologist – Pediatrics

    Pennsylvania State University – State College, Pennsylvania, United States

    Postdoctoral Fellow – Interorgan Crosstalk

    Washington University School of Medicine – St. Louis, Missouri, United States

    Associate Professor – Skin Cancer

    University College Dublin – Dublin, Ireland

    > See All Jobs

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