Dermal Cell News Volume 8.27 | Sep 13 2022

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    Laurisa Dohm
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    2022-09-12 | DCN 8.27


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.27 – 13 September, 2022
    TOP STORY

    Innate Type 2 Immunity Controls Hair Follicle Commensalism by Demodex Mites

    Scientists found that control of mite hair follicle colonization in mice required group 2 innate lymphoid cells, interleukin-13, and its receptor.
    [Immunity]

    Full ArticleGraphical Abstract
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    Homeostasis Limits Keratinocyte Evolution

    Using a 3D in silico homeostatic epidermis model, the authors revealed that many mutations likely lacked functional heterogeneity and were, instead, simply those that arose earlier in life within the basal layer.
    [Biophysics and Computational Biology]

    Full Article

    FRA1:c-JUN:HDAC1 Complex Down-Regulates Filaggrin Expression upon TNFα and IFNγ Stimulation in Keratinocytes

    The authors identified the molecular mechanisms by which inflammatory cytokines inhibited filaggrin expression in the skin.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    NRF2 Mediates Melanoma Addiction to GCDH by Modulating Apoptotic Signaling

    Researchers identified melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase, and its knockdown induced cell death programs in melanoma cells.
    [Nature Cell Biology]

    Abstract

    Altered Epidermal Proliferation, Differentiation, and Lipid Composition: Novel Key Elements in the Vitiligo Puzzle

    By applying cellular and lipidomic approaches, investigators found a deregulated keratinocyte differentiation with altered lipid composition.
    [Science Advances]

    Full Article

    Endogenous DOPA Inhibits Melanoma through Suppression of CHRM1 Signaling

    Using primary human melanocytes and preclinical melanoma models, researchers showed that cell-intrinsic differences between dark and light melanocytes regulated proliferative capacity and susceptibility to malignant transformation.
    [Science Advances]

    Full ArticlePress Release

    Suppression of Ca2+ Signaling Enhances Melanoma Progression

    Scientists examined UV-dependent metastasis, and revealed a critical role for store-operated Ca2+ entry suppression in melanoma progression.
    [Embo Journal]

    AbstractGraphical Abstract

    MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET

    The authors applied a transcriptome-wide screen for genes of unknown function with inverse expression patterns in differentiating keratinocytes compared with cutaneous squamous cell carcinomas.
    [Cancer Research]

    AbstractGraphical Abstract
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Microenvironmental Cue-Regulated Exosomes As Therapeutic Strategies for Improving Chronic Wound Healing

    Researchers discuss microenvironmental cue-regulated exosomes as therapeutic strategies to improve chronic wound healing.
    [NPG Asia Materials]

    Full Article
    INDUSTRY AND POLICY NEWS

    US FDA Approves Sotyktuâ„¢ Oral Treatment for Adults with Moderate-to-Severe Plaque Psoriasis

    Bristol Myers Squibb announced that the US FDA approved Sotyktuâ„¢ for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
    [Bristol Myers Squibb]

    Press Release

    US Enlists IMB To Seek New Ways To Battle Melanoma

    Researchers from the Institute for Molecular Bioscience (IMB) have been awarded international funding to combat an expected escalation of skin cancer cases in US troops who served in Iraq and Afghanistan.
    [University of Queensland]

    Press Release
    FEATURED EVENT

    Skin Ageing & Challenges 2022

    November 17 – November 18, 2022
    Lisbon, Portugal

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    JOB OPPORTUNITIES

    Chief Scientific and Medical Officer – Psoriasis

    The National Psoriasis Foundation – Alexandria, Virginia, United States

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Histology Scientist – Personalized Immunotherapy Program

    Melanoma Institute Australia – Sydney, Australia

    Senior Investigator – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Research Officer – Devices for Synthetic Biology

    National Research Council Canada – Toronto, Ontario, Canada

    > See All Jobs

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