 | | Vol. 8.35 – 14 November, 2022 |
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| The ACD promoter variants increased the expression of TPP1 and functioned together with TERT to synergistically lengthen telomeres.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers demonstrated that the electrical stimulation applied by the microneedle-based self-powered transcutaneous electrical stimulation system acted as an “adjuvant” that suppressed the reduction of epidermal growth factor by glutathione and upregulated its receptor expression in keratinocyte cells.
[Nature Communications] |
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| Scientists tested a technique which partitioned heterogeneous cell states within a geometric pattern, where boundary regions of curvature prime the stem cell-like fraction. Using melanoma cells of different metastatic potential, the authors discovered a relationship between stem fraction and nanoparticle uptake.
[Advanced Healthcare Materials] |
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| Investigators used dextran conjugated with poly(amidoamine) (Dextran-PAMAM) as a gene carrier to deliver MMP-9 targeted siRNA (siMMP-9). The prepared complexes could be endocytosed with low cytotoxicity to HaCat cells.
[Bioconjugate Chemistry] |
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| Analyzing the transcriptome of MAPK inhibitor sensitive- and resistant-melanoma, scientists discovered that APAF-1 was negatively regulated by MITF in resistant tumors, identifying the MITF/APAF-1 axis as a molecular driver of MAPK inhibitor resistance.
[Cell Reports] |
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| Investigators showed that FZD6 was overexpressed in multiple melanoma cell lines and human samples. Knockdown or knockout of FZD6 did not affect cell proliferation, but significantly reduced the invasive ability of melanoma cells.
[Journal of Investigative Dermatology] |
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| Mass spectrometry analysis of melanoma-mast cell co-cultures secretome showed that HMGA1 secretion by melanoma cells was significantly impaired.
[Immunology] |
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| MLKL-mediated necroptosis deficiency or inhibition resulted in blocking recruitment and activation of inflammatory cells in contact hypersensitivity via reducing HMGB1 release in keratinocytes.
[Cell Death Discovery] |
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| Researchers described a new topical treatment of atopic dermatitis by a nuclear transport checkpoint inhibitor, which targeted two nuclear transport shuttles, importin α5 and importin β1.
[Scientific Reports] |
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| Scientists review key roles the basement membrane components play in preserving the stem cell pool, establishing cell polarity cues enabling asymmetric cell divisions, and regeneration of the epidermis during skin healing.
[American Journal of Physiology-Cell Physiology] |
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| This global, open-label single-arm trial evaluated TAVO™, OncoSec’s proprietary IL-12 encoding plasmid delivered by intratumoral electroporation, in combination with pembrolizumab in patients with unresectable or metastatic (Stage III/IV) melanoma.
[OncoSec Medical, Inc.] |
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| Academic workers protest at the University of California, Berkeley, demanding higher salaries and better benefits from the state university system.
[STAT News] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | University of Bristol – Bristol, United Kingdom |
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| | AstraZeneca – Boston, Massachusetts, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | Sanofi – Amsterdam, Netherlands |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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