 | | Vol. 8.28 – 19 September, 2022 |
| |
|
|
| In vitro, the lead candidate EBC-1013 stimulated protein kinase C–dependent neutrophil reactive oxygen species induction and NETosis and increased expression of wound healing–associated cytokines, chemokines, and antimicrobial peptides in keratinocytes and fibroblasts.
[Science Translational Medicine] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
|
|
|
| Investigators reported a simple method to generate materials in mammalian cells by chemically fabricating intracellular melanin. Their approach exploited synthetic tyrosine derivatives to hijack the melanin biosynthesis pathway in melanocytes.
[Journal of the American Chemical Society] |
|
|
|
| The authors showed that miR-148a, through its gene targets, played an important role in regulating skin homeostasis and hair follicle cycling.
[Journal of Investigative Dermatology] |
|
|
|
| To probe the molecular underpinnings of the mechanisms linking mechanical cues to changes in gene expression and cellular behavior, researchers used the down-regulation of caspase-8 as a biomarker of a cell entering the wound healing program.
[PLoS Biology] |
|
|
|
| Scientists used an air-liquid interface culture method to recapitulate structural features representative of human skin tissue, and to model atopic dermatitis by Staphylococcus aureus colonization and infection.
[iScience] |
| |
|
|
| Combining prevascularization and microfluidic approaches, investigators presented a vascularized, three-dimensional skin-on-chip that mimicked human skin architecture and was competent to immune-cell and drug perfusion.
[Nature Communications] |
|
|
|
| Researchers performed comprehensive genomic profiling of Merkel cell polyomavirus + (MCPyV+) and MCPyV− tumors, to better understand their mutational profiles and shed light on their pathogenesis.
[Modern Pathology] |
|  |
|
|
|
| Scientists provide an update on the recent efforts to regenerate appendage-bearing skin organs based on scaffold-free and scaffold-based bioengineering approaches.
[Advanced Healthcare Materials] |
|
|
|
| The authors summarize advancements made in understanding and treating melanoma, and discuss the progress made towards developing melanoma models, their applications, limitations, and the advances still needed.
[Experimental Dermatology] |
|
|
|
|
| Bristol Myers Squibb announced that the European Commission has approved the fixed-dose combination of Opdualag (nivolumab and relatlimab) for the first-line treatment of advanced, unresectable or metastatic, melanoma in adults and adolescents 12 years of age and older.
[Bristol Myers Squibb] |
|
|
|
|
| November 2 – 4, 2022
Lyon, France |
|
|
|
|
|
| | Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands |
|
|
|
| | The National Psoriasis Foundation – Alexandria, Virginia, United States |
|
|
|
| | National Research Council Canada – Toronto, Ontario, Canada |
|
|
|
| | Lehigh University – Bethlehem, Pennsylvania, Untied States |
|
|
|
| | Michigan State University – East Lansing, Michigan, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
