|
| The authors showed that, in contrast to most pathogen-induced cytokines, interleukin-24 was predominately induced by barrier epithelial progenitors after tissue injury and was independent of microbiome or adaptive immunity.
[Cell] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
|
|
|
| By single-cell RNAseq, investigators showed that MYC/NICD “rejuvenated” the adult mouse cochlea by activating multiple pathways including Wnt and cyclase activator of cyclic AMP, whose blockade suppressed cochlear hair cell-like cell regeneration despite Myc/Notch activation.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
|
|
|
| Researchers demonstrated that G2 cells were required to initiate normal levels of Ca2+ signaling, while connexin43 connected basal cells to orchestrate tissue-wide coordination of Ca2+ signaling.
[Journal Of Cell Biology] |
|
|
|
| The expression of nuclear receptor coactivator 4 (NCOA4), a key factor that influenced ferritinophagy, was decreased in both diabetic wound tissue and high glucose-induced senescent fibroblasts.
[Cell Death Discovery] |
|
|
|
| XTT and LDH tests on fibroblasts and keratinocytes were performed to assess the cytotoxicity of the RADA16-I hybrids, while the viability of cells treated with RADA16-I hybrids was evaluated in a model of human dermal fibroblasts.
[Scientific Reports] |
| |
|
|
| Scientists showed that most melanocyte stem cells toggled between transit-amplifying and stem cell states for both self-renewal and generation of mature progeny, a mechanism fundamentally distinct from those of other self-renewing systems.
[Nature] |
|
|
|
| Investigators focused on Slc46a2, which was highly expressed in mammalian epidermal keratinocytes, and showed that it was critical for the delivery of diaminopimelic acid-muropeptides and activation of NOD1 in keratinocytes.
[Immunity] |
|
|
|
| Mechanistically, macrophages mediated psoriasis via the Mincle-Syk-NF-κB pathway, as blocking macrophage Mincle inhibited Syk/NF-κB-driven skin lesions and epidermal injury in vivo and in vitro.
[Cell Death Discovery] |
|
|
|
| Researchers found that heat stress promoted melanogenesis in pigment cells by increasing the paracrine effects of keratinocytes, and high-throughput RNA sequencing showed that heat stress activated the Hedgehog (Hh) signaling pathway in keratinocytes.
[iScience] |
|
|
|
|
| Scientists describe a new understanding of melanocyte biology and the different melanocyte subpopulations and microenvironments they inhabit, and how this provides unique insights into melanoma initiation and progression.
[Nature Reviews Cancer] |
|
|
|
| The authors summarize small interfering RNA (siRNA)-based nanotherapeutics for treating skin disorders, inlcuding the mechanisms involved, the different nanoparticle types used for siRNA skin delivery, and how nanoparticles enhance siRNA skin penetration.
[Expert Opinion On Drug Delivery] |
|
|
|
|
| The nine-year wait for new clinical data on Promore Pharma’s ensereptide has ended in disaster, with the failure of the polypeptide to reduce scarring in a midphase trial wounding the biotech’s share price.
[Fierce Biotech] |
|
|
|
|
| May 28 – 31, 2023
Killarney, Ireland |
|
|
|
|
|
| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
|
|
|
| | University of Gothenburg – Gothenburg, Sweden |
|
|
|
| | Case Western Reserve University – Cleveland, Ohio, United States |
|
|
|
| | Harvard Medical School – Boston, Massachusetts, United States |
|
|
|
| | Firmenic – Los Angeles, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
