 | | Vol. 8.38 – 12 December, 2022 |
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| Single-cell multi-omics revealed that uninjured reindeer velvet fibroblasts resembled human fetal fibroblasts, whereas reindeer back skin fibroblasts expressed inflammatory mediators mimicking pro-fibrotic adult human and rodent fibroblasts.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Fatty acid desaturation catabolized by stearoyl-coenzyme A desaturase 1 (SCD1) regulated hair follicle stem cells (HFSCs) and hair growth by maintaining the bulge, niche for HFSCs.
[Advanced Science] |
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| The biotherapeutic gel was constructed by incorporating stable microbial communities (kombucha) capable of producing antimicrobial substances and organic acids into thermosensitive Pluronic F127 (polyethylene-polypropylene glycol) solutions.
[Advanced Science] |
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| The authors provide a map of the early angiogenic niche by analyzing single-cell RNA sequencing of mouse skin wound healing. The data implicate Langerhans cells, phagocytic, skin-resident immune cells, in driving angiogenesis during skin repair.
[Developmental Cell] |
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| Scientists report a multi-omics longitudinal dataset for cultured primary human fibroblasts measured across their replicative lifespans. The dataset includes cytological, bioenergetic, DNA methylation, gene expression, secreted proteins, telomere length, whole-genome sequencing, and other measurements.
[Scientific Data] |
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| CD1a is a virtually monomorphic major histocompatibility complex class I-like molecule, highly expressed by skin and mucosal Langerhans cells, and presents lipid antigens to T cells. Researchers showed an important role for CD1a in linking cutaneous and systemic inflammation in two experimental disease models.
[Nature Communications] |
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| Using computational tools, organoids, and spatial tools, the authors showed that LY6D+ basosquamous cells represented a persister population lying on a central node along the skin lineage-associated spectrum of epithelial states.
[Nature Communications] |
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| Researchers leveraged the tunable abundance of MEK inhibition-modulated antigens by targeting four epitopes with peptide major histocompatibility molecules (pMHC)-specific T cell engagers and antibody drug conjugates, enhancing cell killing in melanoma cells following MEK inhibition.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Findings indicated that BET inhibition suppressed melanoma metastasis both in vitro and in vivo, and identified a new mechanism by which BET inhibitors blocked the direct interaction of BRD4 and the SPINK6 enhancer.
[Pharmacological Research] |
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| The authors first delineate what is known about the origins of the dermis and the central role of Wnt/β-catenin signaling in its specification across anatomical locations, and then discuss how one of the first morphologically recognizable fibroblast subtypes, the hair follicle dermal condensate lineage, emerges.
[Development] |
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| RP1 combined with nivolumab demonstrated an overall response rate of 36% and complete response rate of 20%, with clinically meaningful activity across a broad range of anti-PD1 failed cutaneous melanoma settings observed, in an initial data snapshot from the first 75 patients in the IGNYTE clinical trial.
[Replimune Group Inc.] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | Novartis – Boston, Massachusetts, United States (Remote) |
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| | Center for Nanomedicine and Tissue Engineering – Milan, Italy |
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| | Columbia University Medical Center – New York City, New York, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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