Dermal Cell News Volume 9.11 | Apr 3 2023

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    2023-04-03 | DCN 9.11


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.11 – 3 April, 2023
    TOP STORY

    Cytotoxic CD4+ T Cells Eliminate Senescent Cells by Targeting Cytomegalovirus Antigen

    Researchers demonstrated that a virus-immune axis controlled the senescent fibroblast accumulation in the human skin. Senescent fibroblasts increased in old skin compared with young skin.
    [Cell]

    AbstractPress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    Characterization and Anti-Aging Effects of Opuntia ficus-indica (L.) Miller Extracts in a D-Galactose-Induced Skin Aging Model

    The in vitro collagenase and elastase enzyme inhibitory effects of extracts from different parts of Opuntia ficus-indica (L.) Miller were evaluated.
    [Food & Function]

    AbstractGraphical Abstract

    Zebrafish Cutaneous Injury Models Reveal That Langerhans Cells Engulf Axonal Debris in Adult Epidermis

    Scientists established zebrafish scales as a tractable model to study axon degeneration in the adult epidermis. Using this system, they demonstrated that skin-resident immune cells known as Langerhans cells engulf the majority of axon debris.
    [Disease Models & Mechanisms]

    Full Article

    Nanoencapsulated Cordyceps Extract Enhances Collagen Synthesis and Skin Cell Regeneration through Antioxidation and Autophagy

    Investigators examined extracellular matrix, antioxidant effect, autophagy activity, and skin regeneration in human dermal fibroblasts under normal and oxidative stress conditions.
    [Journal Of Microencapsulation]

    Abstract

    Effect of Plantago asiatica L. Extract on the Anagen Phase in Human Hair Follicle Dermal Papilla Cells

    Researchers investigated the hair growth-stimulating activities of Plantago asiatica L. extract and its molecular mechanism in hair follicle dermal papilla cells.
    [Journal Of Cosmetic Dermatology]

    Full Article

    RNF31 Promotes Tumorigenesis via Inhibiting RIPK1 Kinase-Dependent Apoptosis

    The authors demonstrated a cancer cell-intrinsic role of linear ubiquitin chain assembly complex (LUBAC) complex in the tumor microenvironment to promote tumorigenesis.
    [Oncogene]

    Abstract

    Aspartate Beta-Hydroxylase Domain Containing 1 as a Prognostic Marker Associated with Immune Infiltration in Skin Cutaneous Melanoma

    The gene expression data of aspartate beta-hydroxylase domain containing 1 and differentially expressed genes from TCGA and GTEx were evaluated, and verified via the GEO database.
    [BMC Cancer]

    Full Article

    LC–MS Metabolomics Reveal Skin Metabolic Signature of Psoriasis Vulgaris

    Scientists performed liquid chromatography–mass spectrometry-based nontargeted metabolomic analysis to compare metabolic profile between lesional and nonlesional skin from 12 patients with psoriasis vulgaris.
    [Experimental Dermatology]

    Abstract

    LncRNA NEAT1 Antagonizes the Inhibition of Melanoma Proliferation, Migration, Invasion and EMT by Polyphyllin B

    The authors screened nuclear paraspeckle assembly transcript 1 (NEAT1) by using LncRNA transcriptomic sequencing, and then transfected B16F10 cells using OVER-NEAT1 lentivirus.
    [Naunyn-Schmiedebergs Archives Of Pharmacology]

    Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    REVIEWS

    Advanced In Vitro Three-Dimensional Skin Models of Atopic Dermatitis

    The authors introduce various types of in vitro skin models including 3D culture methods, skin-on-a-chips, and skin organoids, as well as their applications to atopic dermatitis modeling for drug screening and mechanistic studies.
    [Journal Of Tissue Engineering And Regenerative Medicine]

    Abstract

    Collagen Supplementation in Skin and Orthopedic Diseases: A Review of the Literature

    Scientists conduct a literature review on the scientific evidence regarding the beneficial effects of collagen consumption in the treatment of skin and orthopedic diseases.
    [Heliyon]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Finds at Least 19 Cases of Skin Cancer in Breast Implant Data, including 3 Deaths

    Though the FDA has long been aware of the risk that some people with breast implants may develop a rare form of T cell lymphoma—now known as breast implant-associated anaplastic large cell lymphoma and tracked by the regulator since 2011—the agency has only recently begun warning about other cancer risks linked to the implants.
    [Fierce Biotech]

    Press Release

    Cutiss Sends Skin Cells to the International Space Station

    Swiss bioengineering firm Cutiss launched skin cell experiments to the International Space Station on March 14 on SpaceX CRS-27, the same mission that ferried up heart-tissue-on-a-chip projects from Stanford and Johns Hopkins universities.
    [Cutiss (Fierce Biotech)]

    Press Release

    Mount Sinai Awarded Prestigious $1.3 Million Grant to Expand Research Training Program in Skin Biology

    The Kimberly and Eric J. Waldman Department of Dermatology at the Icahn School of Medicine at Mount Sinai will expand its research training program in skin biology with support from a five-year, $1.3 million T32 grant from the National Institutes of Health and the National Institute of Arthritis and Musculoskeletal and Skin Diseases.
    [Mount Sinai (NewsWise, Inc.)]

    Press Release
    FEATURED EVENT

    Meet the Models: Understand Disease Progression & Accelerate Therapeutic Development

    May 3 – 4, 2023
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Computational Biology & Spatial Omics

    Harvard Medical School – Boston, Massachusetts, United States

    Scientist – Skin Biology

    Firmenic – Los Angeles, California, United States

    Associate Scientist – Skin Biology

    Arcaeay – Boston, Massachusetts, United States

    Postdoctoral Research Fellow – Tumor-on-Chip Metastasis Model

    Oslo University Hospital – Oslo, Norway

    Research Assistant – Epithelial Biology and Dermatology

    Stanford University School of Medicine – Stanford, California, United States

    > See All Jobs

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