 | | Vol. 9.08 – 13 March, 2023 |
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| In line with its enrichment in suprabasal keratinocytes, HOXC13-AS was found to be increasingly expressed during keratinocyte differentiation, but its expression was reduced by EGFR signaling.
[Cell Death & Differentiation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| To study the interaction of invadopodia with focal adhesion and how invadopodia turn-over is associated with invasion-migration transition cycles, researchers investigated the role of Pyk2, cortactin, and Tks5 in invadopodia turnover and their relation with focal adhesions.
[Cell Death & Disease] |
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| The authors investigated the role of commensal skin bacterium Staphylococcus epidermidis-derived extracellular vesicles, in the context of atopic dermatitis.
[Journal Of Investigative Dermatology] |
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| Researchers aimed to establish an effective method of transient miRNA mimic transfection into human dermal fibroblasts. The experimental conditions included three different methods: Physical/mechanical nucleofection, and two lipid‑based methods, Viromer® Blue and INTERFERin®.
[Molecular Medicine Reports] |
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| Scientists produced a bilayer structure by gelling GeIMA in between two nanofiber membranes to imitate the epidermal and dermal layers of skin. Cytocompatibility properties of nanofiber membrane and bilayer structure were characterized by mono- and coculture of keratinocytes and fibroblasts, respectively.
[Journal Of Biomaterials Applications] |
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| The authors used a drug synergy screen that combined a ferroptosis inducer, RSL3, with 240 anti-tumor drugs from the FDA-approved drug library and identified lorlatinib to synergize with RSL3 in melanoma cells.
[Redox Biology] |
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| Scientists demonstrated that RSL3-induced death of A375 melanoma cells in vitro was fully preventable by ferrostatin-1, suggesting their high susceptibility to ferroptosis.
[Redox Biology] |
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| Investigators identified melanin pigment content as a major source of cellular heterogeneity in melanoma and compared RNAseq data from high-pigmented and low-pigmented melanoma cells, suggesting EZH2 as a master regulator of these states.
[Oncogene] |
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| Scientists tested in the HaCaT epithelial cells, in vitro, the effect of subchronic treatments with sublethal doses of four different, well-characterized graphene-based materials, two commercial graphene oxides, and two few-layer graphenes.
[Nanotoxicology] |
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| The authors focus on four aspects involved in the pathogenesis of Diabetic foot ulcers: physiological and pathological mechanisms, cellular mechanisms, molecular signaling pathway mechanisms, and epigenetics.
[Journal Of Diabetes] |
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| The FDA has accepted a supplemental Biologics License Application (BLA) to treat Opdivo (nivolumab) in patients with stage 2B or 2C melanoma that has been completely resected, according to Bristol Myers Squibb, the manufacturer of the immunotherapy agent.
[Bristol Myers Squibb (Drug Topics)] |
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| March 19 – 23, 2023
Banff, Alberta, Canada |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | Stanford University School of Medicine – Stanford, California, United States |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Columbia University – New York, New York, United States |
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