 | | Vol. 9.10 – 27 March, 2023 |
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| By examining the differentiation of the tactile bristles, mechanosensory organs decorating the Drosophila adult epidermis, researchers showed that neighbouring epidermal cells were essential for touch perception.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Scientists presented a highly accurate machine learning-based hair cell analysis toolbox for the comprehensive analysis of whole cochleae across light microscopy imaging modalities and species.
[PLOS Biology] |
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| The authors reported that through secreted soluble factors, Gram-positive anaerobic cocci rapidly and directly induced epidermal host-defense molecules in cultured human keratinocytes and indirectly via immune-cell activation and cytokines derived thereof.
[iScience] |
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| Given the mechanism of hair follicle morphogenesis being triggered by reciprocal interactions and the organization of the epithelial and mesenchymal cell populations, scientists developed an approach to induce hair peg-like sprouting in organoid cultures composed of epithelial and mesenchymal cells.
[Scientific Reports] |
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| Researchers evaluated the potential and specificity of the inflammatory and antioxidant response of Microbe‐Associated Molecular Patterns in NIH-3T3 fibroblast cells, as well as in the healing process of skin wounds.
[Archives Of Microbiology] |
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| The authors used multiomics analyses to reveal that NRAS-mutated melanoma cells adopt a mesenchymal phenotype with a quiescent metabolic program to resist cellular stress induced by MEK inhibition.
[Cancer Research] |
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| Investigators developed a novel cell-based method for large-scale screening of NRAS G4 ligand using the G-quadruplex-triggered fluorogenic hybridization probe and successfully identified the clinically used agent Octenidine as a potent NRAS repressor.
[Journal Of Medicinal Chemistry] |
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| Expression and protein analysis of normal skin and non-melanoma skin cancer samples showed the alteration of the expression of two enzymes involved in the serine metabolism and one-carbon metabolism.
[Cell Death Discovery] |
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| Extracellular matrix derived from GD2-expressing melanomas enhanced the malignant phenotypes of GD2-negative melanomas, such as cell growth, invasion, and cell adhesion, in a dose-dependent manner.
[Scientific Reports] |
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| A subcutaneous tumor model, and experimental metastasis models that simulated the outgrowth of melanoma cells in the brain, lung, and bone were established to verify the inhibitory effect of FPZ on melanoma cells.
[Clinical & Experimental Metastasis] |
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| Investigators explored the effects of maslinic acid on oxidative damage in human foreskin fibroblast cells and the potential molecular mechanisms.
[Journal Of Cosmetic Dermatology] |
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| Scientists review the structure and function of skin tissue and the process of wound healing, and summarize the materials and manufacturing methods used to fabricate skin tissue engineering scaffolds.
[Biomaterials Science] |
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| Because inflammation is a key driver of the signs and symptoms of stasis dermatitis (SD), several of the highlighted biomarkers of inflammation represent potential opportunities to target and interrupt molecular pathways of cutaneous inflammation and, therefore, remediate the signs and symptoms of SD.
[Dermatology And Therapy] |
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| Regulatory approval of Incyte’s cancer immunotherapy, Zynyz, comes two years after the FDA rejected an application seeking approval in a rare type of anal cancer.
[MedCityNews] |
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| Sixteen professors in the UM Rady Faculty of Health Sciences have been awarded a total of nearly $9 million in project grants from the Canadian Institutes of Health Research.
[Univrsity of Manitoba] |
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| | Firmenic – Los Angeles, California, United States |
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| | Arcaeay – Boston, Massachusetts, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Stanford University School of Medicine – Stanford, California, United States |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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