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| Using genetic lineage tracing and live imaging in explants and in wounded animals, the authors observed that injury induced a transient migratory state in adipocytes with vastly distinct cell migration patterns and behaviors from fibroblasts.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Mechanistically, ILEI triggered Erk and Akt signaling, which then activated STAT3 via Ser727 phosphorylation. Keratinocyte-specific ILEI deletion ameliorated TPA-induced skin inflammation.
[EMBO Molecular Medicine] |
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| Researchers reported two different methods for generating melanoma patient-derived organoids, one which was embedded in collagen gel, and the other which was inlaid in Matrigel.
[Ebiomedicine] |
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| By combining differential gene expression, pseudotime analyses, and spatial localization, scientists reconstructed human-skin-equivalent organoid cultures keratinocyte differentiation trajectories that recapitulated known in vivo epidermal differentiation pathways.
[Cell Reports] |
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| The anti-inflammatory and antioxidant activity of undifferentiated callus extracts from Plantago major L, Rhodiola rosea L, and Silybum marianum L was investigated both in normal and malignant skin cells.
[Heliyon] |
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| | The authors showed that hair follicle stem cells in the bulge were stiff with high actomyosin contractility and resistance to size change, whereas hair germ progenitors were soft and periodically enlarged and contracted during quiescence
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators used healthy, organ-cultured human scalp hair follicles to interrogate the role of mTORC1 in a prototypic human (mini-)organ.
[EMBO Reports] |
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| Researchers explored the functionality of the matrix-bound CCN1 by culturing dermal fibroblasts on an acellular matrix plate that was enriched with a high concentration of CCN1.
[Journal Of Cell Communication And Signaling] |
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| Scientists validated that silencing the expression of RAC1 could restrain the proliferation and migration, promote apoptosis, as well as increase the expression of PD-1/PD-L1 and CTLA4 in melanoma cells.
[Scientific Reports] |
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| The authors summarize advances in the development of novel drug, biologic products, and biomaterial therapies for wound healing for marketed therapies and those in clinical trials.
[Science Advances] |
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| Scientists provide evidence of the role of TGF-β and fibroblast growth factor (FGF) signaling pathways in the development of different skin layers, especially the disparate dermis of different body regions.
[Cell Proliferation] |
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| The authors focus on the role of chemokines in melanoma and possible therapeutic strategies to alter chemokine activation and subsequently inhibit the activation of signaling cascades that may promote metastasis.
[Cancer Medicine] |
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| Iovance Biotherapeutics, Inc. announced that the US FDA accepted its Biologics License Application for lifileucel for patients with advanced melanoma.
[Iovance Biotherapeutics, Inc.] |
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| June 18 – 22, 2023
Keystone, Colorado, United States |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Institut Pasteur – Paris, France |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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