Dermal Cell News Volume 8.34 | Nov 7 2022

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    2022-11-07 | DCN 8.34


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.34 – 7 November, 2022
    TOP STORY

    Nociceptor Neurons Affect Cancer Immunosurveillance

    The authors showed that melanoma cells interacted with nociceptor neurons, leading to increases in their neurite outgrowth, responsiveness to noxious ligands and neuropeptide release.
    [Nature]

    Full Article
    ON1104SM-Small-Molecules-Wallchart-728x90
    PUBLICATIONSRanked by the impact factor of the journal

    Fabrication and Characterization of Bilayer Scaffolds – Nanocellulosic Cryogels – for Skin Tissue Engineering by Co-Culturing of Fibroblasts and Keratinocytes

    Scaffolding materials with integrated layer structures and well interconnected and open pore structures were obtained.
    [International Journal of Biological Macromolecules]

    Abstract

    Investigating the Effects of Low Intensity Visible Light on Human Keratinocytes Using a Customized LED Exposure System

    An in vitro wound model was developed by allowing the HaCaT cells to form a confluent monolayer, then scratching the cells with a pipette tip to form a wound.
    [Scientific Reports]

    Full Article

    Overexpression of VEGF in Dermal Fibroblast Cells Accelerates the Angiogenesis and Wound Healing Function: In Vitro and In Vivo Studies

    In vitro, a novel recombinant expression vector, pcDNA3.1(-)-VEGF, was produced and transfected into fibroblast cells. Following selecting fibroblast cells with hygromycin, recombinant cells were investigated in terms of VEGF expression.
    [Scientific Reports]

    Full Article

    Organic Ultraviolet Filters Regulate Hyaluronan Metabolism in Human Epidermal Keratinocytes through the Phosphatidylinositol 3-Kinase Pathway

    Investigators studied the effects of organic UV filters on hyaluronan metabolism and skin hydration in human HaCaT keratinocytes.
    [Toxicology in Vitro]

    Abstract

    Tumor-Intrinsic SIRPA Promotes Sensitivity to Checkpoint Inhibition Immunotherapy in Melanoma

    Scientists performed integrative transcriptomic and proteomic analyses on emerging immuno-oncology targets across multiple clinical cohorts of melanoma under anti-PD-1 treatment, on both bulk and single-cell levels.
    [Cancer Cell]

    Full ArticleGraphical Abstract

    N6-Methyladenosine Reader YTHDF3 Regulates Melanoma Metastasis via Its ’Executor’ LOXL3

    The effects of YTH N6–methyladenosine RNA binding protein 3 (YTHDF3) and lysyl oxidase–like 3 in melanoma were verified in vitro and in vivo.
    [Clinical and Translational Medicine]

    Full Article

    Prediction of Early-Stage Melanoma Recurrence Using Clinical and Histopathologic Features

    Researchers aimed to assess the effectiveness of machine-learning algorithms in predicting melanoma recurrence using clinical and histopathologic features from Electronic Health Records.
    [npj Precision Oncology]

    Full ArticlePress Release

    Silencing FOXP2 Reverses Vemurafenib Resistance in BRAFV600E Mutant Papillary Thyroid Cancer and Melanoma Cells

    A vemurafenib-resistant BRAFV600E melanoma cell line was established by gradually increasing the drug concentration.
    [Endocrine]

    Full Article
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    The Effect of Menopausal Hormone Therapy on the Risk of Melanoma and Keratinocyte Skin Cancer: A Systematic Review and Meta-analysis of Observational Studies

    Investigators systematically review and meta-analyze evidence regarding the association of menopausal hormone thereapy with the risk of melanoma and keratinocyte cancer.
    [Maturitas]

    Abstract

    N6-Methyladenosine Functions and Its Role in Skin Cancer

    The authors summarize m6A methylation functions in different skin cancers, and discuss how m6A methylation is involved in disease development and progression.
    [Experimental Dermatology]

    AbstractFull Article
    INDUSTRY AND POLICY NEWS

    US Agency Seeks to Phase Out Animal Testing

    The FDA commits to exploring alternative methods to replace laboratory animals in developing new drugs and products.
    [Nature News]

    Press Release

    FEATURED EVENT

    Skin-Immune Crosstalk

    February 13 – 16, 2023
    Breckenridge, Colorado, United States

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    JOB OPPORTUNITIES

    Medical Advisor – Dermatology

    Sanofi – Amsterdam, Netherlands

    Faculty Position – Regenerative Medicine

    University of Nebraska Medical Center – Omaha, Nebraska, United States

    Research Assistant II – Melanoma Medical Oncology

    The University of Texas M. D. Anderson Cancer Center – Houston, Texas, United States

    Research Associate – Tissue Injury and Repair

    The University of British Columbia – Vancouver, British Columbia, Canada

    Senior Bioinformaticians – Skin Cancer Research

    Wellcome Genome Campus – Saffron Walden, England, United Kingdom

    > See All Jobs

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