Dermal Cell News Volume 9.02 | Jan 23 2023

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    Laurisa Dohm
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    2023-01-23 | DCN 9.02


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.02 – 23 January, 2023
    TOP STORY

    Fucosylation of HLA-DRB1 Regulates CD4+ T Cell-mediated Anti-Melanoma Immunity and Enhances Immunotherapy Efficacy

    The authors reported that dietary administration of L-fucose induced fucosylation and cell surface enrichment of the major histocompatibility complex-II protein HLA-DRB1 in melanoma cells, triggering CD4+ T cell-mediated increases in intratumoral immune cells and anti-tumor immunity.
    [Nature Cancer]

    Full ArticlePress Release
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    DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

    Using Keratin 14–Cre–driven ablation of Tet genes in skin epithelial cells, investigators demonstrated that ablation of Tet2/Tet3 resulted in marked alterations of hair shape and length followed by hair loss.
    [Science Advances]

    Full Article

    TRPV3-ANO1 Interaction Positively Regulates Wound Healing in Keratinocytes

    Using an in vitro wound-healing assay, scientists observed that either a transient receptor potential vanilloid 3 (TRPV3) blocker, an anoctamin1 (ANO1) blocker, or low chloride medium inhibited keratinocyte migration and proliferation through p38 phosphorylation.
    [Communications Biology]

    Full Article

    Characterization of an Ablative Fractional CO2 Laser-Induced Wound-Healing Model Based on In Vitro 3D Reconstructed Skin

    A 3D full-thickness skin model was fabricated and treated with fractional ablative CO2 laser. Wound-healing process was characterized by HE staining, noninvasive OCT imaging, immunostaining, as well as transepidermal water loss measurement.
    [Journal Of Cosmetic Dermatology]

    Full Article

    Adult Skin Fibroblast State Change in Murine Wound Healing

    Investigators analyzed scRNA-seq datasets of normal and wounded skin from mice at day four post-wound to investigate fibroblast heterogeneity during the proliferative phase of wound healing.
    [Scientific Reports]

    Full Article

    Printable Hyaluronic Acid Hydrogel Functionalized with Yeast-Derived Peptide for Skin Wound Healing

    Scientists developed printable hyaluronic acid based hydrogel to deliver yeast-derived ACE-inhibitory peptide of VLSTSFPPW to the wound site. Fibroblast cells seeded on the peptide-modified hydrogels exhibited higher viability than the hydrogels without the peptide.
    [International Journal Of Biological Macromolecules]

    AbstractGraphical Abstract

    Exosomal miR-211-5p Regulates Glucose Metabolism, Pyroptosis, and Immune Microenvironment of Melanoma through GNA15

    Researchers showed that the highly metastatic melanoma tumor cells could transfer their metastatic competency to the low-metastatic melanoma tumor cells by exosomal miR-211-5p.
    [Pharmacological Research]

    Full ArticleGraphical Abstract

    Multiple Predictive Biomarker Testing in Melanoma: Another Challenge for the Optimal Approach on Cytological Samples

    To examine the utility of fine-needle cytology for PD-L1 assessment, the authors evaluated the cellular adequacy of residual cell block material from metastatic melanomas previously tested for BRAF and NRAS mutations.
    [Cytopathology]

    Abstract

    Antiangiogenic Activity of the Penicillin Derivative TAP7f in Melanoma

    In a gel plug assay TAP7f blocked vascular formation induced by fibroblast growth factor 2. Furthermore, when murine B16-F10 melanoma cells pre-treated with TAP7f were injected intradermally in mice, investigators observed a decrease in the number and thickness of the capillaries surrounding the tumor.
    [Journal Of Molecular Medicine]

    Abstract
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    REVIEWS

    Opportunities and Challenges in the Diagnostic Utility of Dermal Interstitial Fluid

    Scientists provide an overview of the most meaningful differences in the make-up of interstitial fluid (ISF) and blood, and discuss why ISF cannot be viewed generally as a diagnostically useful proxy for blood.
    [Nature Biomedical Engineering]

    Full Article

    Epigenetic Regulation of Macrophage Polarization in Wound Healing

    The authors describe the latest knowledge concerning the potential epigenetic mechanisms that precisely regulate the biological function of macrophages and their effects on skin wound healing.
    [Burns & Trauma]

    Full Article
    INDUSTRY AND POLICY NEWS

    Evaxion Receives FDA Fast-Track Designation for Personalized Cancer Immunotherapy

    Evaxion Biotech A/S announced that the FDA has granted fast track designation for their personalized cancer therapy, EVX-01, in combination with KEYTRUDA® for patients with metastatic melanoma.
    [Evaxion Biotech A/S]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2023

    April 14 – 19, 2023
    Orlando, Florida, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – CAR T immunotherapy

    Imperial College London – London, England, United Kingdom

    Research Associate – Organoid Models of Development and Repair

    The University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Researcher – Complex Human Ex Vivo Models of Tissue Inflammation

    BioMed X Institute – New Haven, Connecticut, United States

    Director of Scientific Communications – Dermatology

    Icahn School of Medicine at the Mount Sinai Medical Center – New York, New York, United States

    PhD Student/Post-Doctoral Fellow – Microbiome-Host Interactions & Immunotherapy

    Bar-Ilan University – Ramat Gan, Israel

    > See All Jobs

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