 | | Vol. 9.09 – 20 March, 2023 |
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The authors reported that SIRT7 orchestrated melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein response.
[Signal Transduction And Targeted Therapy] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers presented a 3D innervated epidermal keratinocyte layer as a sensory neuron-epidermal keratinocyte co-culture model on a microfluidic chip using the slope-based air-liquid interfacing culture and spatial compartmentalization.
[Nature Communications] |
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| Scientists observed that the skin cells harvested from post-hair plucking day three had the best self-organizing ability during skin organoid culture and have the highest hair regeneration upon transplantation.
[Molecular Therapy – Nucleic Acids] |
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| CRISPR-generated KO keratinocytes had permanent suppression of IFN-κ and IFN-stimulated gene expression, secondary to hypermethylation of the IFNK promoter region by the DNA methyltransferase DNMT3B.
[European Journal Of Clinical Investigation] |
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| The full-length cDNA sequence of β-carotene oxygenase 2 (BOC2) from the rainbow trout was obtained, and qRT-PCR was used to investigate the differential expression of miR-330 and BCO2 in 14 developmental stages and 13 tissues between wild-type rainbow trout and yellow mutant rainbow trout.
[BMC Genomics] |
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| The authors questioned whether increases in telomerase components might mediate the acquisition of the tumorigenic phenotype. They therefore transduced the TERT and TERC genes into E6/E7 immortalized keratinocytes that were anchorage-dependent and non-tumorigenic.
[Journal Of Medical Virology] |
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| Researchers showed that, while at the primary epidermal stage, melanoma cells secreted extra cellular vesicles termed melanosomes, which were up taken by dermal lymphatic cells, leading to transcriptional and phenotypic pro-lymphangiogenic changes.
[Journal Of Investigative Dermatology] |
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| Hyperproliferation of keratinocytes, hyperkeratosis, inflammatory cell infiltration, and hypervascularity were histologically suppressed by topical imatinib mesylate. The expression of angiogenic factors including fibroblast growth factor and vascular endothelial growth factor was decreased.
[Experimental Dermatology] |
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| The role of suprabasin (SBSN) was investigated in oral squamous cell carcinoma (OSCC) under hypoxic conditions using the SAS, HSC‑3, and HSC‑4 cell lines. Hypoxia induced SBSN mRNA and protein expression in OSCC cells and normal human epidermal keratinocytes, and this was most prominent in SAS cells.
[Oncology Reports] |
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| The authors discuss the changes in the concepts of both the pathogenesis of and treatment approach to atopic dermatitis, highlight the scientific rationale behind each targeted treatment and report the most recent clinical efficacy data.
[Cellular & Molecular Immunology] |
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| In this systematic review of 54 studies reporting on 64 patients with acne, tumor necrosis factor–α inhibitors (TNFis) effectively treated acne in 47 patients and were associated with the development of acne in 17 patients being treated for another inflammatory condition, which often necessitated TNFi discontinuation.
[Jama Dermatology] |
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| Investigators recent studies on various decellularization processes as well as biological, physical, and mechanical properties of fish skin and its applications with therapeutic effects in wound healing were investigated.
[International Wound Journal] |
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| The kick-off meeting for the European ‘SkinDev’ project begins. The project aims to design treatments based on microbiomes with a synthetic biological component to detect and treat atopic dermatitis.
[Universitat Pompeu Fabra Barcelona] |
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| | Arcaea – Boston, Massachusetts, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Stanford University School of Medicine – Stanford, California, United States |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Columbia University – New York, New York, United States |
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