 | | Vol. 9.12 – 10 April, 2023 |
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| Investigators defined DNA methylation changes that accompany metastatic progression in melanoma patients and discovered Nuclear Receptor Subfamily 2 Group F, Member 2 – isoform 2 (NR2F2-Iso2) as an epigenetically regulated metastasis driver.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| To investigate transcriptional responses to pollutants in killer whale cells, investigators collected skin biopsies of killer whales from the Northern Norwegian fjords and successfully established primary fibroblast cell cultures from the dermis of four out of five of them.
[Environment International] |
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| The methacrylated fibrinogen hydrogels supported the growth and metabolic activity of human dermal fibroblasts in both 2D and 3D cultures.
[Acta Biomaterialia] |
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| Wound tissues were collected and analyzed to determine the impacts of Tongsaimai on collagen deposition, epithelial cell proliferation, oxidative stress, inflammation, and angiogenesis.
[Journal Of Ethnopharmacology] |
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| The authors investigated senescent fibroblasts in keloids and assessed the effects of dasatinib on these cells. Tissues acquired from keloid removal surgery were analyzed for senescence-associated β-galactosidase-positive cells, p16 expression, and the effects of dasatinib treatment on keloids.
[Acta Dermato-Venereologica] |
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| Single cell RNA sequencing of HPV16 infected compared to uninfected organoids identified 12 distinct keratinocyte populations, with a subset mapped to reconstruct their respective 3D geography in stratified squamous epithelium.
[Nature Communications] |
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| Scientists found that brusatol inhibited melanoma cell proliferation and migration and promoted cell apoptosis in vitro, in addition to suppressing melanoma cell tumorigenesis in vivo.
[Biomedicine & Pharmacotherapy] |
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| The authors explored the role of cellular senescence in the tumor microenironment of skin cutaneous melanoma through bioinformatics and machine learning.
[Computers In Biology And Medicine] |
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| Researchers developed a CRISPR-based gene editing approach, which they termed CRISPR-Clear, that was easily incorporated into existing tissue-clearing workflows, and they demonstrated its applicability to highly melanin-rich B16-derived solid tumors.
[Communications Biology] |
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| The authors compare and contrast the intricate mechanisms and elements of homeostasis and injury-driven regeneration in the epidermis, hematopoietic system, and intestinal epithelium—the fastest renewing tissues in mammals.
[Cell Stem Cell] |
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| Scientists review the antitumor potential of interleukin-1 (IL-1) receptor antagonist as an IL-1-targeted inhibitor, in the context of human squamous cell carcinomas.
[Heliyon] |
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| The placebo-controlled, randomised Phase III trial was designed for assessing Merck’s anti-PD-1 therapy Keytruda and Eisai’s Lenvima against Keytruda alone for the first-line treatment of adult patients.
[Clinical Trials Arena (Merck Inc)] |
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April 24, 2023
Chicago, Illinois, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Firmenic – Los Angeles, California, United States |
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| | Arcaeay – Boston, Massachusetts, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Stanford University School of Medicine – Stanford, California, United States |
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