Dermal Cell News Volume 9.01 | Jan 16 2023

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    Laurisa Dohm
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    2023-01-16 | DCN 9.01


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.01 – 16 January, 2023
    TOP STORY

    Role of MR1-Driven Signals and Amphiregulin on the Recruitment and Repair Function of MAIT Cells during Skin Wound Healing

    The authors used a human-like mouse model of full-thickness skin excision to assess the underlying mechanisms of mucosal associated invariant T (MAIT) cell tissue repair function.
    [Immunity]

    Full ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Use of Mouse Primary Epidermal Organoids for USA300 Infection Modeling and Drug Screening

    Investigators showed that mouse primary epidermal organoids support USA300 colonization and invasion, exhibiting swollen epithelial squamous cells with nuclear necrosis and secreting inflammatory factors such as IL-1β.
    [Cell Death & Disease]

    Full Article

    Angiopoietin-1 Derived Peptide Hydrogel Promotes Molecular Hallmarks of Regeneration and Wound Healing in Dermal Fibroblasts

    Scientists utilized solvent cast Q-peptide conjugated collagen-chitosan seeded with fibroblast monolayers to investigate the direct impact of the material on this major cell type in the context of wound healing.
    [iScience]

    Full ArticleGraphical Abstract

    Expression of PKM2 in Wound Keratinocytes Is Coupled to Angiogenesis during Skin Repair In Vivo and in HaCaT Keratinocytes In Vitro

    Immunohistochemistry and RNA in situ hybridization analysis showed a confined pyruvate kinase M (Pkm2) expression to keratinocytes of the hyperproliferative epithelium and, to a lesser extent, infiltrating neutrophils and monocytes.
    [Journal Of Molecular Medicine]

    Full Article

    Apremilast Prevents Blistering in Human Epidermis and Stabilizes Keratinocyte Adhesion in Pemphigus

    Apremilast abrogated pemphigus autoantibody-induced loss of keratinocyte cohesion in ex vivo human epidermis, cultured keratinocytes in vitro and in vivo in mice.
    [Nature Communications]

    Full Article

    Escape from NK Cell Tumor Surveillance by NGFR-Induced Lipid Remodeling in Melanoma

    Using in vitro and in vivo cytotoxic assays, investigators showed that NGFR protected melanoma cells from natural killer (NK) cell–mediated killing and, furthermore, boosted metastasis formation in a mouse model with adoptively transferred human NK cells.
    [Science Advances]

    Full Article

    WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth

    In a subset of prostate cancer organoid culture and xenograft models, inhibition of Wnt synthesis stimulated growth, while WNT5a or a WNT5a mimetic peptide markedly suppressed tumor growth.
    [Cancer Research]

    Abstract

    Next Generation of Oncolytic Viruses with the Double Transgenes PADI1 and TIMP-2 Exhibit Anti-tumor Activity Against Melanoma in Nude Mouse and Humanized NOG Mouse Models

    ONCOS-207 which expressed Tissue Inhibitors of Metalloprotease type 2, ONCOS-209 which expressed peptidyl arginine deiminase, ONCOS-210 and ONCOS-212 which expressed both TIMP-2 and PADI1, exhibited oncolytic activity against four melanoma cell lines in vitro.
    [Molecular Therapy-Oncolytics]

    Full ArticleGraphical Abstract

    PCSK9 Facilitates Melanoma Pathogenesis via a Network Regulating Tumor Immunity

    PCSK9’s association with melanoma was analyzed using the TCGA dataset. Empty vector, PCSK9, gain-of-function, and loss-of-function PCSK9 mutants were stably-expressed in murine melanoma B16 cells and studied for impact on B16 cell-derived oncogenesis in vitro and in vivo.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    Comparative Study of In Vitro Autofluorescence of Normal versus Non-Melanoma-Skin-Cancer Cells at Different Excitation Wavelengths

    Skin cells were cultivated in vitro, to isolate their characteristic autofluorescence form the more complex one that would be originated by the complete skin tissue.
    [Journal Of Biophotonics]

    Abstract
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    REVIEWS

    Keratinocytic Skin Cancers—Update on the Molecular Biology

    The authors summarize the latest knowledge about the molecular pathways and therapeutic opportunities attendant to keratinocytic skin cancers.
    [Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    SFA Therapeutics Announces FDA Clearance for Amendment to Extend Phase Ib Trial of SFA-002 for Psoriasis

    SFA Therapeutics, Inc.announced that it has received clearance from the US FDA to proceed with an extension to the ongoing Phase Ib clinical trial of SFA-002, an investigational drug candidate for psoriasis.
    [SFA Therapeutics, Inc.]

    Full Article

    SCOHIA PHARMA and Kuria Therapeutics Announce Issuance of Key Patent Covering Novel Nrf2 Activator

    SCOHIA PHARMA, Inc. and Kuria Therapeutics announced that the US Patent Office has issued a composition-of-matter patent covering SCO-116, a novel Nrf2 activator being developed by Kuria for prevention and treatment of eye and skin diseases.
    [SCOHIA PHARMA, Inc]

    Full Article
    FEATURED EVENT

    Multispecific Immune Cell Engagers for Cancer Immunotherapy

    February 19 – 22, 2023
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Director of Scientific Communications – Dermatology

    Icahn School of Medicine at the Mount Sinai Medical Center – New York, New York, United States

    PhD Student/Post-Doctoral Fellow – Microbiome-Host Interactions & Immunotherapy

    Bar-Ilan University – Ramat Gan, Israel

    Group Leader – Cell Biology

    Pompeu Fabra University – Barcelona, Spain

    Postdoctoral Fellow – Protease Proteomics

    The University of British Columbia – Vancouver, British Columbia, Canada

    Principal Investigator – Division of Cellular and Gene Therapies

    US FDA – Silver Spring, Maryland, United States

    > See All Jobs

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