Dermal Cell News Volume 9.04 | Feb 6 2023

February 6, 2023

2023-02-06 | DCM 9.04

Dermal Cell News by STEMCELL Technologies

Vol. 9.04 – 6 February, 2023

TOP STORY

Obstructive Sleep Apnea Is Related to Melanoma Aggressiveness through Paraspeckle Protein-1 Upregulation

The effect of paraspeckle component 1 on the expression of epithelial–mesenchymal transition and cancer stem cell transcription factors was assessed using melanoma cell lines with patient sera under both normoxia and intermittent hypoxia conditions.
[European Respiratory Journal]

Abstract

Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.

PUBLICATIONSRanked by the impact factor of the journal

DERMAL STEM CELLS & TISSUE REGENERATION

Differential Cell Composition and Split Epidermal Differentiation in Human Palm, Sole, and Hip Skin

Scientists identified specific fibroblast populations that appeared to orchestrate key differences in cell-cell communication in palm, sole, and hip.
[Cell Reports]

Full Article Graphical Abstract

ZIF-8 Integrated with Polydopamine Coating as a Novel Nano-Platform for Skin-Specific Drug Delivery

Researchers developed a novel kind of nanoparticular system based on zeolitic imidazolate framework-8 (ZIF-8) and polydopamine modification for improving the dermal delivery of 5-fluorouracil.
[Journal Of Materials Chemistry B]

Abstract Graphical Abstract

Pressure Does Not Affect Fibrotic Function of Dermal Fibroblast through an In Vitro 3D Hydrogel Culture Model

Scientists adopted an in vitro 3D culture and compression model to explore the effect of pressure force on fibroblasts, in order to further explain the working mechanism of compression force during pressure treatment.
[International Wound Journal]

Full Article

SKIN CANCERS & DISORDERS

The Mechanosensitive TRPV2 Calcium Channel Promotes Human Melanoma Invasiveness and Metastatic Potential

The authors uncovered the prominent expression of the plasma membrane TRPV2 calcium channel as a distinctive feature of melanoma tumors, directly related to melanoma metastatic dissemination.
[EMBO Reports]

Full Article Graphical Abstract

Loss of Dyskerin Facilitates the Acquisition of Metastatic Traits by Altering the Mevalonate Pathway

Investigators reported the reduced expression of small nucleolar RNAs in primary cutaneous squamous cell carcinomas (cSCCs) that metastasized, when compared to non-metastasizing cSCCs, and the progressive loss of dyskerin along the metastasis.
[Life Science Alliance]

Full Article Graphical Abstract

Pueraria Protein Extract Inhibits Melanogenesis and Promotes Melanoma Cell Apoptosis through the Regulation of MITF and Mitochondrial-Related Pathways

The anti‑melanogenic effect of P. Lobata Radix water‑soluble total protein extract (PLP) and the inhibitory effect on B16 melanoma cells were investigated. PLP significantly reduced the tyrosinase activity and melanin content in B16 melanoma cells.
[Molecular Medicine Reports]

Abstract

LncRNA HAGLR May Aggravate Melanoma Malignancy via miR-4644/ASB11 Pathway

The levels of HAGLR, miR-4644, and ASB11 in melanoma cells and tissues were assessed using quantitative real‑time PCR and western blotting.
[Molecular Biotechnology]

Abstract Graphical Abstract

Try proven workflows for your hPSC culture. Click to request your offer now.

REVIEWS

Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration

Wound-induced hair neogenesis provides a potential therapeutic window for manipulating cell fate by the introduction of factors during the wound healing process to enhance hair follicle formation.
[Cold Spring Harbor Perspectives in Biology]

Abstract

INDUSTRY AND POLICY NEWS

Anaveon Doses First Patient in a Phase I/II Study of ANV419 as Monotherapy or in Combination with Check Point Inhibitors in Patients with Advanced Melanoma

Anaveon announced the first patient has been dosed in the OMNIA-1 study – a Phase I/II study assessing the efficacy and safety of ANV419 for the treatment of advanced melanoma.
[Anveon]

Full Article

FEATURED EVENT

Dermal Cell News Volume 9.04 | Feb 6 2023

Obstructive Sleep Apnea Is Related to Melanoma Aggressiveness through Paraspeckle Protein-1 Upregulation

Differential Cell Composition and Split Epidermal Differentiation in Human Palm, Sole, and Hip Skin

ZIF-8 Integrated with Polydopamine Coating as a Novel Nano-Platform for Skin-Specific Drug Delivery

Pressure Does Not Affect Fibrotic Function of Dermal Fibroblast through an In Vitro 3D Hydrogel Culture Model

The Mechanosensitive TRPV2 Calcium Channel Promotes Human Melanoma Invasiveness and Metastatic Potential

Loss of Dyskerin Facilitates the Acquisition of Metastatic Traits by Altering the Mevalonate Pathway

Pueraria Protein Extract Inhibits Melanogenesis and Promotes Melanoma Cell Apoptosis through the Regulation of MITF and Mitochondrial-Related Pathways

LncRNA HAGLR May Aggravate Melanoma Malignancy via miR-4644/ASB11 Pathway

Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration

Anaveon Doses First Patient in a Phase I/II Study of ANV419 as Monotherapy or in Combination with Check Point Inhibitors in Patients with Advanced Melanoma

Cell Culture Engineering XVIII

> See All Events

Associate Professor – Department of Cell and Molecular Biology

Research Associate – Oncogenic Signaling

Scientist – Asthma & Skin Immunity

Research Associate – Regenerative Therapies

Research Associate – CAR T Immunotherapy

> See All Jobs