Dermal Cell News Volume 9.07 | Mar 6 2023

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    2023-03-06 | DCN 9.07


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.07 – 6 March, 2023
    TOP STORY

    Blebs Promote Cell Survival by Assembling Oncogenic Signalling Hubs

    The authors showed by 3D imaging and manipulation of cell morphological states that blebbing triggered the formation of plasma membrane-proximal signaling hubs that confer anoikis resistance
    [Nature]

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    PUBLICATIONSRanked by the impact factor of the journal

    Identification of a Physiologic Vasculogenic Fibroblast State to Achieve Tissue Repair

    Investigators transfected human dermal fibroblasts with anti-miR-200b oligonucleotide, then using single cell RNA sequencing, identified emergence of a vasculogenic subset with a distinct fibroblast transcriptome and demonstrated blood vessel forming function in vivo.
    [Nature Communications]

    Full ArticlePress Release

    Human Skin Specific Long Noncoding RNA HOXC13-AS Regulates Epidermal Differentiation by Interfering with Golgi-ER Retrograde Transport

    In line with its enrichment in suprabasal keratinocytes, HOXC13-AS was found to be increasingly expressed during keratinocyte differentiation, but its expression was reduced by EGFR signaling.
    [Cell Death & Differentiation]

    Full Article

    Opsin 3 Mediates UVA-Induced Keratinocyte Supranuclear Melanin Cap Formation

    Researchers found that opsin 3 was an important photoreceptor in human epidermal keratinocytes and was critical for ultraviolet Amediated supranuclear cap formation.
    [Communications Biology]

    Full Article

    Tissue-Mimetic Culture Enhances Mesenchymal Stem Cell Secretome Capacity to Improve Regenerative Activity of Keratinocytes and Fibroblasts In Vitro

    The authors characterized how the improved culture of adipose-derived mesenchymal stem cells within a tissue-mimetic 3D hydrogel system, that was mechanically similar to native adipose tissue, enhanced their regenerative capabilities.
    [Wound Repair And Regeneration]

    Abstract

    Metabolic Rewiring in Keratinocytes by miR-31-5p Identifies Therapeutic Intervention for Psoriasis

    Scientists showed that this miR-31-induced secretory phenotype was sufficient to induce Th17 cell differentiation, a hallmark of psoriasis.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Lysosomal Function and Intracellular Position Determine the Malignant Phenotype in Malignant Melanoma

    Rab7a expression was lower in melanoma cells than in melanocytes and, by increasing Rab7a, lysosomes were relocated to the perinuclear region in melanoma.
    [Journal Of Investigative Dermatology]

    Full Article

    The Hedgehog/GLI Signaling Pathway Activates Transcription of Slug (Snail2) in Melanoma Cells

    The authors investigated the transcriptional regulation of the SLUG gene in melanoma. It demonstrated that SLUG is under the control of the Hedgehog/GLI signaling pathway and is activated predominantly by the transcription factor GLI2.
    [Oncology Reports]

    Abstract

    Niclosamide Inhibits Epithelial-Mesenchymal Transition with Apoptosis Induction in BRAF/ NRAS Mutated Metastatic Melanoma Cells

    Researchers found that niclosamide induces significant ROS generation and apoptosis through a series of molecular mechanisms, such as depolarization of mitochondrial membrane potential, arresting the cell cycle at the sub G1 phase with a significant increase in the DNA cleavage via topoisomerase II in both cell lines.
    [Toxicology In Vitro]

    Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    REVIEWS

    Targeting IL-36 in Inflammatory Skin Diseases

    IL-36α and IL-36γ are mainly expressed by keratinocytes in the epidermis, although they are also produced by dendritic cells, macrophages, endothelial cells, and dermal fibroblasts.
    [BioDrugs]

    Abstract
    INDUSTRY AND POLICY NEWS

    Evelo Biosciences Reports that EDP2939, its First Oral Extracellular Vesicle Product Candidate, Commenced Dosing in a Phase II Psoriasis Trial

    Evelo Biosciences, Inc. announced that its first extracellular vesicle product candidate, EDP2939, has progressed to dosing in a Phase II psoriasis clinical trial after completing a safety and tolerability review from a first cohort of human volunteers.
    [Evelo Biosciences, Inc.]

    Press Release

    ASLAN Pharmaceuticals to Advance Novel DHODH Inhibitor Farudodstat Into Phase II Clinical Testing as Potential First-In-Class Treatment for Alopecia Areata

    ASLAN Pharmaceuticals announced that it is advancing its clinical program to investigate farudodstat, an oral dihydroorotate dehydrogenase inhibitor, in a Phase II proof-of-concept trial as a potential first-in-class treatment for alopecia areata.
    [ASLAN Pharmaceuticals]

    Press Release
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    JOB OPPORTUNITIES

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