Dermal Cell News Volume 9.14 | Apr 24 2023

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    2023-04-24 | DCN 9.14


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.14 – 24 April, 2023
    TOP STORY

    Design and Characterization of Adipose-Derived Mesenchymal Stem Cell Loaded Alginate/Pullulan/Hyaluronic Acid Hydrogel Scaffold for Wound Healing Applications

    In in vitro studies, cells could be attached, alive, and migrate through the prepared hydrogel scaffold. The therapeutic effect of the cell-seeded hydrogels was tested in the full-thickness animal wound model.
    [International Journal of Biological Macromolecules]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Design, Optimization and Characterization of a Novel Antibacterial Chitosan-Based Hydrogel Dressing for Promoting Blood Coagulation and Full-Thickness Wound Healing: A Biochemical and Biophysical Study

    Cell studies showed biocompatibility and non-toxicity of the hydrogel along with the promotion of cell migration, and the in vivo data revealed enhanced tissue regeneration and recovery within 17 days in the studied animals.
    [International Journal of Biological Macromolecules]

    Abstract

    A Chronic Wound Model to Investigate Skin Cellular Senescence

    The authors described a chronic wound murine model and its cellular senescence profile, including the senescence-associated secretory phenotype.
    [Aging-Us]

    Full Article

    Neuropeptide Y Promotes the Treatment of Adipose Stem Cells on Type 2 Diabetic Wounds

    Scientists investigated the effects of neuropeptide Y (NPY) on adipose-derived stem cells (ASCs) proliferation and growth factors expression and secretion, the effects of NPY on skin fibroblasts, and the effects of NPY combined with ASCs on Type 2 diabetes wound healing.
    [Tissue Engineering And Regenerative Medicine]

    Abstract

    Mechanistic Synergy of Hair Growth Promotion by the Avicennia marina Extract and Its Active Constituent (Avicequinone C) in Dermal Papilla Cells Isolated from Androgenic Alopecia Patients

    Researchers used human dermal papilla cells isolated from androgenic alopecia (AGA) patients’ hair that expressed 5α-R type-1 as well as the androgenic receptor at high levels to explore the potential use of the Avicennia marinaextract and of avicequinone C as anti-AGA agents.
    [PLOS One]

    Full Article

    Common Fragrance Chemicals Activate Dendritic Cells in Coculture with Keratinocytes

    To evaluate the 2D coculture model consisting of keratinocytes and dendritic cells, different weak to moderate sensitizing fragrance chemicals were tested in the coculture activation test, consisting of HaCaT keratinocytes and THP-1 cells.
    [Contact Dermatitis]

    Full Article

    BORIS/CTCFL-Mediated Chromatin Accessibility Alterations Promote a Pro-Invasive Transcriptional Signature in Melanoma Cells

    ATAC-seq was used to study brother of regulator of imprinted sites (BORIS)-mediated chromatin accessibility alterations in melanoma cells harboring an intermediate melanocytic state.
    [Pigment Cell & Melanoma Research]

    Full Article

    Exosomes from Adipose-Derived Stem Cells Inhibits Skin Cancer Progression via miR-199a-5p/SOX4

    The impact of miR-199a-5p produced by adipose-derived stem cells on malignant melanoma skin cancer was investigated in 30 pair tumor tissues and adjacent tissues obtained from skin cancer patients.
    [Biotechnology and Genetic Engineering Reviews]

    Abstract

    MicroRNA-708 Emerges as a Potential Candidate to Target Undruggable NRAS

    Overexpression of miRNA-708 successfully reduced NRAS protein levels in melanoma, leukemia, and lung cancer cell lines with NRAS mutations, resulting in suppressed cell proliferation, anchorage-independent growth, and promotion of reactive oxygen species-induced apoptosis.
    [PLOS One]

    Full Article
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    REVIEWS

    Clinical and Molecular Overview of Immunotherapeutic Approaches for Malignant Skin Melanoma: Past, Present and Future

    Scientists discuss the current immunotherapeutic regimens used to treat malignant melanoma, the molecular and cellular mechanisms involved, and current clinical studies that have investigated the use, efficacy, and adverse events of immunotherapy in melanoma.
    [Critical Reviews In Oncology/Hematology]

    Full ArticleGraphical Abstract

    Advances in Mesenchymal Stem/Stromal Cell-Based Therapy and Their Extracellular Vesicles for Skin Wound Healing

    The authors highlight recent studies that investigated therapeutic potential of various mesenchymal stem/stromal cells (MESCs) and MSC-extracellular vesicles in skin damages and wounds.
    [Human Cell]

    Abstract
    INDUSTRY AND POLICY NEWS

    Incyte Announces European Commission Approval of Opzelura® (Ruxolitinib) Cream for the Treatment of Non-Segmental Vitiligo with Facial Involvement in Adults and Adolescents

    Incyte announced that the European Commission has granted a marketing authorization for Opzelura® (ruxolitinib) cream 15mg/g for the treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age.
    [Incyte]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Biology

    University of Gothenburg – Gothenburg, Sweden

    Faculty Positions – Cancer Research

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    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

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    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Researcher – Immune Competent Tumor-on-Chip Model

    Oslo University Hospital – Oslo, Norway

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