Dermal Cell News Volume 8.33 | Oct 31 2022

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    2022-10-31 | DCN 8.33


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.33 – 31 October, 2022
    TOP STORY

    Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts

    Investigators constructed a double-sided thermoresponsive mechanoactive hydrogel that combined good flexibility, self-healing, wet-tissue adhesion, and antibacterial functions.
    [ACS Nano]

    AbstractGraphical Abstract
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Reprogramming of Three-Dimensional Microenvironments for In Vitro Hair Follicle Induction

    The authors revealed that microenvironmental reprogramming via control over reciprocal cellular interactions enabled hair follicle induction in vitro. A key approach was to modulate spatial distributions of epithelial and mesenchymal cells in their spontaneous organization.
    [Science Advances]

    Full ArticlePress Release

    The Extracellular Matrix Fibulin 7 Maintains Epidermal Stem Cell Heterogeneity during Skin Aging

    Fibulin 7 interacted with structural extracellular matrix and matricellular proteins, and the overexpression of fibulin 7 in primary keratinocytes resulted in slower proliferation and suppressed differentiation.
    [EMBO Reports]

    AbstractGraphical Abstract

    Loss of Mst1/2 Activity Promotes Non-mitotic Hair Cell Generation in the Neonatal Organ of Corti

    Scientists used in vitro RNA-sequencing to show that the Hippo signaling pathway was involved in hair cell damage and self-repair processes.
    [NPJ Regenerative Medicine]

    Full Article

    Staphylococcus aureus Skin Colonization Promotes SLE-Like Autoimmune Inflammation via Neutrophil Activation and the IL-23/IL-17 Axis

    Researchers demonstrated that epithelial cell–specific IκBζ-deficient (NfkbizΔK5) mice showed spontaneous skin inflammation with increased abundance of Staphylococcus aureus on the skin.
    [Science Immunology]

    AbstractPress Release

    CDK12 Is Hyperactivated and a Synthetic-Lethal Target in BRAF-Mutated Melanoma

    Scientists found that melanoma cells harbored constitutively high CDK12 activity, and that its inhibition decreased the expression of long genes containing multiple exons, including many genes involved in DNA repair.
    [Nature Communications]

    Full Article
    The Immunology Podcast is here. Find it wherever you get your podcasts.
    REVIEWS

    A Comprehensive Review on the Applications of Carbon-Based Nanostructures in Wound Healing: From Antibacterial Aspects to Cell Growth Stimulation

    The latest studies on the application of carbon nanomaterials including graphene oxide, reduced graphene oxide, carbon dots, carbon quantum dots, carbon nanotubes, carbon nanofibers, and nanodiamonds in wound dressing applications are evaluated.
    [Biomaterials Science]

    Abstract

    NRF2, a Crucial Modulator of Skin Cells Protection against Vitiligo, Psoriasis, and Cancer

    The authors summarize the current evidence linking nuclear factor (erythroid-derived 2)-like 2 (NRF2) to skin pathophysiology and discuss some recent modulators of NRF2 activity that have shown a therapeutic efficacy in skin protection against tumor initiation and common inflammatory skin conditions.
    [Biofactors]

    Abstract
    INDUSTRY AND POLICY NEWS

    NSF to End Cost-Sharing Mandate for Some Grants to Level the Playing Field

    For the next 5 years, the National Science Foundation (NSF) will no longer require universities and other organizations to cover 30% of an award from its major research instrumentation program, which funds new equipment.
    [Science News]

    Press Release
    FEATURED EVENT

    Novel Approaches Against Emerging Antimicrobial Resistance

    December 4 – 7, 2022
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant II – Melanoma Medical Oncology

    The University of Texas M. D. Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Neural, Cardiac, Endothelial, and Adipose hiPSC Modeling

    Northwestern University – Chicago, Illinois, United States

    Research Associate – Tissue Injury and Repair

    The University of British Columbia – Vancouver, British Columbia, Canada

    Senior Bioinformaticians – Skin Cancer Research

    Wellcome Genome Campus – Saffron Walden, England, United Kingdom

    Clinical Trial Educator – Melanoma

    IQVIA – Toronto, Ontario, Canada

    > See All Jobs

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