Dermal Cell News Volume 9.06 | Feb 13 2023

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    2023-02-13 | DCN 9.05


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.05 – 13 February, 2023
    TOP STORY

    The Developmental Basis of Fingerprint Pattern Formation and Variation

    Researchers showed that fingerprint ridges were epithelial structures that underwent a truncated hair follicle developmental program and failed to recruit a mesenchymal condensate.
    [Cell]

    Full ArticleGraphical Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    3D Bioprinting of Heterogeneous Tissue-Engineered Skin Containing Human Dermal Fibroblasts and Keratinocytes

    Different gelatin methacrylate/nano-cellulose bioink formulations were used to develop heterogeneous tissue-engineered skin containing layers of fibroblast networks with larger pores, basal layers with smaller pores, and multilayered keratinocytes.
    [Biomaterials Science]

    AbstractGraphical Abstract

    A Comparative Study of the In Vitro Permeation of 2-Phenoxyethanol in the Skin PAMPA Model and Mammalian Skin

    Investigators assessed the suitability of the skin parallel artificial membrane permeability assay model for prediction of skin permeation of 2-phenoxyethanol.
    [International Journal Of Pharmaceutics]

    AbstractGraphical Abstract

    A Mechanistic Evaluation of Human Beta Defensin 2 Mediated Protection of Human Skin Barrier In Vitro

    Application of exogenous human beta-defensin 2 provided protection against V8, irrespective of timeline of application or native peptide folding, raising the prospect of simple peptide analogues as therapeutics.
    [Scientific Reports]

    Full Article

    Positive Effect of Acellular Amniotic Membrane Dressing with Immobilized Growth Factors in Skin Wound Healing

    To study the acceleration of the wound healing process, researchers bound epidermal growth factor and fibroblast growth factor 1 to heparinized human acellular amniotic membrane.
    [Journal Of Biomedical Materials Research Part A]

    Abstract

    LL-37-dsRNA Complexes Modulate Immune Response via RIG-I in Oral Keratinocytes

    The authors investigated the effect of LL-37 on CXCL10 induced by damage-associated molecular patterns and pathogen-associated molecular patterns in immortalized oral keratinocytes, RT7.
    [Inflammation]

    Abstract

    Viaminate Ameliorates Propionibacterium acnes-Induced Acne via Inhibition of the TLR2/NF-κB and MAPK Pathways in Rats

    Transcriptome analysis of rat skin tissues suggested that viaminate had significant regulatory effects on fatty acid metabolism and cellular keratinization pathways.
    [Naunyn-Schmiedebergs Archives Of Pharmacology]

    Abstract

    miR-133a-3p Regulates the Growth of Hair Follicle Stem Cells in White Goats from the Yangtze River Delta

    Hair follicle stem cells (HFSCs) were isolated using the technique of immunohistochemistry from the cervical spinal skin tissue samples from the fetal sheep, and the miR-133a-3p expression was confirmed using quantitative reverse-transcription PCR and western blotting experiments from the isolated HFSCs.
    [Animal Biotechnology]

    Abstract

    The Elongin BC Complex Negatively Regulates AXL and Marks a Differentiated Phenotype in Melanoma

    Scientists described a fluorescence-activated cell sorting-based whole genome-wide CRISPR-Cas9 screen to uncover regulators of AXL expression.
    [Molecular Cancer Research]

    Abstract

    Analyzing the Mechanism by Which Oyster Peptides Target IL-2 in Melanoma Cell Apoptosis Based on RNA-Seq and m6A-Seq†

    A high-throughput strategy combined with MALDI TOF/TOF-MS and molecular docking was developed to screen peptides with antitumor functions from oyster hydrolysate. Three dominant peptides were predicted to have similar functions to IL-2 via molecular docking.
    [Food & Function]

    AbstractGraphical Abstract
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    REVIEWS

    The Sweet Side of Wound Healing: Galectins as Promising Therapeutic Targets in Hemostasis, Inflammation, Proliferation, and Maturation/Remodeling

    The authors provide an overview of the biological role of galectins in repair and regeneration, focusing on four main phases of skin repair using basic wound models.
    [Expert Opinion On Therapeutic Targets]

    Abstract

    ΔNp63α-Mediated Epigenetic Regulation in Keratinocyte Senescence

    To systematically elucidate how ΔNp63α affected keratinocyte senescence via epigenetic regulation, scientists comprehensively compiled the literature on the roles of ΔNp63α in keratinocyte senescence and epigenetics in cellular senescence.
    [Epigenetics]

    Full Article

    INDUSTRY AND POLICY NEWS

    Onconova Therapeutics Announces Additional Clinical Data Demonstrating Rigosertib’s Monotherapy Activity In RDEB-Associated Squamous Cell Carcinoma

    Onconova Therapeutics, Inc. announced that the 2nd of two evaluable participants in a Phase II program evaluating rigosertib monotherapy in advanced squamous cell carcinoma complicating recessive dystrophic epidermolysis bullosa achieved a complete response of all cancerous skin lesions following 4 treatment cycles and remains on oral rigosertib.
    [Onconova Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    OrganoidNL Symposium 2023

    March 31, 2023
    Amsterdam, The Netherlands

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    JOB OPPORTUNITIES

    Associate Professor – Biomedical Engineering

    Khalifa University – Abu Dhabi, United Arab Emirates

    Associate Professor – Department of Cell and Molecular Biology

    University of Mississippi Medical Center – Jackson, Mississippi, United States

    Research Associate – Oncogenic Signaling

    Imperial College London – London, England, United Kingdom

    Research Associate – Regenerative Therapies

    Dresden University of Technology – Dresden, Germany

    Research Associate – CAR T Immunotherapy

    Imperial College London – London, England, United Kingdom

    > See All Jobs

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