 | | Vol. 9.22 – 26 June, 2023 |
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| Using genetic mouse models of nevi, the authors showed that dermal clusters of senescent melanocytes drove epithelial hair stem cells to exit quiescence and change their transcriptome and composition, potently enhancing hair renewal.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Mechanistically, investigators showed that, unlike HrasG12V/+ cells, wild-type cells responded to autocrine and paracrine secretion of EGFR ligands, and this differential activation of the EGFR pathway explained the competitive switch during injury repair.
[Nature] |
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| Upon induction of differentiation, ∆Np63 down-regulation was associated by a marked increase of NEAT1 RNA levels, resulting in an increased assembly of paraspeckles foci both in vitro and in human skin tissues.
[Nature Communications] |
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| Findings demonstrated that the bilayer cell patch combining epidermal stem cells and angiogenic-modified adipose-derived stem cells transplantation could promote diabetic wound healing through enhancing angiogenesis and re-epithelization.
[Journal Of Controlled Release] |
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| Scientists found that the dimeric antimicrobial peptide Feleucin-K3 (Flc) and a collagen hybridizing peptide conjugate design preserved the potent and broad-spectrum antimicrobial activities of Flc, while significantly enhancing and extending its antimicrobial efficacy in vivo and facilitating tissue repair in a rat wound healing model.
[Journal Of Controlled Release] |
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| Researchers reported that progranulin overexpression decreased the expression of profibrotic genes alpha-smooth muscle actin, serum response factor, and connective tissue growth factor, thereby inhibiting skin fibrosis during wound repair.
[Cellular Signalling] |
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| Scientists employed single-cell RNA sequencing to examine the heterogeneity of keratinocytes and dermal fibroblast clusters in cctinic keratosis and adjacent normal skins.
[Journal Of The European Academy Of Dermatology And Venereology] |
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| Cellular assays verified that homeodomain-only protein homeobox (HOPX) inhibited the proliferation, migration, and invasion of A375 cells, and promoted apoptosis and S-phase arrest. Tumor drug sensitivity analysis revealed that HOPX also played an important role in reducing clinical drug resistance.
[Cancer Cell International] |
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| Cell viability, proliferation, and migration decreased with increasing GP-2250 doses. Flow cytometry revealed a dose response to GP-2250 in all three Merkel cell carcinoma cell lines.
[Journal Of Cancer Research And Clinical Oncology] |
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| The authors summarize the alterations in skin microbiota associated with acne, provide insight into its pathogenic role in acne, and emphasize the potential of therapeutic interventions aimed at restoring microbial homeostasis for acne management.
[Cell & Bioscience] |
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| Zenyaku Kogyo is lining up a challenge to Sanofi and Regeneron’s blockbuster Dupixent in Japan, paying Aslan Pharmaceuticals $12 million upfront for local rights to a midphase eczema drug candidate.
[Fierce Biotech] |
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| July 30 – August 4, 2023
Newport, Rhode Island, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | University College Dublin – Dublin, Leinster, Ireland |
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| | Pfizer, Inc. – Southern California, United States |
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| | BioMed X – Ridgefield, Connecticut, United States |
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| | Sorbonne-Universite – Paris, France |
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