 | | Vol. 8.37 – 5 December, 2022 |
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| Molecularly, the expression of E-cadherin or nerve growth factor receptor, the BRAF mutation state, and level of immune cell infiltration subdivided tumors into proliferative/pigmented and invasive/stem-like/therapy-resistant.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Generation of an alkaline microenvironment enhanced boron dihydroxy groups ability to trap lipopolysaccharides or peptidoglycans through esterification, which enhanced metal cation-induced bacterial death and inhibited dead bacteria-induced excessive inflammation both in vitro and in vivo.
[Nature Communications] |
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| In burnt murine animal models, the adipose-derived stem cells-laden hydrogel significantly accelerated wound healing rate and scarless skin tissue regeneration through multiple pathways, and could avoid immune system recognition and activation and thus reduced the inflammatory response.
[Advanced Healthcare Materials] |
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| Gene silencing of p120 in fascia fibroblasts disentangled their supracellular organization, reducing the transfer of fascial cells and extracellular matrix into wounds.
[Journal of Investigative Dermatology] |
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| Spirulina platensis is a type of blue-green algae that contains large amounts of protein with therapeutic effects. In-vitro MTT toxicity studies on the HFFF-2 cell line showed that the hydrolyzed peptides had no toxic effect and increased cell growth.
[International Journal of Pharmaceutics] |
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| | Investigators observed that the loss of MFSAP1 resulted in dramatic changes in the cell adhesion and dispersal in both culture and a human 3D reconstituted epidermis model.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Treatment of mouse melanoma cell lines with interferon-gamma enhanced their tumorigenicity and metastasis in lung colonization allograft assays performed in immunocompetent syngeneic host mice, but not in immunocompromised host mice.
[Oncogene] |
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| Researchers found that subcutaneous application of umbilical cord-derived mesenchymal stem/stromal cells primed by interferon-γ and tumor necrosis factor-α exhibited remarkable therapeutic efficacy on imiquimod-induced psoriasis-like inflammation in mice.
[Cell Death & Disease] |
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| The antioxidant activity and potential molecular mechanisms of H-2 were investigated using Caenorhabditis elegans and mouse melanoma cell B16-F10 models.
[Biomedicine & Pharmacotherapy] |
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| The authors review current knowledge on the mechanisms, functions, and implications for therapeutic approaches of the effects of melatonin on mammalian melanocytes and melanoma.
[Experimental Dermatology] |
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| The US FDA has granted Fast Track designation to IDEAYA’s development program investigating darovasertib, a potential first-in-class protein kinase C inhibitor, for use in combination with crizotinib, for the treatment of adult patients with metastatic uveal melanoma.
[IDEAYA Biosciences, Inc.] |
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| January 24 – 26, 2023
Boston, Massachusetts, United States |
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| | Columbia University Medical Center – New York City, New York, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Indiana University School of Medicine – Bloomington, Indiana, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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