Dermal Cell News Volume 9.21 | Jun 19 2023

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    Laurisa Dohm
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    2023-06-19 | DCN 9.21


    Dermal Cell News by STEMCELL Technologies
    Vol. 9.21 – 19 June, 2023
    TOP STORY

    A Rapid Self-Pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing

    Researchers reported a self-pumping organohydrogel dressing with hydrophilic fractal microchannels that could rapidly drain excessive exudates with about 30 times enhancement in efficiency compared with the pure hydrogel, and effectively promoted burn wound healing.
    [Advanced Materials]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Transcriptomic Landscape of Early Hair Follicle and Epidermal Development

    The authors used bulk and single-cell transcriptomics and pseudotime modeling to address questions in developing hair follicles and epidermis, and produced a comprehensive transcriptomic profile of cellular populations in the hair placode and interplacodal epithelium.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Dynamic Interplay between IL-1 and WNT Pathways in Regulating Dermal Adipocyte Lineage Cells during Skin Development and Wound Regeneration

    Using single-cell RNA sequencing of developing or wounded mouse skin, investigators classified dermal fibroblasts into distinct non-adipogenic and adipogenic cell states.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Yunnan Baiyao-Loaded Multifunctional Microneedle Patches for Rapid Hemostasis and Cutaneous Wound Healing

    Scientists found that when applied in rat cutaneous wounds, the proposed microneedles could accelerate the wound healing process by enhancing neovascularization, fibroblast density, and collagen deposition.
    [Journal Of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Deinococcus radiodurans-Derived Membrane Vesicles Protect HaCaT Cells against H2O2-Induced Oxidative Stress via Modulation of MAPK and Nrf2/ARE Pathways

    Pretreatment with membrane vesicles derived from D. radiodurans inhibited H2O2-mediated apoptosis in HaCaT cells by suppressing the loss of mitochondrial membrane potential and reactive oxygen species production.
    [Biological Procedures Online]

    Full Article

    Vitamin D Receptor Cross-Talk with p63 Signaling Promotes Epidermal Cell Fate

    Researchers deleted the vitamin D receptor gene, Vdr, from Lrig1 expressing stem cells in the isthmus of the hair follicle, then used lineage tracing to evaluate the impact on re-epithelialization following injury.
    [Journal Of Steroid Biochemistry And Molecular Biology]

    Abstract

    Single Cell and Spatial Sequencing Define Processes by Which Keratinocytes and Fibroblasts Amplify Inflammatory Responses in Psoriasis

    The authors demonstrated, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A and TNF inflammatory responses in the absence of neutrophil proteases, which primarily occur within the supraspinous layer of the psoriatic epidermis.
    [Nature Communications]

    Full Article

    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression

    Scientists showed that human germline lipid transporter apolipoprotein E (APOE) genetic variants differentially modulated melanoma growth and metastasis in an APOE2>APOE3>APOE4 manner.
    [Cancer Research]

    Abstract

    Double-Layered PLGA/HA Microneedle Systems as a Long-Acting Formulation of Polyphenols for Effective and Long-Term Management of Atopic Dermatitis

    Researchers reported a double-layered poly(lactic-co-glycolic acid) (PLGA)/sodium hyaluronate (HA) microneedle patch as a long-acting formulation for sustained delivery of natural polyphenols, curcumin and gallic acid, into the inflamed skin.
    [Biomaterials Science]

    Abstract
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Type VII Collagen Deficiency in the Oncogenesis of Cutaneous Squamous Cell Carcinoma in Dystrophic Epidermolysis Bullosa

    Scientists examine cutaneous squamous cell carcinoma (cSCC) pathophysiology in dystrophic epidermolysis bullosa, with a focus on known oncogenesis pathways at play, and explore the idea that therapeutic type VII collagen replacement may reduce cSCC risk.
    [Journal Of Investigative Dermatology]

    Full Article

    Heavy Metals in Contact Dermatitis: A Review

    The authors present an update on the epidemiological and clinical characteristics of allergic contact dermatitis and systemic contact dermatitis caused by three heavy metals, chromium, lead, and copper.
    [Journal Of Trace Elements In Medicine And Biology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Mozart Therapeutics Raises $25 Million in Expanded Series A Financing to Support Clinical Development of First-in-Class CD8 Treg Modulators for the Treatment of Autoimmune Diseases

    Mozart is developing a portfolio of CD8 Treg Modulators including MTX-101, a bispecifc autoimmune checkpoint inhibitor, for the treatment of autoimmune diseases. The company anticipates filing an investigational new drug and initiating a Phase I clinical trial for MTX-101 in early 2024.
    [Mozart Therapeutics]

    Press Release
    FEATURED EVENT

    2023 Biomaterials and Tissue Engineering

    July 16 – 21, 2023
    Holderness, New Hampshire, United States

    > See All Events

    JOB OPPORTUNITIES

    Director – Field Medical for GI/Skin/Lung Oncology

    Pfizer, Inc. – Southern California, United States

    Group Leader – Fibrosis and Wound Healing

    BioMed X – Ridgefield, Connecticut, United States

    Postdoctoral Position – Skin-Like Polymer Materials

    Sorbonne-Universite – Paris, France

    Postdoctoral Researchers – Molecular & Biophysical Aspects of Skin and Mucosa Barriers

    Malmö University – Malmö, Sweden

    Postdoctoral Position – Cellular Topography Sensing

    Institut Pasteur – Paris, France

    > See All Jobs

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