 | | Vol. 9.00 – 9 January, 2023 |
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| Using in vitro and in vivo models that recapitulated human melanoma progression, the authors found that expression of inner nuclear membrane protein, LAP1C, supported nuclear envelope blebbing, constrained migration, and invasion.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Using a model of organ regeneration called wound-induced hair follicle neogenesis, scientists identified skin-resident bacteria as key modulators of keratinocyte metabolism, demonstrating a positive correlation between bacterial load, glutamine metabolism, and regeneration.
[Science Advances] |
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| Investigators developed cochlear organoids with functional peripheral auditory circuity in a staging three-dimensional co-culture system by initially reprogramming cochlear progenitor cells with increased proliferative potency that could be long-term expanded.
[Stem Cell Reports] |
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| Nude mice were used to prepare a full-thickness skin defect wound model to detect the repair effect of epidermal stem cells (EpiSCs). The biosafety of EpiSCs was double tested in vitro and in vivo.
[Stem Cell Research & Therapy] |
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| Researchers tested if hair follicles transplanted into human scars could facilitate tissue regeneration and actively remodel fibrotic tissue, similar to how they remodel the healthy skin.
[Npj Regenerative Medicine] |
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| Using chromatin immunoprecipitation assay and RNA sequencing, scientists showed that compound TT-012 inhibited the transcriptional activity of microphthalmia transcription factor (MITF) in B16F10 melanoma cells.
[Cell Research] |
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| Specific depletion of pyruvate kinase M2 in keratinocytes attenuated the development of experimental psoriasis by reducing the production of pro-inflammatory mediators.
[Cell Reports] |
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| Researchers demonstrated that upon doxorubicin treatment transglutaminase type 2 translocated into the nucleus of apoptotic melanoma cells, interacting with interferon regulatory factor 3 (IRF3) dimers.
[Cell Death Discovery] |
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| Scientists conducted a miRNA profiling analysis of skin, as well as serum, from adult atoptic dermatitis and psoriasis vulgaris patients, and control individuals.
[Scientific Reports] |
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| Investigators discuss the tissue, cellular and molecular mechanisms that drive clinical heterogeneity in psoriatic arthritis phenotypes, and detail existing tissue-based research, including data generated using sophisticated interrogative technologies with single-cell precision.
[Nature Reviews Rheumatology] |
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| The authors provide critical comments on current advances in extracellular vesicles derived from mesenchymal stem cells for wound repair, elaborating on their roles in eliminating infections, inhibiting inflammation, promoting angiogenesis, and reducing scar formation.
[Acs Biomaterials Science & Engineering] |
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| NIVISâ„¢ Fibrillar Collagen Pack is an absorbent matrix of Type I and Type III bovine collagen designed to manage moderately to heavily exudating wounds and to control minor bleeding.
[TELA Bio, Inc.] |
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| February 15 – 17, 2023
Lorne, Victoria, Australia |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Stanford Medicine – Stanford, California, United States |
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| | US FDA – Silver Spring, Maryland, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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