Dermal Cell News Volume 9.13 | Apr 17 2023

    By
    Laurisa Dohm
    -
    0
    83








    2023-04-17 | DCN 9.13


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.13 – 17 April, 2023
    TOP STORY

    Localized Immune Surveillance of Primary Melanoma in the Skin Deciphered through Executable Modeling

    The authors developed an in silico model to determine the local cross-talk between melanomas and Langerhans cells, the primary antigen-presenting cells at the site of melanoma development.
    [Science Advances]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    Melatonin Improves Skin Barrier Damage Caused by Sleep Restriction through Gut Microbiota

    Researchers verified in vitro that propionic acid could improve the keratinocytes barrier function of oxidative damage, and then consumed the gut microbiota of mice through antibiotics and found that oral melatonin could not improve skin damage.
    [Journal Of Pineal Research]

    Abstract

    Contact Guidance of Connective Tissue Fibroblasts on Submicrometer Anisotropic Topographical Cues Is Dependent on Tissue of Origin, β1 Integrins, and Tensin-1 Recruitment

    Utilizing repeating groove substrates with periodicities of 600, 900, and 1200 nm, and a 100 nm depth, the authors investigated the roles of integrins αvβ3 and β1 associated adhesions on contact guidance of human gingival and dermal fibroblasts.
    [ACS Applied Materials & Interfaces]

    Full Article

    Enhanced Wound-Healing Efficacy of Electrospun Mesoporous Hydroxyapatite Nanoparticle-Loaded Chitosan Nanofiber Developed Using Pluronic F127

    Alongside the evaluation of cytocompatibility through in vitro cell viability assay, the wound healing efficacy was also determined in full-thickness skin wounds in a rat model for 15 days.
    [International Journal of Biological Macromolecules]

    Full ArticleGraphical Abstract

    ceAF Ameliorates Diabetic Wound Healing by Alleviating Inflammation and Oxidative Stress via TLR4/NF-κB and Nrf2 Pathways

    Chick early amniotic fluids (ceAF) increased M2 macrophage-specific markers expression and exogenous ceAF suppressed LPS-induced cellular inflammatory response in vitro high glucose environment.
    [Journal Of Diabetes Research]

    Full Article

    Localized Immune Surveillance of Primary Melanoma in the Skin Deciphered through Executable Modeling

    Scientists developed an in silico model to determine the local cross-talk between melanomas and Langerhans cells, the primary antigen-presenting cells at the site of melanoma development.
    [Science Advances]

    Full Article

    TFCP2 Is a Transcriptional Regulator of Heparan Sulfate Assembly and Melanoma Cell Growth

    To investigate the role of TFCP2 in heparan sulfate (HS) assembly, scientists targeted TFCP2 expression in human melanoma cells using the CRISPR/Cas9 system.
    [Journal Of Biological Chemistry]

    Full Article

    Evaluation of the Effect of Fibroblasts on Melanoma Metastasis Using a Biomimetic Co-Culture Model

    Gelatin methacryloyl (GelMA) was used to construct a co-culture model for melanoma cells, A375, and fibroblasts. Fibroblasts were encapsulated in GelMA, whereas A375 cells were cultured on the GelMA surface, which realistically mimicked the macrostructure of melanoma.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Prosopis juliflora (Sw.) DC Phytochemicals Induce Apoptosis and Inhibit Cell Proliferation Signaling Pathways, EMT, Migration, Invasion, Angiogenesis and Stem Cell Markers in Melanoma Cell Lines

    Treatment of B16F10 melanoma cells with Prosopis Juliflora leaves methanol extract PJLME resulted in arrest of cell cycle at G0/G1 phase. Annexin V-FITC/PI assay confirmed the apoptosis inducing potential of PJLME in B16F10 and A375 melanoma cells.
    [Journal Of Ethnopharmacology]

    Full ArticleGraphical Abstract

    Synthesis, Molecular Docking, and Biological Evaluation of [3,2-B]indole Fused 18β-Glycyrrhetinic Acid Derivatives against Skin Melanoma

    Investigators described the synthesis and selective anti melanoma activity of indole fused 18β-glycyrrhetinic acid, a derivative of 18β-glycyrrhetinic acid, in murine B16F10 and A375 human melanoma cell lines.
    [Rsc Advances]

    Full Article
    Submit your best cell image to the #StemCellfie contest!
    REVIEWS

    Direct Lineage Reprogramming for Induced Keratinocyte Stem Cells: A Potential Approach for Skin Repair

    The authors focus on lineage transcription factor-mediated direct reprogramming, describing the conversion process and underlying epigenetic mechanisms, and other potential induction strategies to generate induced keratinocyte stem cells, and challenges associated with in situ reprogramming for skin repair.
    [Stem Cells Translational Medicine]

    Full ArticleGraphical Abstract

    Skin Aging from the Perspective of Dermal Fibroblasts: The Interplay between the Adaptation to the Extracellular Matrix Microenvironment and Cell Autonomous Processes

    Scientists review how dermal aging involves a feed‐forward process that reinforces the aged dermal fibroblast phenotype and promotes age‐related dermal extracellular matrix deterioration, and discuss the expression of the aged dermal fibroblast phenotype.
    [Journal Of Cell Communication And Signaling]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Moderna and Merck Announce mRNA-4157, an Investigational Individualized Neoantigen Therapy, in Combination with KEYTRUDA®, Demonstrated Superior Recurrence-Free Survival in Patients with High-Risk Stage III/IV Melanoma following Complete Resection versus KEYTRUDA

    In the overall intention-to-treat population, adjuvant treatment with mRNA-4157 in combination with KEYTRUDA demonstrated a statistically significant and clinically meaningful improvement in recurrence-free survival compared with KEYTRUDA alone.
    [Merck]

    Press Release
    FEATURED EVENT

    The Resistant Tumor Microenvironment

    May 7 – 10, 2023
    Vancouver, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Cancer Research

    Case Western Reserve University – Cleveland, Ohio, United States

    Postdoctoral Research Associate – Head and Neck Cancer

    University of Liverpool – Liverpool, England, United Kingdom

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Fellowship – Computational Biology & Spatial Omics

    Harvard Medical School – Boston, Massachusetts, United States

    Scientist – Skin Biology

    Firmenic – Los Angeles, California, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter