 | | Vol. 8.31 – 17 October, 2022 |
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| Investigators found that NECTIN1 loss stimulated melanoma cell migration in vitro and spreading in vivo in both zebrafish and human tumors, specifically in response to decreased IGF1 signaling.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers showed that epithelial cells sensed local cell density through mechanosensitive E-cadherin adhesions to control G2/M cell-cycle progression. As local cell density increased, tensile forces on E-cadherin adhesions were reduced, which prompted downstream inhibitory phosphorylation of Cdk1.
[Cell Reports] |
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| Scientists have identified a novel culture medium for the rapid growth of keratinocytes from human skin. “Kelch’s medium” supports keratinocyte growth that was as rapid as in the classical Rheinwald and Green method, but without the need for cholera toxin or xenogeneic feeder cells.
[Cytotherapy] |
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| Researchers found that expression of Ezh2Y641F caused upregulation of a subset of interferon-regulated genes in melanoma cells. Upregulation of these genes was not a direct effect of changes in H3K27me3, but via a non-canonical interaction between Ezh2 and Signal Transducer and Activator of Transcription 3.
[Oncogene] |
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| Scientists identified novel immunogenic peptide epitopes derived from CSC-associated Sox2 and Nanog, and synthesized synthetic high-density lipoprotein nanodisc vaccine formulated with Sox2, Nanog, and aldehyde dehydrogenase antigen peptides together with CpG, a Toll-like receptor 9 agonist.
[Journal of Controlled Release] |
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| The authors applied Cancermuts, a free bioinformatics software package, to the intrinsically disordered protein AMBRA1, a key regulator of many cellular processes frequently deregulated in cancer. By these means, they classified mutations of AMBRA1 in melanoma, where AMBRA1 is highly mutated and displays a tumor-suppressive role.
[Cell Death & Disease] |
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| Scientists emphasize the underlying molecular mechanism of reactive oxygen species (ROS)-based nanoreactors for improved therapeutic outcomes against psoriasis, and summarize up-to-date progress relating to the advantages and limitations of nanotherapeutic application for transdermal administration.
[Journal of Nanobiotechnology] |
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| The authors provide an overview of the different tissue-engineered skin substitutes that have been investigated in clinical studies to treat patients with epidermolysis bullosa. Where available, they describe the methods used to develop these products to inform future efforts in this field.
[Molecular Diagnosis & Therapy] |
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| The American Cancer Society, the largest non-government, non-profit funding source of cancer research in the United States, has approved funding for 89 new Extramural Discovery Science research grants totaling $54.3 million.
[American Cancer Society] |
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| November 14 – 17, 2022
Portland, Oregon, United States |
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| | IQVIA – Toronto, Ontario, Canada |
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| | University College Dublin – Dublin, Ireland |
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| | STEMCELL Technologies – Vancouver, British Columbia, Canada |
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| | University of Colorado Denver – Aurora, Colorado, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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