 | | Vol. 9.20 – 12 June, 2023 |
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| Expression of CD40 by melanoma cells was associated with therapeutic response to RAF/MEK inhibition and immune checkpoint blockade.
[Molecular Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| A core-shell structured microneedle array patch with programmed functions was designed to dynamically modulate the wound immune microenvironment according to the varied healing phases.
[Nature Communications] |
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| Researchers demonstrated the robustness of human pluripotent stem cell-derived inner ear organoids and evaluated cell type heterogeneity by single-cell transcriptomics.
[Cell Reports] |
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| In vitro, recombinant microfibril-associated protein 5 significantly enhanced dermal fibroblast migration, collagen contractility, and expression of pro-fibrotic genes.
[Scientific Reports] |
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| Results revealed preservation and prominent proliferation of basal keratinocytes of the skin explants in addition to preservation of dermal collagen and vasculature at day six in the 3D-SeboSkin culture model, and to a lesser extent in co-culture with fibroblasts, but not in serum-free medium alone.
[Experimental Dermatology] |
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| Mechanistically, aberrant interleukin (IL)-17 signalled through NF-κB in epidermal cells to impair homeostatic functions while promoting an inflammatory state.
[Nature Aging] |
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| The peptide/polyvinyl alcohol double-network hydrogels were found to have good anti-cancer efficacy and target mouse melanoma cells B16-F10 while being nontoxic to normal cells.
[ACS Applied Materials & Interfaces] |
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| SLC35E1 deficiency inhibited keratinocyte proliferation in both mice and cultured cells. On a molecular level, SLC35E1 was found to regulate zinc ion concentrations and subcellular localization, while zinc ion chelation reversed the imiquimod-induced psoriatic phenotype in Slc35e1−/− mice.
[Cell Death & Disease] |
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| Scientists found that MTAP-ANRIL gene fusion downregulated the expression of wild-type MTAP and promoted epithelial-mesenchymal transition-like process through the activation of JNK and p38 MAPKs in vitro and in vivo.
[Scientific Reports] |
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| The authors dicsuss how the genetic mechanisms that drive cutaneous squamous cell carcinoma interact with the tumour microenvironment as it relates to efforts to prevent and treat the disease.
[Nature Reviews Cancer] |
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| Scientists focus on the recent literature concerning the transcriptional regulation of T helper cells in psoriasis.
[European Journal Of Medical Research] |
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| The month’s top grants in regenerative medicine, sourced from Dimensions, include projects on: high-resolution lineage tracing of developmental hematopoiesis, ROS signaling in wound healing versus tissue repair, and microglia engineering and replacement to treat brain disease.
[RedMedNet] |
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| June 26 – 30, 2023
Split, Croatia |
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| | Sorbonne-Universite – Paris, France |
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| | BioMed X – Ridgefield, Connecticut, United States |
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| | Malm̦ University РMalm̦, Sweden |
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| | Institut Pasteur – Paris, France |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
