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| The effects of a CXCR1/CXCR2 antagonist, SX-682, on melanoma tumorigenesis were evaluated in BrafV600E/Pten−/− and NRasQ61R/INK4a−/− mice and in melanoma cell lines.
[Molecular Cancer] |
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|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers captured transcriptional states of single cells over space and time during skin wound closure, revealing choreographed gene-expression profiles.
[Cell Stem Cell] |
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| Mechanistically, retinoic acid inducible-gene I (RIG-I) promoted keratinocyte proliferation and wound repair by inducing TIMP-1 via the NF-κB signaling pathway.
[Journal Of Cellular Physiology] |
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| Viabilities of full-thick skin samples cultured on the microbioreactor and traditional tissue culture plate revealed that a precise controlled condition provided by the microfluidic enhanced tissue viability at least for seven days.
[Scientific Reports] |
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| The novel fibers exhibited a reproducible fiber diameter range and morphology, while the mechanical fiber properties were ideal for application onto wounds. Immediate release kinetics for the phages were confirmed as well as the biocompatibility of the fibers with human skin cells.
[Scientific Reports] |
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| Single-cell RNA-sequencing of tumors showed a concordance between genes regulating pigmentation and those involved in lipid and oxidative metabolism. This state was conserved across human melanoma cell lines and patient tumors.
[Nature Communications] |
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| Single-cell analysis revealed that only a small subset of melanoma cells exhibited effective receptor tyrosine kinase (RTK) and ERK activation and developed persisters, despite uniform external stimuli.
[Cell Reports] |
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| Investigators explored the mechanism of action of a highly specific PI3K/mTOR inhibitor, and Mnk inhibitor, alone and in combination, as well as their effect on the viability and invasiveness of melanoma cells.
[Cellular Signalling] |
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| Epidermal high-mobility group box 1 (HMGB1) release from antitumor necrosis factor-alpha (TNF-α) treated, or doxycycline-inducible RIPK3 or Bak-expressing human keratinocyte cells was determined by western blot/ELISA.
[Journal Of Dermatology] |
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| Neuroimmune crosstalk in the skin, through interactions of primary sensory neurons with the immune system, has been shown to regulate host cutaneous defense, inflammation, and tissue repair. Scientists review current knowledge about the cellular and molecular mechanisms involved in this crosstalk.
[Trends In Neurosciences] |
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| The authors review the research progress on the mechanism of targeted therapies for pemphigus.
[Heliyon] |
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| The Council has adopted conclusions on the ‘high quality, transparent, open, trustworthy and equitable scholarly publishing’, in which it calls for immediate and unrestricted open access in publishing research involving public funds.
[Council of the European Union] |
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| July 7 – 8, 2023
Montréal, Québec, Canada |
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| | Malmö University – Malmö, Sweden |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Institut Pasteur – Paris, France |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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