 | | Vol. 8.36 – 21 November, 2022 |
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| Researchers showed that NRASQ61 mutated melanomas specific metabolic settings mediated cell sensitivity to sorafenib upon metabolic stress.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Mesenchymal stem cell-derived nanovesicles were efficiently uptaken by human dermal fibroblasts, resulting in enhancement of cell proliferation, cell migration, secretion of growth factors and extracellular matrix proteins, which all promoted tissue regeneration.
[Acta Pharmaceutica Sinica B] |
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| HaCaT or HEKa cells were treated with lysophosphatidic acid (LPA) in the presence or absence of various chemical inhibitors. Glycolysis stress was measured using the Seahorse extracellular flux analyzer.
[Life Sciences] |
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| Chitosan/hyaluronic acid-grafted pullulan succinate materials had no cytotoxicity and increased cell proliferation when coincubated with L929 cells.
[International Journal of Biological Macromolecules] |
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| Extracellular application of keratin induced condensation of dermal papilla cells and the generation of a P-cadherin-expressing cell population (hair germ) from outer root sheath cells via keratin-mediated microenvironmental changes.
[Communications Biology] |
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| Scientists reported that 3D cell culture of dermal fibroblasts promoted secretion of exosomes carrying a large quantity of proteins involved in the formation, organisation and remodelling of the extracellular matrix.
[Scientific Reports] |
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| | In melanoma cell lines characterized by low HSPB8 levels, researchers demonstrated that the restoration of HSPB8 expression caused cell growth arrest, reversion of epithelial-mesenchymal transition-like phenotype switching and antimigratory effect.
[Cell Death & Disease] |
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| Loss-of-function approaches in B16F10 melanoma cells were used to study the cell-autonomous effects of CD248 on cell adhesion, migration, proliferation, and vascular mimicry.
[Journal of Biomedical Science] |
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| Investigators dissected the underlying molecular mechanism in imiquimod and interleukin(IL)-23-induced psoriasis-like models, and in primary normal human epidermal keratinocytes, that CCN1 could selectively induce the production of IL-36α and IL-36γ.
[Journal of Dermatology] |
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| The authors explore how epithelial cells from distinct niches respond and adapt during acute wound repair; when and where cells sense and react to damage, how cellular identity is regulated at the molecular and behavioral level, and how cells memorize past experiences and their origin.
[Cold Spring Harbor Perspectives in Biology] |
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| The FDA has delayed a biologics license application (BLA) for lifileucel, a treatment for unresectable or metastatic melanoma, until the start of 2023 due to a request for additional data on the agent.
[Targeted Oncology] |
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| March 6 – 8, 2023
Paris, France |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | University of Bristol – Bristol, United Kingdom |
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| | Imperial College London – London, England, United Kingdom |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | The University of Texas M. D. Anderson Cancer Center – Houston, Texas, United States |
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Cancer Stem Cell News
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